NF-κB c-Rel is a critical regulator of TLR7-induced inflammation in psoriasis

Nuclear factor kappa B (NF-κB) c-Rel is a psoriasis susceptibility locus, however mechanisms underlying c-Rel transactivation during disease are poorly understood. Inflammation in psoriasis can be triggered following Toll-like Receptor 7 (TLR7) signalling in dendritic cells (DCs), and c-Rel is a cri...

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Veröffentlicht in:	EBioMedicine 2024-12, Vol.110, p.105452, Article 105452
Hauptverfasser:	Liu, Angela Rose, Sarkar, Nandini, Cress, Jordan D., de Jesus, Tristan J., Vadlakonda, Ananya, Centore, Joshua T., Griffith, Alexis D., Rohr, Bethany, McCormick, Thomas S., Cooper, Kevin D., Ramakrishnan, Parameswaran
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dendritic Cells - immunology Dendritic Cells - metabolism Disease Models, Animal Disease Susceptibility Humans Inflammation Inflammation - genetics Inflammation - metabolism Inflammation - pathology Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice Mice, Knockout NF-kappa B - metabolism NF-κB c-Rel Proto-Oncogene Proteins c-rel - genetics Proto-Oncogene Proteins c-rel - metabolism Psoriasis Psoriasis - chemically induced Psoriasis - etiology Psoriasis - genetics Psoriasis - metabolism Psoriasis - pathology Signal Transduction Skin - metabolism Skin - pathology TLR7 Toll-Like Receptor 7 - genetics Toll-Like Receptor 7 - metabolism Transcription
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