The Spx stress regulator confers high-level β-lactam resistance and decreases susceptibility to last-line antibiotics in methicillin-resistant Staphylococcus aureus

Infections caused by methicillin-resistant (MRSA) are a leading cause of mortality worldwide. MRSA has acquired resistance to next-generation β-lactam antibiotics through the horizontal acquisition of the resistance gene. Development of high resistance is, however, often associated with additional m...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2024-05, Vol.68 (6), p.e0033524-e0033524
Hauptverfasser:	Nielsen, Tobias Krogh, Petersen, Ida Birkjær, Xu, Lijuan, Barbuti, Maria Disen, Mebus, Viktor, Justh, Anni, Alqarzaee, Abdulelah Ahmed, Jacques, Nicolas, Oury, Cécile, Thomas, Vinai, Kjos, Morten, Henriksen, Camilla, Frees, Dorte
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Bacterial Proteins - genetics Bacterial Proteins - metabolism beta-Lactam Resistance - genetics beta-Lactams - pharmacology Gene Expression Regulation, Bacterial Genetics and Molecular Biology Mechanisms of Resistance Methicillin-Resistant Staphylococcus aureus - drug effects Methicillin-Resistant Staphylococcus aureus - genetics Microbial Sensitivity Tests Penicillin-Binding Proteins - genetics Penicillin-Binding Proteins - metabolism
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