Exploring subcortical pathology and processing speed in neuromyelitis optica spectrum disorder with myelin water imaging
Neuromyelitis optica spectrum disorder (NMOSD) affects the optic nerves and spinal cord but can also cause focal brain inflammation. Subcortical pathology may contribute to the etiology of cognitive deficits in NMOSD. Using myelin water imaging, we investigated cerebral normal-appearing white matter...
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| Veröffentlicht in: | Journal of neuroimaging 2024-11, Vol.35 (1), p.e13250 |
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| creator | Tsai, Chia-Chen Combes, Anna McMullen, Katrina Kolind, Shannon H Traboulsee, Anthony L |
| description | Neuromyelitis optica spectrum disorder (NMOSD) affects the optic nerves and spinal cord but can also cause focal brain inflammation. Subcortical pathology may contribute to the etiology of cognitive deficits in NMOSD. Using myelin water imaging, we investigated cerebral normal-appearing white matter (NAWM) and thalamic metrics and their association with cognition in NMOSD participants compared to healthy controls (HC).
Seventeen NMOSD participants and 21 HC were scanned on a 3.0-Tesla MRI scanner using a multicomponent driven-equilibrium single-pulse observation of T
and T
protocol. Tissue compartment and thalamic volumes (normalized to intracranial volume), T
relaxation time, and myelin water fraction (MWF) were reported. Eleven NMOSD participants underwent the Symbol Digit Modalities Test (SDMT) for cognitive evaluation. Group comparisons were performed using Student's t-test. The association between thalamic metrics and SDMT score was assessed using multiple regression analysis with age as a covariate.
Compared to HC, NMOSD participants had reduced white matter volume (-14.2%, p |
| doi_str_mv | 10.1111/jon.13250 |
| format | Article |
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Seventeen NMOSD participants and 21 HC were scanned on a 3.0-Tesla MRI scanner using a multicomponent driven-equilibrium single-pulse observation of T
and T
protocol. Tissue compartment and thalamic volumes (normalized to intracranial volume), T
relaxation time, and myelin water fraction (MWF) were reported. Eleven NMOSD participants underwent the Symbol Digit Modalities Test (SDMT) for cognitive evaluation. Group comparisons were performed using Student's t-test. The association between thalamic metrics and SDMT score was assessed using multiple regression analysis with age as a covariate.
Compared to HC, NMOSD participants had reduced white matter volume (-14.2%, p < .0001), increased T
relaxation time (+2.29%, p = .022), and lower MWF (-3.64%, p = .024) in NAWM. NMOSD group had a trend for smaller thalamic volumes than HC (-5.52%, p = .082) and no differences in thalamic MWF (p = .258) or T
(p = .714). Thalamic T
predicted SDMT score (adjusted R
= .51, p = .04) when controlling for age.
NAWM in NMOSD demonstrates diffuse abnormalities with increased water content and demyelination, suggesting a diffuse disease process overlooked by focal inflammation measures. Increased water content, as a biomarker for diffuse thalamic pathology, may partially explain cognitive impairment in NMOSD.</description><identifier>ISSN: 1051-2284</identifier><identifier>ISSN: 1552-6569</identifier><identifier>EISSN: 1552-6569</identifier><identifier>DOI: 10.1111/jon.13250</identifier><identifier>PMID: 39511966</identifier><language>eng</language><publisher>United States: John Wiley and Sons Inc</publisher><subject>Adult ; Clinical Investigative Study ; Female ; Humans ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Myelin Sheath - pathology ; Neuromyelitis Optica - diagnostic imaging ; Neuromyelitis Optica - pathology ; Processing Speed ; Thalamus - diagnostic imaging ; Thalamus - pathology ; White Matter - diagnostic imaging ; White Matter - pathology</subject><ispartof>Journal of neuroimaging, 2024-11, Vol.35 (1), p.e13250</ispartof><rights>2024 The Author(s). Journal of Neuroimaging published by Wiley Periodicals LLC on behalf of American Society of Neuroimaging.</rights><rights>2024 The Author(s). published by Wiley Periodicals LLC on behalf of American Society of Neuroimaging.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c266t-89fb3b3248dffd2d2e944bc81968d3442217185787372dc3c4ab148d19dfe9623</cites><orcidid>0000-0001-6907-1104</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39511966$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsai, Chia-Chen</creatorcontrib><creatorcontrib>Combes, Anna</creatorcontrib><creatorcontrib>McMullen, Katrina</creatorcontrib><creatorcontrib>Kolind, Shannon H</creatorcontrib><creatorcontrib>Traboulsee, Anthony L</creatorcontrib><title>Exploring subcortical pathology and processing speed in neuromyelitis optica spectrum disorder with myelin water imaging</title><title>Journal of neuroimaging</title><addtitle>J Neuroimaging</addtitle><description>Neuromyelitis optica spectrum disorder (NMOSD) affects the optic nerves and spinal cord but can also cause focal brain inflammation. Subcortical pathology may contribute to the etiology of cognitive deficits in NMOSD. Using myelin water imaging, we investigated cerebral normal-appearing white matter (NAWM) and thalamic metrics and their association with cognition in NMOSD participants compared to healthy controls (HC).
