Exploring the Impact of Biological Agents on Protecting Against Experimental Periodontitis: A Systematic Review of Animal-Based Studies
This systematic review was aimed at addressing the focused question: What is the protective potential of biological agents against alveolar bone resorption during the progression of experimental periodontitis (EP)? The study protocol was registered in the Open Science Framework database (doi:10.1760...
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| creator | Oliveira, Gabriela Ezequiel da Silva Barbirato, Davi de Menezes, Bruna Silva Fuly, Milenna Silva Pelegrine, Henrique Cassebe Ledo Bonilha, Debora Caliendo de Alencar, Julia Gabrielle Pereira Theodoro, Leticia Helena de Molon, Rafael Scaf |
| description | This systematic review was aimed at addressing the focused question: What is the protective potential of biological agents against alveolar bone resorption during the progression of experimental periodontitis (EP)?
The study protocol was registered in the Open Science Framework database (doi:10.17605/OSF.IO/3P2HY). A comprehensive literature search was conducted across PubMed, Web of Science, Cochrane Library, Scopus, and Embase databases up to December 2023. Inclusion criteria consisted of preclinical studies in animal models of EP that examined the effects of biological agents on preventing periodontal bone loss and reducing tissue inflammation. Studies were excluded if they (i) used non-EP animal models; (ii) focused on antimicrobial agents; (iii) centered on prebiotics or probiotics; (iv) evaluated compounds not classified as biologicals; or (v) included randomized clinical trials, clinical studies, or reviews. Eligibility was determined based on the PI/ECOs framework, and study quality was assessed using the SYRCLE risk-of-bias tool.
After screening an initial pool of 5236 records from databases, registries, and hand searches, 39 studies met the inclusion criteria. A total of 23 biological agents were evaluated across these studies. The majority of studies employed the ligature-induced model of EP to test the effectiveness of biologicals as preventive or therapeutic interventions. The dosage of biological agents and the duration of disease induction varied depending on the EP model. In all studies, the main outcome-alveolar bone loss, a hallmark of EP-was significantly inhibited by biological agents, which also reduced proinflammatory mediators when compared to untreated controls. A key strength of this review is the high number of studies included, most of which were classified as having low risk of bias. However, a notable limitation is the absence of a meta-analysis, the short follow-up periods in the included studies, and the heterogeneity among the compound dosages and route of administration.
This systematic review demonstrates that biological agents are effective in reducing bone loss and mitigating inflammation during EP progression. Randomized clinical trials are needed to confirm these findings in human populations. |
| doi_str_mv | 10.1155/bmri/1716735 |
| format | Article |
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The study protocol was registered in the Open Science Framework database (doi:10.17605/OSF.IO/3P2HY). A comprehensive literature search was conducted across PubMed, Web of Science, Cochrane Library, Scopus, and Embase databases up to December 2023. Inclusion criteria consisted of preclinical studies in animal models of EP that examined the effects of biological agents on preventing periodontal bone loss and reducing tissue inflammation. Studies were excluded if they (i) used non-EP animal models; (ii) focused on antimicrobial agents; (iii) centered on prebiotics or probiotics; (iv) evaluated compounds not classified as biologicals; or (v) included randomized clinical trials, clinical studies, or reviews. Eligibility was determined based on the PI/ECOs framework, and study quality was assessed using the SYRCLE risk-of-bias tool.
After screening an initial pool of 5236 records from databases, registries, and hand searches, 39 studies met the inclusion criteria. A total of 23 biological agents were evaluated across these studies. The majority of studies employed the ligature-induced model of EP to test the effectiveness of biologicals as preventive or therapeutic interventions. The dosage of biological agents and the duration of disease induction varied depending on the EP model. In all studies, the main outcome-alveolar bone loss, a hallmark of EP-was significantly inhibited by biological agents, which also reduced proinflammatory mediators when compared to untreated controls. A key strength of this review is the high number of studies included, most of which were classified as having low risk of bias. However, a notable limitation is the absence of a meta-analysis, the short follow-up periods in the included studies, and the heterogeneity among the compound dosages and route of administration.
