The Association of Prenatal Alcohol Exposure With Brain Development During the First 1000 Days of Life: A Systematic Review
ABSTRACT Prenatal exposure to alcohol (PAE) can impact short‐ and long‐term offspring health. However, knowledge on PAE and brain development in early life is limited. This systematic review investigated associations between PAE and brain development during the first 1000 days of life, and was regis...
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| Veröffentlicht in: | Prenatal diagnosis 2024-12, Vol.44 (13), p.1603-1613 |
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| creator | Pielage, Marin Rousian, Melek Heteren, Sem Groenenberg, Irene A. L. Hillegers, Manon H. J. Steegers, Eric A. P. Marroun, Hanan El |
| description | ABSTRACT
Prenatal exposure to alcohol (PAE) can impact short‐ and long‐term offspring health. However, knowledge on PAE and brain development in early life is limited. This systematic review investigated associations between PAE and brain development during the first 1000 days of life, and was registered in PROSPERO at CRD42022355144. The literature search was performed from inception until February 2024 in EMBASE, MEDLINE, Web of Science, PsycINFO, and the Cochrane Library. Studies investigating PAE and brain development during the first 1000 days using ultrasound, magnetic resonance imaging (MRI) or diffusion tensor imaging (DTI) were included. Our search initially identified 3618 articles, of which 16 were included. The findings suggest inconsistent associations between PAE and early brain development. Ultrasound studies on PAE and brain size report no clear relationship. Some postnatal MRI studies reported smaller thalami, amygdalae and hippocampi in alcohol exposed neonates. Postnatal DTI studies (n = 5) examining network integrity and connectivity reported bidirectional results in multiple brain networks. Our results highlight the need for further research on first trimester brain development, timing and quantity of alcohol exposure using a core set of validated instruments. Longitudinal assessments and standardized procedures for neuroimaging are crucial to understand the impact of PAE on early brain development. |
| doi_str_mv | 10.1002/pd.6694 |
| format | Article |
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Prenatal exposure to alcohol (PAE) can impact short‐ and long‐term offspring health. However, knowledge on PAE and brain development in early life is limited. This systematic review investigated associations between PAE and brain development during the first 1000 days of life, and was registered in PROSPERO at CRD42022355144. The literature search was performed from inception until February 2024 in EMBASE, MEDLINE, Web of Science, PsycINFO, and the Cochrane Library. Studies investigating PAE and brain development during the first 1000 days using ultrasound, magnetic resonance imaging (MRI) or diffusion tensor imaging (DTI) were included. Our search initially identified 3618 articles, of which 16 were included. The findings suggest inconsistent associations between PAE and early brain development. Ultrasound studies on PAE and brain size report no clear relationship. Some postnatal MRI studies reported smaller thalami, amygdalae and hippocampi in alcohol exposed neonates. Postnatal DTI studies (n = 5) examining network integrity and connectivity reported bidirectional results in multiple brain networks. Our results highlight the need for further research on first trimester brain development, timing and quantity of alcohol exposure using a core set of validated instruments. Longitudinal assessments and standardized procedures for neuroimaging are crucial to understand the impact of PAE on early brain development.</description><identifier>ISSN: 0197-3851</identifier><identifier>ISSN: 1097-0223</identifier><identifier>EISSN: 1097-0223</identifier><identifier>DOI: 10.1002/pd.6694</identifier><identifier>PMID: 39439004</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Alcohol ; Alcohol Drinking - adverse effects ; Alcohols ; Brain ; Brain - diagnostic imaging ; Brain - drug effects ; Brain - growth & development ; Diffusion Tensor Imaging ; ethanol ; Exposure ; Female ; first 1000 days ; Hippocampus ; Humans ; Infant ; Infant, Newborn ; Literature reviews ; Magnetic Resonance Imaging ; Medical imaging ; Neonates ; Neural networks ; neurodevelopment ; Neuroimaging ; Offspring ; Postpartum period ; Pregnancy ; prenatal alcohol exposure ; Prenatal experience ; Prenatal Exposure Delayed Effects - chemically induced ; Prenatal Exposure Delayed Effects - diagnostic imaging ; Review ; Systematic review ; Tensors ; Ultrasonic imaging ; Ultrasound</subject><ispartof>Prenatal diagnosis, 2024-12, Vol.44 (13), p.1603-1613</ispartof><rights>2024 The Author(s). published by John Wiley & Sons Ltd.</rights><rights>2024 The Author(s). Prenatal Diagnosis published by John Wiley & Sons Ltd.</rights><rights>2024. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3264-1cb07e3eb9f2d81b6915e70a0e8be3533812a516832c97f74051612c83b91e333</cites><orcidid>0000-0002-9763-5015</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpd.6694$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpd.6694$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39439004$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pielage, Marin</creatorcontrib><creatorcontrib>Rousian, Melek</creatorcontrib><creatorcontrib>Heteren, Sem</creatorcontrib><creatorcontrib>Groenenberg, Irene A. L.</creatorcontrib><creatorcontrib>Hillegers, Manon H. J.</creatorcontrib><creatorcontrib>Steegers, Eric A. P.</creatorcontrib><creatorcontrib>Marroun, Hanan El</creatorcontrib><title>The Association of Prenatal Alcohol Exposure With Brain Development During the First 1000 Days of Life: A Systematic Review</title><title>Prenatal diagnosis</title><addtitle>Prenat Diagn</addtitle><description>ABSTRACT
