Critical Convex‐Type ST Elevation Correlate With Ventricular Tachyarrhythmia in Takotsubo Cardiomyopathy
ABSTRACT Background Ventricular tachyarrhythmia (VT) occasionally occurred in patients with Takotsubo cardiomyopathy (TC). Two convex‐type ST elevations were significantly related to VT in coronary artery disease. Methods This study assessed the correlation between VT and critical ECG patterns, as w...
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description | ABSTRACT
Background
Ventricular tachyarrhythmia (VT) occasionally occurred in patients with Takotsubo cardiomyopathy (TC). Two convex‐type ST elevations were significantly related to VT in coronary artery disease.
Methods
This study assessed the correlation between VT and critical ECG patterns, as well other independent predictive factors of in‐hospital outcome. Fifty‐five consecutive patients fulfilled the diagnostic criteria of Takotsubo Italian Network (TIN) were retrospectively enrolled. The patients were classified into two groups according to their critical ECG patterns and VT occurrence. In‐hospital outcomes and influencing factors were analyzed.
Results
The incidence of VT was higher in the critical ECG group than in the Noncritical ECG group (43.8% vs. 2.6%, p |
doi_str_mv | 10.1002/clc.70056 |
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Background
Ventricular tachyarrhythmia (VT) occasionally occurred in patients with Takotsubo cardiomyopathy (TC). Two convex‐type ST elevations were significantly related to VT in coronary artery disease.
Methods
This study assessed the correlation between VT and critical ECG patterns, as well other independent predictive factors of in‐hospital outcome. Fifty‐five consecutive patients fulfilled the diagnostic criteria of Takotsubo Italian Network (TIN) were retrospectively enrolled. The patients were classified into two groups according to their critical ECG patterns and VT occurrence. In‐hospital outcomes and influencing factors were analyzed.
Results
The incidence of VT was higher in the critical ECG group than in the Noncritical ECG group (43.8% vs. 2.6%, p < 0.001). In‐hospital death was more common in the critical ECG group than in the Noncritical ECG group (25.0% vs. 5.1%, p = 0.032). The composite end‐point (combined VT and in‐hospital death) revealed significant differences between these two groups (50.0% vs 7.7%, p < 0.001). Multi‐variate analysis proved critical ECG type as one independent risk factor of VT (odds ratio [OR] = 61.8, p = 0.009) and the composite end‐point (OR = 12.4, p = 0.007). The prolong QRS width ( ≥ 105 ms) was another independent factor for predicting VT (OR = 1.06, p = 0.022) and composite end‐point (OR = 1.05, p = 0.017).
Conclusions
Critical ECG types including tombstoning ST elevation and lambda‐wave ST elevation have strong impact on short‐term outcomes. Additionally, conduction disturbance with prolong QRS ≥ 105 ms also has independent predicting role for poor prognosis.
Ventricular tachyarrhythmia (VT) occasionally occurred in patients with Takotsubo cardiomyopathy (TC). This study assessed the correlation between VT and critical ECG patterns. Critical ECG types including tombstoning ST elevation and lambda‐wave ST elevation have strong impact on short‐term outcomes.
Summary
Key findings
Both critical ECG types and prolong QRS 105 ms had independent predicting role for poor prognosis in patients with stress‐induced cardiomyopathy.
What is known and what is new?
An lambda‐wave ST elevation and tombstoning ST elevation may predict malignant arrhythmias in patients with CAD and STEMI.
For patients with stress‐induced cardiomyopathy, the critical ECG types including tombstoning ST elevation and lambda‐wave ST elevation had strong impact for VT and in‐hospital death.
What is the implication, and what should change now?
