Smad4 Deficiency in S100A4 + Macrophages Enhances Colitis-associated Tumorigenesis by Promoting Macrophage Lipid Metabolism Augmented M2 Polarization

S100A4 is primarily expressed in intestinal macrophages, and promotes colonic inflammation and colitis-associated colon tumorigenesis. Smad4 is also expressed in the colon; however, it inhibits colitis-associated cancer (CAC) development. The specific role of Smad4 in S100A4 cells in CAC remains unk...

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Veröffentlicht in:	International journal of biological sciences 2024-01, Vol.20 (15), p.6114-6129
Hauptverfasser:	Liu, Ting, Zhang, Xinyuan, Yan, Xuanxuan, Cheng, Leirong, Yan, Xinlong, Zeng, Fanxin, Li, Xue, Chen, Zhinan, Gu, Jianchun, Zhang, Jinhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Azoxymethane Carcinogenesis - metabolism Colitis - chemically induced Colitis - complications Colitis - metabolism Colitis-Associated Neoplasms - etiology Colitis-Associated Neoplasms - metabolism Colitis-Associated Neoplasms - pathology Dextran Sulfate Humans Lipid Metabolism Macrophages - metabolism Male Mice Mice, Inbred C57BL Research Paper S100 Calcium-Binding Protein A4 - genetics S100 Calcium-Binding Protein A4 - metabolism Smad4 Protein - genetics Smad4 Protein - metabolism
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