Pulsed DPOAEs in serial measurements: Combined analysis paradigm of simultaneously occurring changes in hearing thresholds and DPOAEs
Background To date, there is no consensus on how to standardize the assessment of ototoxicity in serial measurements. For the diagnosis of damage to the cochlear amplifier, measurement methods are required that have the highest possible test-retest reliability and validity for detecting persistent d...
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creator | Bader, Katharina Zelle, Dennis Gummer, Anthony W. Dalhoff, Ernst |
description | Background
To date, there is no consensus on how to standardize the assessment of ototoxicity in serial measurements. For the diagnosis of damage to the cochlear amplifier, measurement methods are required that have the highest possible test-retest reliability and validity for detecting persistent damage. Estimated distortion-product thresholds (
L
EDPT
) based on short-pulse distortion-product otoacoustic emission (DPOAE) level maps use individually optimal DPOAE stimulus levels and allow reliable quantitative estimation of cochlea-related hearing loss.
Materials and methods
Hearing thresholds were estimated objectively using
L
EDPT
and subjectively using modified Békésy tracking audiometry (
L
TA
). Recordings were performed seven times within three months at 14 frequencies (
f
2
= 1–14 kHz) in 20 ears (PTA
4
(0.5–4
kHz) |
doi_str_mv | 10.1007/s00106-024-01478-z |
format | Article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11618175</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3075377948</sourcerecordid><originalsourceid>FETCH-LOGICAL-c284t-815c6020b081b0fde634becd7846274132770856d2db36664a436087d367b1583</originalsourceid><addsrcrecordid>eNp9kDtPAzEQhC0EIiHwByhQCgoaw_rtq1AUwkNCSgqoLd-dEy66R7BzSOTX43AhgoZqtZrZmdWH0DmBawKgbgIAAYmBcgyEK403B6hPOGMYuNCHqB91hSVJaA-dhLCMq0goO0Y9phOhldB9dDlry-Dy4d1sOpqEYVEPg_OFLYeVs6H1rnL1Opyio7mNtrPdHKDX-8nL-BE_Tx-exqNnnFHN11gTkUmgkIImKcxzJxlPXZYrzSVVnDCqFGghc5qnTErJLWcStMqZVCkRmg3QbZe7atPK5Vns9rY0K19U1n-axhbmr1IXb2bRfBhCJNFEiZhwtUvwzXvrwtpURchcWdraNW0wDKJJqYRvy2hnzXwTgnfzfQ8Bs-VrOr4m8jXffM0mHl38_nB_8gM0GlhnCFGqF86bZdP6OlL7L_YLxjGEbg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3075377948</pqid></control><display><type>article</type><title>Pulsed DPOAEs in serial measurements: Combined analysis paradigm of simultaneously occurring changes in hearing thresholds and DPOAEs</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Bader, Katharina ; Zelle, Dennis ; Gummer, Anthony W. ; Dalhoff, Ernst</creator><creatorcontrib>Bader, Katharina ; Zelle, Dennis ; Gummer, Anthony W. ; Dalhoff, Ernst</creatorcontrib><description>Background
To date, there is no consensus on how to standardize the assessment of ototoxicity in serial measurements. For the diagnosis of damage to the cochlear amplifier, measurement methods are required that have the highest possible test-retest reliability and validity for detecting persistent damage. Estimated distortion-product thresholds (
L
EDPT
) based on short-pulse distortion-product otoacoustic emission (DPOAE) level maps use individually optimal DPOAE stimulus levels and allow reliable quantitative estimation of cochlea-related hearing loss.
Materials and methods
Hearing thresholds were estimated objectively using
L
EDPT
and subjectively using modified Békésy tracking audiometry (
L
TA
). Recordings were performed seven times within three months at 14 frequencies (
f
2
= 1–14 kHz) in 20 ears (PTA
4
(0.5–4
kHz)
< 20 dB HL). Reconstruction of the DPOAE growth behavior as a function of the stimulus levels
L
1
,
L
2
was performed on the basis of 21 DPOAE amplitudes. A numerical fit of a nonlinear mathematical function to the three-dimensional DPOAE growth function yielded
L
EDPT
for each stimulus frequency. For the combined analysis, probability distributions of hearing thresholds (
L
TA
,
L
EDPT
), DPOAE levels (
L
DP
), and combinations thereof were determined.