Above abnormal ECG signs identifying high‐risk patients and implementing close monitoring and aggressive interventions.</description><identifier>ISSN: 0160-9289</identifier><identifier>ISSN: 1932-8737</identifier><identifier>EISSN: 1932-8737</identifier><identifier>DOI: 10.1002/clc.70056</identifier><identifier>PMID: 39648966</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Aged ; Aged, 80 and over ; Beta blockers ; Cardiac arrest ; Cardiac arrhythmia ; Cardiomyopathy ; Cardiovascular disease ; Chronic obstructive pulmonary disease ; Clinical ; convex‐type ST elevation ; Coronary vessels ; Diabetes ; Dopamine ; Edema ; Ejection fraction ; Electrocardiography ; Enzymes ; Female ; Females ; Heart Rate - physiology ; Hospital Mortality ; Hospitalization ; Humans ; Hypertension ; Incidence ; lambda‐wave ST elevation ; Male ; Middle Aged ; Patients ; Predictive Value of Tests ; Prognosis ; Retrospective Studies ; Risk Factors ; Tachycardia, Ventricular - diagnosis ; Tachycardia, Ventricular - epidemiology ; Tachycardia, Ventricular - etiology ; Tachycardia, Ventricular - mortality ; Tachycardia, Ventricular - physiopathology ; takotsubo cardiomyopathy ; Takotsubo Cardiomyopathy - complications ; Takotsubo Cardiomyopathy - diagnosis ; Takotsubo Cardiomyopathy - epidemiology ; Takotsubo Cardiomyopathy - mortality ; Takotsubo Cardiomyopathy - physiopathology ; tombstoning ST elevation ; Ventilators ; ventricular tachyarrhythmia</subject><ispartof>Clinical cardiology (Mahwah, N.J.), 2024-12, Vol.47 (12), p.e70056-n/a</ispartof><rights>2024 The Author(s). published by Wiley Periodicals, LLC.</rights><rights>2024 The Author(s). Clinical Cardiology published by Wiley Periodicals, LLC.</rights><rights>2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2996-d8bbaf956e9452347fd72f1cd8e817172e347abc37e06e507dff526f2a78701c3</cites><orcidid>0000-0002-6073-102X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626252/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626252/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39648966$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hsu, Jen‐Te</creatorcontrib><creatorcontrib>Hsiao, Ju‐Feng</creatorcontrib><creatorcontrib>Chin, See‐Khong</creatorcontrib><creatorcontrib>Hsu, Yu‐Cheng</creatorcontrib><creatorcontrib>Lei, Meng‐Huan</creatorcontrib><title>Critical Convex‐Type ST Elevation Correlate With Ventricular Tachyarrhythmia in Takotsubo Cardiomyopathy</title><title>Clinical cardiology (Mahwah, N.J.)</title><addtitle>Clin Cardiol</addtitle><description>ABSTRACT
Background
Ventricular tachyarrhythmia (VT) occasionally occurred in patients with Takotsubo cardiomyopathy (TC). Two convex‐type ST elevations were significantly related to VT in coronary artery disease.
Methods
This study assessed the correlation between VT and critical ECG patterns, as well other independent predictive factors of in‐hospital outcome. Fifty‐five consecutive patients fulfilled the diagnostic criteria of Takotsubo Italian Network (TIN) were retrospectively enrolled. The patients were classified into two groups according to their critical ECG patterns and VT occurrence. In‐hospital outcomes and influencing factors were analyzed.
Results
The incidence of VT was higher in the critical ECG group than in the Noncritical ECG group (43.8% vs. 2.6%, p < 0.001). In‐hospital death was more common in the critical ECG group than in the Noncritical ECG group (25.0% vs. 5.1%, p = 0.032). The composite end‐point (combined VT and in‐hospital death) revealed significant differences between these two groups (50.0% vs 7.7%, p < 0.001). Multi‐variate analysis proved critical ECG type as one independent risk factor of VT (odds ratio [OR] = 61.8, p = 0.009) and the composite end‐point (OR = 12.4, p = 0.007). The prolong QRS width ( ≥ 105 ms) was another independent factor for predicting VT (OR = 1.06, p = 0.022) and composite end‐point (OR = 1.05, p = 0.017).
Conclusions
Critical ECG types including tombstoning ST elevation and lambda‐wave ST elevation have strong impact on short‐term outcomes. Additionally, conduction disturbance with prolong QRS ≥ 105 ms also has independent predicting role for poor prognosis.
Ventricular tachyarrhythmia (VT) occasionally occurred in patients with Takotsubo cardiomyopathy (TC). This study assessed the correlation between VT and critical ECG patterns. Critical ECG types including tombstoning ST elevation and lambda‐wave ST elevation have strong impact on short‐term outcomes.
Summary
Key findings
Both critical ECG types and prolong QRS 105 ms had independent predicting role for poor prognosis in patients with stress‐induced cardiomyopathy.
What is known and what is new?
An lambda‐wave ST elevation and tombstoning ST elevation may predict malignant arrhythmias in patients with CAD and STEMI.
For patients with stress‐induced cardiomyopathy, the critical ECG types including tombstoning ST elevation and lambda‐wave ST elevation had strong impact for VT and in‐hospital death.
What is the implication, and what should change now?
