Pulsed DPOAEs in serial measurements: Combined analysis paradigm of simultaneously occurring changes in hearing thresholds and DPOAEs

Background To date, there is no consensus on how to standardize the assessment of ototoxicity in serial measurements. For the diagnosis of damage to the cochlear amplifier, measurement methods are required that have the highest possible test-retest reliability and validity for detecting persistent d...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:HNO 2024-12, Vol.72 (Suppl 2), p.101-110
Hauptverfasser: Bader, Katharina, Zelle, Dennis, Gummer, Anthony W., Dalhoff, Ernst
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 110
container_issue Suppl 2
container_start_page 101
container_title HNO
container_volume 72
creator Bader, Katharina
Zelle, Dennis
Gummer, Anthony W.
Dalhoff, Ernst
description Background To date, there is no consensus on how to standardize the assessment of ototoxicity in serial measurements. For the diagnosis of damage to the cochlear amplifier, measurement methods are required that have the highest possible test-retest reliability and validity for detecting persistent damage. Estimated distortion-product thresholds ( L EDPT ) based on short-pulse distortion-product otoacoustic emission (DPOAE) level maps use individually optimal DPOAE stimulus levels and allow reliable quantitative estimation of cochlea-related hearing loss. Materials and methods Hearing thresholds were estimated objectively using L EDPT and subjectively using modified Békésy tracking audiometry ( L TA ). Recordings were performed seven times within three months at 14 frequencies ( f 2  = 1–14 kHz) in 20 ears (PTA 4 (0.5–4   kHz)
doi_str_mv 10.1007/s00106-024-01478-z
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11618175</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3075377948</sourcerecordid><originalsourceid>FETCH-LOGICAL-c284t-815c6020b081b0fde634becd7846274132770856d2db36664a436087d367b1583</originalsourceid><addsrcrecordid>eNp9kDtPAzEQhC0EIiHwByhQCgoaw_rtq1AUwkNCSgqoLd-dEy66R7BzSOTX43AhgoZqtZrZmdWH0DmBawKgbgIAAYmBcgyEK403B6hPOGMYuNCHqB91hSVJaA-dhLCMq0goO0Y9phOhldB9dDlry-Dy4d1sOpqEYVEPg_OFLYeVs6H1rnL1Opyio7mNtrPdHKDX-8nL-BE_Tx-exqNnnFHN11gTkUmgkIImKcxzJxlPXZYrzSVVnDCqFGghc5qnTErJLWcStMqZVCkRmg3QbZe7atPK5Vns9rY0K19U1n-axhbmr1IXb2bRfBhCJNFEiZhwtUvwzXvrwtpURchcWdraNW0wDKJJqYRvy2hnzXwTgnfzfQ8Bs-VrOr4m8jXffM0mHl38_nB_8gM0GlhnCFGqF86bZdP6OlL7L_YLxjGEbg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3075377948</pqid></control><display><type>article</type><title>Pulsed DPOAEs in serial measurements: Combined analysis paradigm of simultaneously occurring changes in hearing thresholds and DPOAEs</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Bader, Katharina ; Zelle, Dennis ; Gummer, Anthony W. ; Dalhoff, Ernst</creator><creatorcontrib>Bader, Katharina ; Zelle, Dennis ; Gummer, Anthony W. ; Dalhoff, Ernst</creatorcontrib><description>Background To date, there is no consensus on how to standardize the assessment of ototoxicity in serial measurements. For the diagnosis of damage to the cochlear amplifier, measurement methods are required that have the highest possible test-retest reliability and validity for detecting persistent damage. Estimated distortion-product thresholds ( L EDPT ) based on short-pulse distortion-product otoacoustic emission (DPOAE) level maps use individually optimal DPOAE stimulus levels and allow reliable quantitative estimation of cochlea-related hearing loss. Materials and methods Hearing thresholds were estimated objectively using L EDPT and subjectively using modified Békésy tracking audiometry ( L TA ). Recordings were performed seven times within three months at 14 frequencies ( f 2  = 1–14 kHz) in 20 ears (PTA 4 (0.5–4   kHz) &lt; 20 dB HL). Reconstruction of the DPOAE growth behavior as a function of the stimulus levels L 1 , L 2 was performed on the basis of 21 DPOAE amplitudes. A numerical fit of a nonlinear mathematical function to the three-dimensional DPOAE growth function yielded L EDPT for each stimulus frequency. For the combined analysis, probability distributions of hearing thresholds ( L TA , L EDPT ), DPOAE levels ( L DP ), and combinations thereof were determined. Results L TA and L EDPT each exhibited a test-retest reliability with a median of absolute differences (AD) of 3.2 dB and 3.3 dB, respectively. Combining L EDPT , L DP , and L TA into a single parameter yielded a significantly smaller median AD of 2.0 dB. Conclusion It is expected that an analysis paradigm based on a combination of L EDPT , suprathreshold L DP , and fine-structure-reduced L TA would achieve higher test performance (sensitivity and specificity), allowing reliable detection of pathological or regenerative changes in the outer hair cells.