This systematic review demonstrates that biological agents are effective in reducing bone loss and mitigating inflammation during EP progression. Randomized clinical trials are needed to confirm these findings in human populations.</description><identifier>ISSN: 2314-6133</identifier><identifier>ISSN: 2314-6141</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/bmri/1716735</identifier><identifier>PMID: 39654845</identifier><language>eng</language><publisher>United States: Hindawi Limited</publisher><subject>Alveolar Bone Loss - drug therapy ; Alveolar Bone Loss - prevention & control ; Animal models ; Animals ; Biofilms ; Biological effects ; Biological Factors - pharmacology ; Biological Factors - therapeutic use ; Bone resorption ; Chronic illnesses ; Clinical trials ; Cytokines ; Diabetes ; Disease Models, Animal ; Disease prevention ; Enzymes ; Grey literature ; Gum disease ; Humans ; Immune response ; Inflammation ; Laboratory animals ; Molecular modelling ; Osteoclastogenesis ; Periodontitis ; Periodontitis - drug therapy ; Periodontitis - prevention & control ; Probiotics - therapeutic use ; Public health ; Quality of life ; Review ; Rheumatoid arthritis ; Root resorption ; Systematic review ; Systemic diseases ; Teeth ; Tumor necrosis factor-TNF</subject><ispartof>BioMed research international, 2024, Vol.2024 (1), p.1716735</ispartof><rights>Copyright © 2024 Gabriela Ezequiel Oliveira et al.</rights><rights>Copyright © 2024 Gabriela Ezequiel Oliveira et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2024 Gabriela Ezequiel Oliveira et al. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c300t-24f3e1ea794271811295d4e7ac4bc27de1e97056162c76fdbe497e62df7b92073</cites><orcidid>0000-0003-0527-6092 ; 0000-0003-4417-3950 ; 0009-0004-1042-2335 ; 0009-0002-1176-819X ; 0009-0006-5804-469X ; 0000-0003-3026-8369 ; 0000-0003-1110-6233</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11628168/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11628168/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39654845$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Fu-Ming Tsai</contributor><creatorcontrib>Oliveira, Gabriela Ezequiel</creatorcontrib><creatorcontrib>da Silva Barbirato, Davi</creatorcontrib><creatorcontrib>de Menezes, Bruna Silva</creatorcontrib><creatorcontrib>Fuly, Milenna Silva</creatorcontrib><creatorcontrib>Pelegrine, Henrique Cassebe Ledo</creatorcontrib><creatorcontrib>Bonilha, Debora Caliendo</creatorcontrib><creatorcontrib>de Alencar, Julia Gabrielle Pereira</creatorcontrib><creatorcontrib>Theodoro, Leticia Helena</creatorcontrib><creatorcontrib>de Molon, Rafael Scaf</creatorcontrib><title>Exploring the Impact of Biological Agents on Protecting Against Experimental Periodontitis: A Systematic Review of Animal-Based Studies</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>This systematic review was aimed at addressing the focused question: What is the protective potential of biological agents against alveolar bone resorption during the progression of experimental periodontitis (EP)?
The study protocol was registered in the Open Science Framework database (doi:10.17605/OSF.IO/3P2HY). A comprehensive literature search was conducted across PubMed, Web of Science, Cochrane Library, Scopus, and Embase databases up to December 2023. Inclusion criteria consisted of preclinical studies in animal models of EP that examined the effects of biological agents on preventing periodontal bone loss and reducing tissue inflammation. Studies were excluded if they (i) used non-EP animal models; (ii) focused on antimicrobial agents; (iii) centered on prebiotics or probiotics; (iv) evaluated compounds not classified as biologicals; or (v) included randomized clinical trials, clinical studies, or reviews. Eligibility was determined based on the PI/ECOs framework, and study quality was assessed using the SYRCLE risk-of-bias tool.