Prenatal exposure to alcohol (PAE) can impact short‐ and long‐term offspring health. However, knowledge on PAE and brain development in early life is limited. This systematic review investigated associations between PAE and brain development during the first 1000 days of life, and was registered in PROSPERO at CRD42022355144. The literature search was performed from inception until February 2024 in EMBASE, MEDLINE, Web of Science, PsycINFO, and the Cochrane Library. Studies investigating PAE and brain development during the first 1000 days using ultrasound, magnetic resonance imaging (MRI) or diffusion tensor imaging (DTI) were included. Our search initially identified 3618 articles, of which 16 were included. The findings suggest inconsistent associations between PAE and early brain development. Ultrasound studies on PAE and brain size report no clear relationship. Some postnatal MRI studies reported smaller thalami, amygdalae and hippocampi in alcohol exposed neonates. Postnatal DTI studies (n = 5) examining network integrity and connectivity reported bidirectional results in multiple brain networks. Our results highlight the need for further research on first trimester brain development, timing and quantity of alcohol exposure using a core set of validated instruments. Longitudinal assessments and standardized procedures for neuroimaging are crucial to understand the impact of PAE on early brain development.</description><subject>Alcohol</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Alcohols</subject><subject>Brain</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - drug effects</subject><subject>Brain - growth & development</subject><subject>Diffusion Tensor Imaging</subject><subject>ethanol</subject><subject>Exposure</subject><subject>Female</subject><subject>first 1000 days</subject><subject>Hippocampus</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Literature reviews</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical imaging</subject><subject>Neonates</subject><subject>Neural networks</subject><subject>neurodevelopment</subject><subject>Neuroimaging</subject><subject>Offspring</subject><subject>Postpartum period</subject><subject>Pregnancy</subject><subject>prenatal alcohol exposure</subject><subject>Prenatal experience</subject><subject>Prenatal Exposure Delayed Effects - chemically induced</subject><subject>Prenatal Exposure Delayed Effects - diagnostic imaging</subject><subject>Review</subject><subject>Systematic review</subject><subject>Tensors</subject><subject>Ultrasonic imaging</subject><subject>Ultrasound</subject><issn>0197-3851</issn><issn>1097-0223</issn><issn>1097-0223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp1kd1qFDEYhoModq3iHUjAgwqyNV8yf-mJbLutCgsWrXgYMtlvuimZyZjMbF3wYryWXlmzbi0qeJSEPDx5872EPAd2CIzxN_3ysChk9oBMgMlyyjgXD8mEQdqLKoc98iTGqwRWXJaPyZ6QmZCMZRPy42KFdBajN1YP1nfUN_Q8YKcH7ejMGb_yjp5-730cA9KvdljR46BtR-e4Ruf7FruBzsdgu0s6JNWZDXGgKRO7-TnXm7j1LWyDR3RGP2_igG16xtBPuLZ4_ZQ8arSL-Oxu3Sdfzk4vTt5PFx_ffTiZLaZG8CKbgqlZiQJr2fBlBXUhIceSaYZVjSIXogKucygqwY0smzJj6QDcVKKWgEKIffJ25-3HusWlSZmDdqoPttVho7y26u-bzq7UpV8rgCKNDLJkeHVnCP7biHFQrY0GndMd-jEqAWnUPM8rSOjLf9ArP4Yu_S9RGRc5gCgSdbCjTPAxBmzu0wBT20pVv1TbShP54s_w99zvDhPwegdcW4eb_3nU-fyX7hbV0ai3</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Pielage, Marin</creator><creator>Rousian, Melek</creator><creator>Heteren, Sem</creator><creator>Groenenberg, Irene A. 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Prenatal exposure to alcohol (PAE) can impact short‐ and long‐term offspring health. However, knowledge on PAE and brain development in early life is limited. This systematic review investigated associations between PAE and brain development during the first 1000 days of life, and was registered in PROSPERO at CRD42022355144. The literature search was performed from inception until February 2024 in EMBASE, MEDLINE, Web of Science, PsycINFO, and the Cochrane Library. Studies investigating PAE and brain development during the first 1000 days using ultrasound, magnetic resonance imaging (MRI) or diffusion tensor imaging (DTI) were included. Our search initially identified 3618 articles, of which 16 were included. The findings suggest inconsistent associations between PAE and early brain development. Ultrasound studies on PAE and brain size report no clear relationship. Some postnatal MRI studies reported smaller thalami, amygdalae and hippocampi in alcohol exposed neonates. Postnatal DTI studies (n = 5) examining network integrity and connectivity reported bidirectional results in multiple brain networks. Our results highlight the need for further research on first trimester brain development, timing and quantity of alcohol exposure using a core set of validated instruments. Longitudinal assessments and standardized procedures for neuroimaging are crucial to understand the impact of PAE on early brain development.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>39439004</pmid><doi>10.1002/pd.6694</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-9763-5015</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Alcohol Alcohol Drinking - adverse effects Alcohols Brain Brain - diagnostic imaging Brain - drug effects Brain - growth & development Diffusion Tensor Imaging ethanol Exposure Female first 1000 days Hippocampus Humans Infant Infant, Newborn Literature reviews Magnetic Resonance Imaging Medical imaging Neonates Neural networks neurodevelopment Neuroimaging Offspring Postpartum period Pregnancy prenatal alcohol exposure Prenatal experience Prenatal Exposure Delayed Effects - chemically induced Prenatal Exposure Delayed Effects - diagnostic imaging Review Systematic review Tensors Ultrasonic imaging Ultrasound |
| title | The Association of Prenatal Alcohol Exposure With Brain Development During the First 1000 Days of Life: A Systematic Review |
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