Results
L
TA
and
L
EDPT
each exhibited a test-retest reliability with a median of absolute differences (AD) of 3.2 dB and 3.3 dB, respectively. Combining
L
EDPT
,
L
DP
, and
L
TA
into a single parameter yielded a significantly smaller median AD of 2.0 dB.
Conclusion
It is expected that an analysis paradigm based on a combination of
L
EDPT
, suprathreshold
L
DP
, and fine-structure-reduced
L
TA
would achieve higher test performance (sensitivity and specificity), allowing reliable detection of pathological or regenerative changes in the outer hair cells.</description><identifier>ISSN: 0017-6192</identifier><identifier>ISSN: 1433-0458</identifier><identifier>EISSN: 1433-0458</identifier><identifier>DOI: 10.1007/s00106-024-01478-z</identifier><identifier>PMID: 38958758</identifier><language>eng</language><publisher>Heidelberg: Springer Medizin</publisher><subject>Adult ; Aged ; Allergology ; Auditory Threshold - physiology ; Female ; Head and Neck Surgery ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Original ; Original Articles ; Otoacoustic Emissions, Spontaneous - physiology ; Otorhinolaryngology ; Plastic Surgery ; Reproducibility of Results ; Sensitivity and Specificity ; Young Adult</subject><ispartof>HNO, 2024-12, Vol.72 (Suppl 2), p.101-110</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c284t-815c6020b081b0fde634becd7846274132770856d2db36664a436087d367b1583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00106-024-01478-z$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00106-024-01478-z$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38958758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bader, Katharina</creatorcontrib><creatorcontrib>Zelle, Dennis</creatorcontrib><creatorcontrib>Gummer, Anthony W.</creatorcontrib><creatorcontrib>Dalhoff, Ernst</creatorcontrib><title>Pulsed DPOAEs in serial measurements: Combined analysis paradigm of simultaneously occurring changes in hearing thresholds and DPOAEs</title><title>HNO</title><addtitle>HNO</addtitle><addtitle>HNO</addtitle><description>Background
To date, there is no consensus on how to standardize the assessment of ototoxicity in serial measurements. For the diagnosis of damage to the cochlear amplifier, measurement methods are required that have the highest possible test-retest reliability and validity for detecting persistent damage. Estimated distortion-product thresholds (
L
EDPT
) based on short-pulse distortion-product otoacoustic emission (DPOAE) level maps use individually optimal DPOAE stimulus levels and allow reliable quantitative estimation of cochlea-related hearing loss.
Materials and methods
Hearing thresholds were estimated objectively using
L
EDPT
and subjectively using modified Békésy tracking audiometry (
L
TA
). Recordings were performed seven times within three months at 14 frequencies (
f
2
= 1–14 kHz) in 20 ears (PTA
4
(0.5–4
kHz)
< 20 dB HL). Reconstruction of the DPOAE growth behavior as a function of the stimulus levels
L
1
,
L
2
was performed on the basis of 21 DPOAE amplitudes. A numerical fit of a nonlinear mathematical function to the three-dimensional DPOAE growth function yielded
L
EDPT
for each stimulus frequency. For the combined analysis, probability distributions of hearing thresholds (
L
TA
,
L
EDPT
), DPOAE levels (
L
DP
), and combinations thereof were determined.
Results
L
TA
and
L
EDPT
each exhibited a test-retest reliability with a median of absolute differences (AD) of 3.2 dB and 3.3 dB, respectively. Combining
L
EDPT
,
L
DP
, and
L
TA
into a single parameter yielded a significantly smaller median AD of 2.0 dB.