After screening an initial pool of 5236 records from databases, registries, and hand searches, 39 studies met the inclusion criteria. A total of 23 biological agents were evaluated across these studies. The majority of studies employed the ligature-induced model of EP to test the effectiveness of biologicals as preventive or therapeutic interventions. The dosage of biological agents and the duration of disease induction varied depending on the EP model. In all studies, the main outcome-alveolar bone loss, a hallmark of EP-was significantly inhibited by biological agents, which also reduced proinflammatory mediators when compared to untreated controls. A key strength of this review is the high number of studies included, most of which were classified as having low risk of bias. However, a notable limitation is the absence of a meta-analysis, the short follow-up periods in the included studies, and the heterogeneity among the compound dosages and route of administration.
This systematic review demonstrates that biological agents are effective in reducing bone loss and mitigating inflammation during EP progression. Randomized clinical trials are needed to confirm these findings in human populations.</description><subject>Alveolar Bone Loss - drug therapy</subject><subject>Alveolar Bone Loss - prevention & control</subject><subject>Animal models</subject><subject>Animals</subject><subject>Biofilms</subject><subject>Biological effects</subject><subject>Biological Factors - pharmacology</subject><subject>Biological Factors - therapeutic use</subject><subject>Bone resorption</subject><subject>Chronic illnesses</subject><subject>Clinical trials</subject><subject>Cytokines</subject><subject>Diabetes</subject><subject>Disease Models, Animal</subject><subject>Disease prevention</subject><subject>Enzymes</subject><subject>Grey literature</subject><subject>Gum disease</subject><subject>Humans</subject><subject>Immune response</subject><subject>Inflammation</subject><subject>Laboratory animals</subject><subject>Molecular modelling</subject><subject>Osteoclastogenesis</subject><subject>Periodontitis</subject><subject>Periodontitis - drug therapy</subject><subject>Periodontitis - prevention & control</subject><subject>Probiotics - therapeutic use</subject><subject>Public health</subject><subject>Quality of life</subject><subject>Review</subject><subject>Rheumatoid arthritis</subject><subject>Root resorption</subject><subject>Systematic review</subject><subject>Systemic diseases</subject><subject>Teeth</subject><subject>Tumor necrosis factor-TNF</subject><issn>2314-6133</issn><issn>2314-6141</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkcFu1TAQRSNERau2O9bIEhsWhHpix07YoLQqUKkSFYW15TiT1FUSP2yn0C_gt3Ho46nUmxlpjq_mzs2yl0DfAZTlSTt5ewIShGTls-ygYMBzARye73rG9rPjEG5pehUIWosX2T6rRckrXh5kv89_bUbn7TyQeIPkYtpoE4nryal1oxus0SNpBpxjIG4mV95FNHGlm0HbOUSS_qO3UyISeZVa17k52mjDe9KQ6_sQcdLRGvIV7yz-XKWb2U56zE91wI5cx6WzGI6yvV6PAY-39TD7_vH829nn_PLLp4uz5jI3jNKYF7xnCKhlzQsJFUBRlx1HqQ1vTSG7NKslLQWIwkjRdy3yWqIoul62dUElO8w-POhulnbCzqS9vR7VJlnQ_l45bdX_k9neqMHdKUiS6X5VUnizVfDux4IhqskGg-OoZ3RLUOnsQgDQv-jrJ-itW_yc_K0Ul1BCJRL19oEy3oXgsd9tA1StKas1ZbVNOeGvHjvYwf8yZX8APxGkpg</recordid><startdate>2024</startdate><enddate>2024</enddate><creator>Oliveira, Gabriela Ezequiel</creator><creator>da Silva Barbirato, Davi</creator><creator>de Menezes, Bruna Silva</creator><creator>Fuly, Milenna Silva</creator><creator>Pelegrine, Henrique Cassebe Ledo</creator><creator>Bonilha, Debora Caliendo</creator><creator>de Alencar, Julia Gabrielle Pereira</creator><creator>Theodoro, Leticia Helena</creator><creator>de Molon, Rafael Scaf</creator><general>Hindawi