Above abnormal ECG signs identifying high‐risk patients and implementing close monitoring and aggressive interventions.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Beta blockers</subject><subject>Cardiac arrest</subject><subject>Cardiac arrhythmia</subject><subject>Cardiomyopathy</subject><subject>Cardiovascular disease</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Clinical</subject><subject>convex‐type ST elevation</subject><subject>Coronary vessels</subject><subject>Diabetes</subject><subject>Dopamine</subject><subject>Edema</subject><subject>Ejection fraction</subject><subject>Electrocardiography</subject><subject>Enzymes</subject><subject>Female</subject><subject>Females</subject><subject>Heart Rate - physiology</subject><subject>Hospital Mortality</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Incidence</subject><subject>lambda‐wave ST elevation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Tachycardia, Ventricular - diagnosis</subject><subject>Tachycardia, Ventricular - epidemiology</subject><subject>Tachycardia, Ventricular - etiology</subject><subject>Tachycardia, Ventricular - mortality</subject><subject>Tachycardia, Ventricular - physiopathology</subject><subject>takotsubo cardiomyopathy</subject><subject>Takotsubo Cardiomyopathy - complications</subject><subject>Takotsubo Cardiomyopathy - diagnosis</subject><subject>Takotsubo Cardiomyopathy - epidemiology</subject><subject>Takotsubo Cardiomyopathy - mortality</subject><subject>Takotsubo Cardiomyopathy - physiopathology</subject><subject>tombstoning ST elevation</subject><subject>Ventilators</subject><subject>ventricular tachyarrhythmia</subject><issn>0160-9289</issn><issn>1932-8737</issn><issn>1932-8737</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kcGO0zAQhi0EYkvhwAugSFzYQ3ZtJ7HjE0LRLiBV4kCBo-U4E-LixMV2CrnxCDwjT4JLlxUgcRpp5tM__8yP0GOCLwjG9FJbfcExrtgdtCKioHnNC34XrTBhOBe0FmfoQQi7hOKaFvfRWSFYWQvGVmjXeBONVjZr3HSArz--fd8ue8jebrMrCwcVjZvSyHuwKkL2wcQhew9T9EbPVvlsq_SwKO-HJQ6jUZmZUuuTi2FuXdYo3xk3Lm6v4rA8RPd6ZQM8uqlr9O76atu8yjdvXr5uXmxyTYVgeVe3repFxUCUFS1K3nec9kR3NdSEE04h9VSrCw6YQYV51_cVZT1VvOaY6GKNnp9093M7QqePbpWVe29G5RfplJF_TyYzyI_uIAlhlNG0c42e3Sh493mGEOVoggZr1QRuDrIgJavSJwue0Kf_oDs3-yndd6Q45aUQJFHnJ0p7F4KH_tYNwfIYoUwRyl8RJvbJn_Zvyd-ZJeDyBHwxFpb_K8lm05wkfwKvi6ha</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Hsu, Jen‐Te</creator><creator>Hsiao, Ju‐Feng</creator><creator>Chin, See‐Khong</creator><creator>Hsu, Yu‐Cheng</creator><creator>Lei, Meng‐Huan</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6073-102X</orcidid></search><sort><creationdate>202412</creationdate><title>Critical Convex‐Type ST Elevation Correlate With Ventricular Tachyarrhythmia in Takotsubo Cardiomyopathy</title><author>Hsu, Jen‐Te ; Hsiao, Ju‐Feng ; Chin, See‐Khong ; Hsu, Yu‐Cheng ; Lei, Meng‐Huan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2996-d8bbaf956e9452347fd72f1cd8e817172e347abc37e06e507dff526f2a78701c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Beta blockers</topic><topic>Cardiac arrest</topic><topic>Cardiac arrhythmia</topic><topic>Cardiomyopathy</topic><topic>Cardiovascular disease</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Clinical</topic><topic>convex‐type ST elevation</topic><topic>Coronary vessels</topic><topic>Diabetes</topic><topic>Dopamine</topic><topic>Edema</topic><topic>Ejection fraction</topic><topic>Electrocardiography</topic><topic>Enzymes</topic><topic>Female</topic><topic>Females</topic><topic>Heart Rate - physiology</topic><topic>Hospital Mortality</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Incidence</topic><topic>lambda‐wave ST elevation</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Patients</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Tachycardia, Ventricular - diagnosis</topic><topic>Tachycardia, Ventricular - epidemiology</topic><topic>Tachycardia, Ventricular - etiology</topic><topic>Tachycardia, Ventricular - mortality</topic><topic>Tachycardia, Ventricular - physiopathology</topic><topic>takotsubo cardiomyopathy</topic><topic>Takotsubo Cardiomyopathy - complications</topic><topic>Takotsubo Cardiomyopathy - diagnosis</topic><topic>Takotsubo Cardiomyopathy - epidemiology</topic><topic>Takotsubo Cardiomyopathy - mortality</topic><topic>Takotsubo Cardiomyopathy - physiopathology</topic><topic>tombstoning ST elevation</topic><topic>Ventilators</topic><topic>ventricular tachyarrhythmia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hsu, Jen‐Te</creatorcontrib><creatorcontrib>Hsiao, Ju‐Feng</creatorcontrib><creatorcontrib>Chin, See‐Khong</creatorcontrib><creatorcontrib>Hsu, Yu‐Cheng</creatorcontrib><creatorcontrib>Lei, Meng‐Huan</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical cardiology (Mahwah, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hsu, Jen‐Te</au><au>Hsiao, Ju‐Feng</au><au>Chin, See‐Khong</au><au>Hsu, Yu‐Cheng</au><au>Lei, Meng‐Huan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Critical Convex‐Type ST Elevation Correlate With Ventricular Tachyarrhythmia in Takotsubo Cardiomyopathy</atitle><jtitle>Clinical cardiology (Mahwah, N.J.)</jtitle><addtitle>Clin Cardiol</addtitle><date>2024-12</date><risdate>2024</risdate><volume>47</volume><issue>12</issue><spage>e70056</spage><epage>n/a</epage><pages>e70056-n/a</pages><issn>0160-9289</issn><issn>1932-8737</issn><eissn>1932-8737</eissn><abstract>ABSTRACT
Background
Ventricular tachyarrhythmia (VT) occasionally occurred in patients with Takotsubo cardiomyopathy (TC). Two convex‐type ST elevations were significantly related to VT in coronary artery disease.