Seventeen NMOSD participants and 21 HC were scanned on a 3.0-Tesla MRI scanner using a multicomponent driven-equilibrium single-pulse observation of T
and T
protocol. Tissue compartment and thalamic volumes (normalized to intracranial volume), T
relaxation time, and myelin water fraction (MWF) were reported. Eleven NMOSD participants underwent the Symbol Digit Modalities Test (SDMT) for cognitive evaluation. Group comparisons were performed using Student's t-test. The association between thalamic metrics and SDMT score was assessed using multiple regression analysis with age as a covariate.
Compared to HC, NMOSD participants had reduced white matter volume (-14.2%, p < .0001), increased T
relaxation time (+2.29%, p = .022), and lower MWF (-3.64%, p = .024) in NAWM. NMOSD group had a trend for smaller thalamic volumes than HC (-5.52%, p = .082) and no differences in thalamic MWF (p = .258) or T
(p = .714). Thalamic T
predicted SDMT score (adjusted R
= .51, p = .04) when controlling for age.
NAWM in NMOSD demonstrates diffuse abnormalities with increased water content and demyelination, suggesting a diffuse disease process overlooked by focal inflammation measures. Increased water content, as a biomarker for diffuse thalamic pathology, may partially explain cognitive impairment in NMOSD.</description><subject>Adult</subject><subject>Clinical Investigative Study</subject><subject>Female</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myelin Sheath - pathology</subject><subject>Neuromyelitis Optica - diagnostic imaging</subject><subject>Neuromyelitis Optica - pathology</subject><subject>Processing Speed</subject><subject>Thalamus - diagnostic imaging</subject><subject>Thalamus - pathology</subject><subject>White Matter - diagnostic imaging</subject><subject>White Matter - pathology</subject><issn>1051-2284</issn><issn>1552-6569</issn><issn>1552-6569</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUtPAyEUhYnRWK0u_AOGpS6mDjBDZ1bGNPWRNHGja8IA09LMwAiMbf-99GGjbCD3fpx7cg8ANygdoXgeltaMEMF5egIuUJ7jhOa0PI3vNEcJxkU2AJfeL9MUowyTczAgZY5QSekFWE_XXWOdNnPo-0pYF7TgDex4WNjGzjeQGwk7Z4Xyfgd1SkmoDTSqd7bdqEYH7aHttv-2XRFc30KpvXVSObjSYQF3mIErHmJFt3wela7AWc0br64P9xB8Pk8_Jq_J7P3lbfI0SwSmNCRFWVekIjgrZF1LLLEqs6wSRXRfSJJlGKMxKvJxMSZjLAURGa9QhFEpa1VSTIbgca_b9VWrpFAmON6wzkUfbsMs1-x_x-gFm9tvhhDFcY15VLg7KDj71SsfWKu9UE3DjbK9ZwThIhqku2H3e1Q4671T9XEOStk2KhajYruoInv719iR_M2G_AAV_ZMb</recordid><startdate>20241107</startdate><enddate>20241107</enddate><creator>Tsai, Chia-Chen</creator><creator>Combes, Anna</creator><creator>McMullen, Katrina</creator><creator>Kolind, Shannon H</creator><creator>Traboulsee, Anthony L</creator><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6907-1104</orcidid></search><sort><creationdate>20241107</creationdate><title>Exploring subcortical pathology and processing speed in neuromyelitis optica spectrum disorder with myelin water imaging</title><author>Tsai, Chia-Chen ; Combes, Anna ; McMullen, Katrina ; Kolind, Shannon H ; Traboulsee, Anthony L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c266t-89fb3b3248dffd2d2e944bc81968d3442217185787372dc3c4ab148d19dfe9623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Clinical Investigative Study</topic><topic>Female</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myelin Sheath - pathology</topic><topic>Neuromyelitis Optica - diagnostic imaging</topic><topic>Neuromyelitis Optica - pathology</topic><topic>Processing Speed</topic><topic>Thalamus - diagnostic imaging</topic><topic>Thalamus - pathology</topic><topic>White Matter - diagnostic imaging</topic><topic>White Matter - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsai, Chia-Chen</creatorcontrib><creatorcontrib>Combes, Anna</creatorcontrib><creatorcontrib>McMullen, Katrina</creatorcontrib><creatorcontrib>Kolind, Shannon H</creatorcontrib><creatorcontrib>Traboulsee, Anthony L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neuroimaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsai, Chia-Chen</au><au>Combes, Anna</au><au>McMullen, Katrina</au><au>Kolind, Shannon H</au><au>Traboulsee, Anthony L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exploring subcortical pathology and processing speed in neuromyelitis optica spectrum disorder with myelin water imaging</atitle><jtitle>Journal of neuroimaging</jtitle><addtitle>J Neuroimaging</addtitle><date>2024-11-07</date><risdate>2024</risdate><volume>35</volume><issue>1</issue><spage>e13250</spage><pages>e13250-</pages><issn>1051-2284</issn><issn>1552-6569</issn><eissn>1552-6569</eissn><abstract>Neuromyelitis optica spectrum disorder (NMOSD) affects the optic nerves and spinal cord but can also cause focal brain inflammation. Subcortical pathology may contribute to the etiology of cognitive deficits in NMOSD. Using myelin water imaging, we investigated cerebral normal-appearing white matter (NAWM) and thalamic metrics and their association with cognition in NMOSD participants compared to healthy controls (HC).
Seventeen NMOSD participants and 21 HC were scanned on a 3.0-Tesla MRI scanner using a multicomponent driven-equilibrium single-pulse observation of T
and T
protocol. Tissue compartment and thalamic volumes (normalized to intracranial volume), T
relaxation time, and myelin water fraction (MWF) were reported. Eleven NMOSD participants underwent the Symbol Digit Modalities Test (SDMT) for cognitive evaluation. Group comparisons were performed using Student's t-test. The association between thalamic metrics and SDMT score was assessed using multiple regression analysis with age as a covariate.
Compared to HC, NMOSD participants had reduced white matter volume (-14.2%, p < .0001), increased T
relaxation time (+2.29%, p = .022), and lower MWF (-3.64%, p = .024) in NAWM. NMOSD group had a trend for smaller thalamic volumes than HC (-5.52%, p = .082) and no differences in thalamic MWF (p = .258) or T
(p = .714). Thalamic T
predicted SDMT score (adjusted R
= .51, p = .04) when controlling for age.
NAWM in NMOSD demonstrates diffuse abnormalities with increased water content and demyelination, suggesting a diffuse disease process overlooked by focal inflammation measures. Increased water content, as a biomarker for diffuse thalamic pathology, may partially explain cognitive impairment in NMOSD.</abstract><cop>United States</cop><pub>John Wiley and Sons Inc</pub><pmid>39511966</pmid><doi>10.1111/jon.13250</doi><orcidid>https://orcid.org/0000-0001-6907-1104</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Clinical Investigative Study Female Humans Magnetic Resonance Imaging - methods Male Middle Aged Myelin Sheath - pathology Neuromyelitis Optica - diagnostic imaging Neuromyelitis Optica - pathology Processing Speed Thalamus - diagnostic imaging Thalamus - pathology White Matter - diagnostic imaging White Matter - pathology |
| title | Exploring subcortical pathology and processing speed in neuromyelitis optica spectrum disorder with myelin water imaging |
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