Limited</general><general>Wiley</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0527-6092</orcidid><orcidid>https://orcid.org/0000-0003-4417-3950</orcidid><orcidid>https://orcid.org/0009-0004-1042-2335</orcidid><orcidid>https://orcid.org/0009-0002-1176-819X</orcidid><orcidid>https://orcid.org/0009-0006-5804-469X</orcidid><orcidid>https://orcid.org/0000-0003-3026-8369</orcidid><orcidid>https://orcid.org/0000-0003-1110-6233</orcidid></search><sort><creationdate>2024</creationdate><title>Exploring the Impact of Biological Agents on Protecting Against Experimental Periodontitis: A Systematic Review of Animal-Based Studies</title><author>Oliveira, Gabriela Ezequiel ; da Silva Barbirato, Davi ; de Menezes, Bruna Silva ; Fuly, Milenna Silva ; Pelegrine, Henrique Cassebe Ledo ; Bonilha, Debora Caliendo ; de Alencar, Julia Gabrielle Pereira ; Theodoro, Leticia Helena ; de Molon, Rafael Scaf</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c300t-24f3e1ea794271811295d4e7ac4bc27de1e97056162c76fdbe497e62df7b92073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Alveolar Bone Loss - drug therapy</topic><topic>Alveolar Bone Loss - prevention & control</topic><topic>Animal models</topic><topic>Animals</topic><topic>Biofilms</topic><topic>Biological effects</topic><topic>Biological Factors - pharmacology</topic><topic>Biological Factors - therapeutic use</topic><topic>Bone resorption</topic><topic>Chronic illnesses</topic><topic>Clinical trials</topic><topic>Cytokines</topic><topic>Diabetes</topic><topic>Disease Models, Animal</topic><topic>Disease prevention</topic><topic>Enzymes</topic><topic>Grey literature</topic><topic>Gum disease</topic><topic>Humans</topic><topic>Immune response</topic><topic>Inflammation</topic><topic>Laboratory animals</topic><topic>Molecular modelling</topic><topic>Osteoclastogenesis</topic><topic>Periodontitis</topic><topic>Periodontitis - drug therapy</topic><topic>Periodontitis - prevention & control</topic><topic>Probiotics - therapeutic use</topic><topic>Public health</topic><topic>Quality of life</topic><topic>Review</topic><topic>Rheumatoid arthritis</topic><topic>Root resorption</topic><topic>Systematic review</topic><topic>Systemic diseases</topic><topic>Teeth</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oliveira, Gabriela Ezequiel</creatorcontrib><creatorcontrib>da Silva Barbirato, Davi</creatorcontrib><creatorcontrib>de Menezes, Bruna Silva</creatorcontrib><creatorcontrib>Fuly, Milenna Silva</creatorcontrib><creatorcontrib>Pelegrine, Henrique Cassebe Ledo</creatorcontrib><creatorcontrib>Bonilha, Debora Caliendo</creatorcontrib><creatorcontrib>de Alencar, Julia Gabrielle Pereira</creatorcontrib><creatorcontrib>Theodoro, Leticia Helena</creatorcontrib><creatorcontrib>de Molon, Rafael Scaf</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oliveira, Gabriela Ezequiel</au><au>da Silva Barbirato, Davi</au><au>de Menezes, Bruna Silva</au><au>Fuly, Milenna Silva</au><au>Pelegrine, Henrique Cassebe Ledo</au><au>Bonilha, Debora Caliendo</au><au>de Alencar, Julia Gabrielle Pereira</au><au>Theodoro, Leticia Helena</au><au>de Molon, Rafael Scaf</au><au>Fu-Ming Tsai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exploring the Impact of Biological Agents on Protecting Against Experimental Periodontitis: A Systematic Review of Animal-Based Studies</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2024</date><risdate>2024</risdate><volume>2024</volume><issue>1</issue><spage>1716735</spage><pages>1716735-</pages><issn>2314-6133</issn><issn>2314-6141</issn><eissn>2314-6141</eissn><abstract>This systematic review was aimed at addressing the focused question: What is the protective potential of biological agents against alveolar bone resorption during the progression of experimental periodontitis (EP)?
