Loss of O-GlcNAcylation modulates mTORC1 and autophagy in β cells, driving diabetes 2 progression

Type 2 diabetes (T2D) arises when pancreatic β cells fail to produce sufficient insulin to control blood glucose appropriately. Aberrant nutrient sensing by O-GlcNAcylation and mTORC1 is linked to T2D and the failure of insulin-producing β cells. However, the nature of their crosstalk in β cells rem...

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Veröffentlicht in:	JCI insight 2024-12, Vol.9 (23)
Hauptverfasser:	Jo, Seokwon, Esch, Nicholas, Nguyen, Anh, Wong, Alicia, Mohan, Ramkumar, Kim, Clara, Blandino-Rosano, Manuel, Bernal-Mizrachi, Ernesto, Alejandro, Emilyn U
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy - physiology Diabetes Mellitus, Type 2 - metabolism Disease Progression Humans Insulin - metabolism Insulin-Secreting Cells - metabolism Male Mechanistic Target of Rapamycin Complex 1 - metabolism Mice Mice, Knockout N-Acetylglucosaminyltransferases - genetics N-Acetylglucosaminyltransferases - metabolism Obesity - metabolism Signal Transduction
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