Methods
This study assessed the correlation between VT and critical ECG patterns, as well other independent predictive factors of in‐hospital outcome. Fifty‐five consecutive patients fulfilled the diagnostic criteria of Takotsubo Italian Network (TIN) were retrospectively enrolled. The patients were classified into two groups according to their critical ECG patterns and VT occurrence. In‐hospital outcomes and influencing factors were analyzed.
Results
The incidence of VT was higher in the critical ECG group than in the Noncritical ECG group (43.8% vs. 2.6%, p < 0.001). In‐hospital death was more common in the critical ECG group than in the Noncritical ECG group (25.0% vs. 5.1%, p = 0.032). The composite end‐point (combined VT and in‐hospital death) revealed significant differences between these two groups (50.0% vs 7.7%, p < 0.001). Multi‐variate analysis proved critical ECG type as one independent risk factor of VT (odds ratio [OR] = 61.8, p = 0.009) and the composite end‐point (OR = 12.4, p = 0.007). The prolong QRS width ( ≥ 105 ms) was another independent factor for predicting VT (OR = 1.06, p = 0.022) and composite end‐point (OR = 1.05, p = 0.017).
Conclusions
Critical ECG types including tombstoning ST elevation and lambda‐wave ST elevation have strong impact on short‐term outcomes. Additionally, conduction disturbance with prolong QRS ≥ 105 ms also has independent predicting role for poor prognosis.
Ventricular tachyarrhythmia (VT) occasionally occurred in patients with Takotsubo cardiomyopathy (TC). This study assessed the correlation between VT and critical ECG patterns. Critical ECG types including tombstoning ST elevation and lambda‐wave ST elevation have strong impact on short‐term outcomes.
Summary
Key findings
Both critical ECG types and prolong QRS 105 ms had independent predicting role for poor prognosis in patients with stress‐induced cardiomyopathy.
What is known and what is new?
An lambda‐wave ST elevation and tombstoning ST elevation may predict malignant arrhythmias in patients with CAD and STEMI.
For patients with stress‐induced cardiomyopathy, the critical ECG types including tombstoning ST elevation and lambda‐wave ST elevation had strong impact for VT and in‐hospital death.
What is the implication, and what should change now?
Above abnormal ECG signs identifying high‐risk patients and implementing close monitoring and aggressive interventions.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>39648966</pmid><doi>10.1002/clc.70056</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-6073-102X</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Aged Aged, 80 and over Beta blockers Cardiac arrest Cardiac arrhythmia Cardiomyopathy Cardiovascular disease Chronic obstructive pulmonary disease Clinical convex‐type ST elevation Coronary vessels Diabetes Dopamine Edema Ejection fraction Electrocardiography Enzymes Female Females Heart Rate - physiology Hospital Mortality Hospitalization Humans Hypertension Incidence lambda‐wave ST elevation Male Middle Aged Patients Predictive Value of Tests Prognosis Retrospective Studies Risk Factors Tachycardia, Ventricular - diagnosis Tachycardia, Ventricular - epidemiology Tachycardia, Ventricular - etiology Tachycardia, Ventricular - mortality Tachycardia, Ventricular - physiopathology takotsubo cardiomyopathy Takotsubo Cardiomyopathy - complications Takotsubo Cardiomyopathy - diagnosis Takotsubo Cardiomyopathy - epidemiology Takotsubo Cardiomyopathy - mortality Takotsubo Cardiomyopathy - physiopathology tombstoning ST elevation Ventilators ventricular tachyarrhythmia |
title | Critical Convex‐Type ST Elevation Correlate With Ventricular Tachyarrhythmia in Takotsubo Cardiomyopathy |
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