</description><identifier>ISSN: 0017-6192</identifier><identifier>ISSN: 1433-0458</identifier><identifier>EISSN: 1433-0458</identifier><identifier>DOI: 10.1007/s00106-024-01478-z</identifier><identifier>PMID: 38958758</identifier><language>eng</language><publisher>Heidelberg: Springer Medizin</publisher><subject>Adult ; Aged ; Allergology ; Auditory Threshold - physiology ; Female ; Head and Neck Surgery ; Humans ; Male ; Medicine ; Medicine &amp; Public Health ; Middle Aged ; Original ; Original Articles ; Otoacoustic Emissions, Spontaneous - physiology ; Otorhinolaryngology ; Plastic Surgery ; Reproducibility of Results ; Sensitivity and Specificity ; Young Adult</subject><ispartof>HNO, 2024-12, Vol.72 (Suppl 2), p.101-110</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c284t-815c6020b081b0fde634becd7846274132770856d2db36664a436087d367b1583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00106-024-01478-z$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00106-024-01478-z$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38958758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bader, Katharina</creatorcontrib><creatorcontrib>Zelle, Dennis</creatorcontrib><creatorcontrib>Gummer, Anthony W.</creatorcontrib><creatorcontrib>Dalhoff, Ernst</creatorcontrib><title>Pulsed DPOAEs in serial measurements: Combined analysis paradigm of simultaneously occurring changes in hearing thresholds and DPOAEs</title><title>HNO</title><addtitle>HNO</addtitle><addtitle>HNO</addtitle><description>Background To date, there is no consensus on how to standardize the assessment of ototoxicity in serial measurements. For the diagnosis of damage to the cochlear amplifier, measurement methods are required that have the highest possible test-retest reliability and validity for detecting persistent damage. Estimated distortion-product thresholds ( L EDPT ) based on short-pulse distortion-product otoacoustic emission (DPOAE) level maps use individually optimal DPOAE stimulus levels and allow reliable quantitative estimation of cochlea-related hearing loss. Materials and methods Hearing thresholds were estimated objectively using L EDPT and subjectively using modified Békésy tracking audiometry ( L TA ). Recordings were performed seven times within three months at 14 frequencies ( f 2  = 1–14 kHz) in 20 ears (PTA 4 (0.5–4   kHz) &lt; 20 dB HL). Reconstruction of the DPOAE growth behavior as a function of the stimulus levels L 1 , L 2 was performed on the basis of 21 DPOAE amplitudes. A numerical fit of a nonlinear mathematical function to the three-dimensional DPOAE growth function yielded L EDPT for each stimulus frequency. For the combined analysis, probability distributions of hearing thresholds ( L TA , L EDPT ), DPOAE levels ( L DP ), and combinations thereof were determined. Results L TA and L EDPT each exhibited a test-retest reliability with a median of absolute differences (AD) of 3.2 dB and 3.3 dB, respectively. Combining L EDPT , L DP , and L TA into a single parameter yielded a significantly smaller median AD of 2.0 dB. Conclusion It is expected that an analysis paradigm based on a combination of L EDPT , suprathreshold L DP , and fine-structure-reduced L TA would achieve higher test performance (sensitivity and specificity), allowing reliable detection of pathological or regenerative changes in the outer hair cells.</description><subject>Adult</subject><subject>Aged</subject><subject>Allergology</subject><subject>Auditory Threshold - physiology</subject><subject>Female</subject><subject>Head and Neck Surgery</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Original Articles</subject><subject>Otoacoustic Emissions, Spontaneous - physiology</subject><subject>Otorhinolaryngology</subject><subject>Plastic Surgery</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Young Adult</subject><issn>0017-6192</issn><issn>1433-0458</issn><issn>1433-0458</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kDtPAzEQhC0EIiHwByhQCgoaw_rtq1AUwkNCSgqoLd-dEy66R7BzSOTX43AhgoZqtZrZmdWH0DmBawKgbgIAAYmBcgyEK403B6hPOGMYuNCHqB91hSVJaA-dhLCMq0goO0Y9phOhldB9dDlry-Dy4d1sOpqEYVEPg_OFLYeVs6H1rnL1Opyio7mNtrPdHKDX-8nL-BE_Tx-exqNnnFHN11gTkUmgkIImKcxzJxlPXZYrzSVVnDCqFGghc5qnTErJLWcStMqZVCkRmg3QbZe7atPK5Vns9rY0K19U1n-axhbmr1IXb2bRfBhCJNFEiZhwtUvwzXvrwtpURchcWdraNW0wDKJJqYRvy2hnzXwTgnfzfQ8Bs-VrOr4m8jXffM0mHl38_nB_8gM0GlhnCFGqF86bZdP6OlL7L_YLxjGEbg</recordid><startdate>20241201</startdate><enddate>20241201</enddate><creator>Bader, Katharina</creator><creator>Zelle, Dennis</creator><creator>Gummer, Anthony W.