The study protocol was registered in the Open Science Framework database (doi:10.17605/OSF.IO/3P2HY). A comprehensive literature search was conducted across PubMed, Web of Science, Cochrane Library, Scopus, and Embase databases up to December 2023. Inclusion criteria consisted of preclinical studies in animal models of EP that examined the effects of biological agents on preventing periodontal bone loss and reducing tissue inflammation. Studies were excluded if they (i) used non-EP animal models; (ii) focused on antimicrobial agents; (iii) centered on prebiotics or probiotics; (iv) evaluated compounds not classified as biologicals; or (v) included randomized clinical trials, clinical studies, or reviews. Eligibility was determined based on the PI/ECOs framework, and study quality was assessed using the SYRCLE risk-of-bias tool.
After screening an initial pool of 5236 records from databases, registries, and hand searches, 39 studies met the inclusion criteria. A total of 23 biological agents were evaluated across these studies. The majority of studies employed the ligature-induced model of EP to test the effectiveness of biologicals as preventive or therapeutic interventions. The dosage of biological agents and the duration of disease induction varied depending on the EP model. In all studies, the main outcome-alveolar bone loss, a hallmark of EP-was significantly inhibited by biological agents, which also reduced proinflammatory mediators when compared to untreated controls. A key strength of this review is the high number of studies included, most of which were classified as having low risk of bias. However, a notable limitation is the absence of a meta-analysis, the short follow-up periods in the included studies, and the heterogeneity among the compound dosages and route of administration.
This systematic review demonstrates that biological agents are effective in reducing bone loss and mitigating inflammation during EP progression. Randomized clinical trials are needed to confirm these findings in human populations.</abstract><cop>United States</cop><pub>Hindawi Limited</pub><pmid>39654845</pmid><doi>10.1155/bmri/1716735</doi><orcidid>https://orcid.org/0000-0003-0527-6092</orcidid><orcidid>https://orcid.org/0000-0003-4417-3950</orcidid><orcidid>https://orcid.org/0009-0004-1042-2335</orcidid><orcidid>https://orcid.org/0009-0002-1176-819X</orcidid><orcidid>https://orcid.org/0009-0006-5804-469X</orcidid><orcidid>https://orcid.org/0000-0003-3026-8369</orcidid><orcidid>https://orcid.org/0000-0003-1110-6233</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2314-6133 |
| ispartof | BioMed research international, 2024, Vol.2024 (1), p.1716735 |
| issn | 2314-6133 2314-6141 2314-6141 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11628168 |
| source | MEDLINE; Wiley Online Library Open Access; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Alveolar Bone Loss - drug therapy Alveolar Bone Loss - prevention & control Animal models Animals Biofilms Biological effects Biological Factors - pharmacology Biological Factors - therapeutic use Bone resorption Chronic illnesses Clinical trials Cytokines Diabetes Disease Models, Animal Disease prevention Enzymes Grey literature Gum disease Humans Immune response Inflammation Laboratory animals Molecular modelling Osteoclastogenesis Periodontitis Periodontitis - drug therapy Periodontitis - prevention & control Probiotics - therapeutic use Public health Quality of life Review Rheumatoid arthritis Root resorption Systematic review Systemic diseases Teeth Tumor necrosis factor-TNF |
| title | Exploring the Impact of Biological Agents on Protecting Against Experimental Periodontitis: A Systematic Review of Animal-Based Studies |
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