Insights into the activity of cefiderocol against PER-2 producing Enterobacterales

The PER-2 β-lactamase is a unique class A enzyme conferring broad spectrum cephalosporin resistance. In this study, we explored the stability of cefiderocol (FDC) against PER-2 β-lactamase to gain insights into structure activity relationships (SAR) of this synthetic siderophore-conjugated antibioti...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2024-06, Vol.68 (6), p.e0172023
Hauptverfasser:	Ruggiero, Melina, Briceño Muñoz, Ivan, Gutkind, Gabriel, Hujer, Andrea M, Bonomo, Robert A, Power, Pablo
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antimicrobial Chemotherapy beta-Lactamases - genetics beta-Lactamases - metabolism Catalytic Domain Cefiderocol Cephalosporins - pharmacology Enterobacteriaceae - drug effects Enterobacteriaceae - genetics Mechanisms of Resistance Microbial Sensitivity Tests Structure-Activity Relationship
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