</creator><creator>Dalhoff, Ernst</creator><general>Springer Medizin</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20241201</creationdate><title>Pulsed DPOAEs in serial measurements</title><author>Bader, Katharina ; Zelle, Dennis ; Gummer, Anthony W. ; Dalhoff, Ernst</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c284t-815c6020b081b0fde634becd7846274132770856d2db36664a436087d367b1583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Allergology</topic><topic>Auditory Threshold - physiology</topic><topic>Female</topic><topic>Head and Neck Surgery</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Original Articles</topic><topic>Otoacoustic Emissions, Spontaneous - physiology</topic><topic>Otorhinolaryngology</topic><topic>Plastic Surgery</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bader, Katharina</creatorcontrib><creatorcontrib>Zelle, Dennis</creatorcontrib><creatorcontrib>Gummer, Anthony W.</creatorcontrib><creatorcontrib>Dalhoff, Ernst</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>HNO</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bader, Katharina</au><au>Zelle, Dennis</au><au>Gummer, Anthony W.</au><au>Dalhoff, Ernst</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulsed DPOAEs in serial measurements: Combined analysis paradigm of simultaneously occurring changes in hearing thresholds and DPOAEs</atitle><jtitle>HNO</jtitle><stitle>HNO</stitle><addtitle>HNO</addtitle><date>2024-12-01</date><risdate>2024</risdate><volume>72</volume><issue>Suppl 2</issue><spage>101</spage><epage>110</epage><pages>101-110</pages><issn>0017-6192</issn><issn>1433-0458</issn><eissn>1433-0458</eissn><abstract>Background To date, there is no consensus on how to standardize the assessment of ototoxicity in serial measurements. For the diagnosis of damage to the cochlear amplifier, measurement methods are required that have the highest possible test-retest reliability and validity for detecting persistent damage. Estimated distortion-product thresholds ( L EDPT ) based on short-pulse distortion-product otoacoustic emission (DPOAE) level maps use individually optimal DPOAE stimulus levels and allow reliable quantitative estimation of cochlea-related hearing loss. Materials and methods Hearing thresholds were estimated objectively using L EDPT and subjectively using modified Békésy tracking audiometry ( L TA ). Recordings were performed seven times within three months at 14 frequencies ( f 2  = 1–14 kHz) in 20 ears (PTA 4 (0.5–4   kHz) &lt; 20 dB HL). Reconstruction of the DPOAE growth behavior as a function of the stimulus levels L 1 , L 2 was performed on the basis of 21 DPOAE amplitudes. A numerical fit of a nonlinear mathematical function to the three-dimensional DPOAE growth function yielded L EDPT for each stimulus frequency. For the combined analysis, probability distributions of hearing thresholds ( L TA , L EDPT ), DPOAE levels ( L DP ), and combinations thereof were determined. Results L TA and L EDPT each exhibited a test-retest reliability with a median of absolute differences (AD) of 3.2 dB and 3.3 dB, respectively. Combining L EDPT , L DP , and L TA into a single parameter yielded a significantly smaller median AD of 2.0 dB. Conclusion It is expected that an analysis paradigm based on a combination of L EDPT , suprathreshold L DP , and fine-structure-reduced L TA would achieve higher test performance (sensitivity and specificity), allowing reliable detection of pathological or regenerative changes in the outer hair cells.</abstract><cop>Heidelberg</cop><pub>Springer Medizin</pub><pmid>38958758</pmid><doi>10.1007/s00106-024-01478-z</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0017-6192
ispartof HNO, 2024-12, Vol.72 (Suppl 2), p.101-110
issn 0017-6192
1433-0458
1433-0458
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11618175
source MEDLINE; Springer Nature - Complete Springer Journals
subjects Adult
Aged
Allergology
Auditory Threshold - physiology
Female
Head and Neck Surgery
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Original
Original Articles
Otoacoustic Emissions, Spontaneous - physiology
Otorhinolaryngology
Plastic Surgery
Reproducibility of Results
Sensitivity and Specificity
Young Adult
title Pulsed DPOAEs in serial measurements: Combined analysis paradigm of simultaneously occurring changes in hearing thresholds and DPOAEs
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T17%3A29%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pulsed%20DPOAEs%20in%20serial%20measurements:%20Combined%20analysis%20paradigm%20of%20simultaneously%20occurring%20changes%20in%20hearing%20thresholds%20and%20DPOAEs&rft.jtitle=HNO&rft.au=Bader,%20Katharina&rft.date=2024-12-01&rft.volume=72&rft.issue=Suppl%202&rft.spage=101&rft.epage=110&rft.pages=101-110&rft.issn=0017-6192&rft.eissn=1433-0458&rft_id=info:doi/10.1007/s00106-024-01478-z&rft_dat=%3Cproquest_pubme%3E3075377948%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3075377948&rft_id=info:pmid/38958758&rfr_iscdi=true