The flavonoid quercetin decreases ACE2 and TMPRSS2 expression but not SARS‐CoV‐2 infection in cultured human lung cells

Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) binds to angiotensin‐converting enzyme 2 (ACE2) on host cells, via its spike protein, and transmembrane protease, serine 2 (TMPRSS2) cleaves the spike‐ACE2 complex to facilitate virus entry. As rate‐limiting steps for virus entry, modulati...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	BioFactors (Oxford) 2024-11, Vol.50 (6), p.1268-1286
Hauptverfasser:	Houghton, Michael James, Balland, Eglantine, Gartner, Matthew James, Thomas, Belinda Jane, Subbarao, Kanta, Williamson, Gary
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM17 Adult air–liquid interface Angiotensin-Converting Enzyme 2 - genetics Angiotensin-Converting Enzyme 2 - metabolism apelin‐13 Betacoronavirus - drug effects Bronchi - cytology Bronchi - drug effects Bronchi - metabolism Bronchi - virology Calu‐3 Cell Line Cells, Cultured Coronavirus Infections - drug therapy Coronavirus Infections - metabolism Coronavirus Infections - virology COVID-19 - metabolism COVID-19 - virology COVID‐19 Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - virology estradiol Humans Lung - cytology Lung - drug effects Lung - metabolism Lung - virology Male Pandemics Peptidyl-Dipeptidase A - genetics Peptidyl-Dipeptidase A - metabolism Pneumonia, Viral - drug therapy Pneumonia, Viral - metabolism Pneumonia, Viral - virology polyphenol primary bronchial epithelial cells Quercetin - pharmacology SARS-CoV-2 - drug effects SARS-CoV-2 - pathogenicity Serine Endopeptidases - genetics Serine Endopeptidases - metabolism Virus Internalization - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!