Conclusion
It is expected that an analysis paradigm based on a combination of
L
EDPT
, suprathreshold
L
DP
, and fine-structure-reduced
L
TA
would achieve higher test performance (sensitivity and specificity), allowing reliable detection of pathological or regenerative changes in the outer hair cells.</description><subject>Adult</subject><subject>Aged</subject><subject>Allergology</subject><subject>Auditory Threshold - physiology</subject><subject>Female</subject><subject>Head and Neck Surgery</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Original Articles</subject><subject>Otoacoustic Emissions, Spontaneous - physiology</subject><subject>Otorhinolaryngology</subject><subject>Plastic Surgery</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Young Adult</subject><issn>0017-6192</issn><issn>1433-0458</issn><issn>1433-0458</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kDtPAzEQhC0EIiHwByhQCgoaw_rtq1AUwkNCSgqoLd-dEy66R7BzSOTX43AhgoZqtZrZmdWH0DmBawKgbgIAAYmBcgyEK403B6hPOGMYuNCHqB91hSVJaA-dhLCMq0goO0Y9phOhldB9dDlry-Dy4d1sOpqEYVEPg_OFLYeVs6H1rnL1Opyio7mNtrPdHKDX-8nL-BE_Tx-exqNnnFHN11gTkUmgkIImKcxzJxlPXZYrzSVVnDCqFGghc5qnTErJLWcStMqZVCkRmg3QbZe7atPK5Vns9rY0K19U1n-axhbmr1IXb2bRfBhCJNFEiZhwtUvwzXvrwtpURchcWdraNW0wDKJJqYRvy2hnzXwTgnfzfQ8Bs-VrOr4m8jXffM0mHl38_nB_8gM0GlhnCFGqF86bZdP6OlL7L_YLxjGEbg</recordid><startdate>20241201</startdate><enddate>20241201</enddate><creator>Bader, Katharina</creator><creator>Zelle, Dennis</creator><creator>Gummer, Anthony W.</creator><creator>Dalhoff, Ernst</creator><general>Springer Medizin</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20241201</creationdate><title>Pulsed DPOAEs in serial measurements</title><author>Bader, Katharina ; Zelle, Dennis ; Gummer, Anthony W. ; Dalhoff, Ernst</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c284t-815c6020b081b0fde634becd7846274132770856d2db36664a436087d367b1583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Allergology</topic><topic>Auditory Threshold - physiology</topic><topic>Female</topic><topic>Head and Neck Surgery</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Original Articles</topic><topic>Otoacoustic Emissions, Spontaneous - physiology</topic><topic>Otorhinolaryngology</topic><topic>Plastic Surgery</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bader, Katharina</creatorcontrib><creatorcontrib>Zelle, Dennis</creatorcontrib><creatorcontrib>Gummer, Anthony W.</creatorcontrib><creatorcontrib>Dalhoff, Ernst</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>HNO</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bader, Katharina</au><au>Zelle, Dennis</au><au>Gummer, Anthony W.</au><au>Dalhoff, Ernst</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulsed DPOAEs in serial measurements: Combined analysis paradigm of simultaneously occurring changes in hearing thresholds and DPOAEs</atitle><jtitle>HNO</jtitle><stitle>HNO</stitle><addtitle>HNO</addtitle><date>2024-12-01</date><risdate>2024</risdate><volume>72</volume><issue>Suppl 2</issue><spage>101</spage><epage>110</epage><pages>101-110</pages><issn>0017-6192</issn><issn>1433-0458</issn><eissn>1433-0458</eissn><abstract>Background
To date, there is no consensus on how to standardize the assessment of ototoxicity in serial measurements. For the diagnosis of damage to the cochlear amplifier, measurement methods are required that have the highest possible test-retest reliability and validity for detecting persistent damage. Estimated distortion-product thresholds (
L
EDPT
) based on short-pulse distortion-product otoacoustic emission (DPOAE) level maps use individually optimal DPOAE stimulus levels and allow reliable quantitative estimation of cochlea-related hearing loss.
Materials and methods
Hearing thresholds were estimated objectively using
L
EDPT
and subjectively using modified Békésy tracking audiometry (
L
TA
). Recordings were performed seven times within three months at 14 frequencies (
f
2
= 1–14 kHz) in 20 ears (PTA
4
(0.5–4
kHz)
< 20 dB HL). Reconstruction of the DPOAE growth behavior as a function of the stimulus levels
L
1
,
L
2
was performed on the basis of 21 DPOAE amplitudes. A numerical fit of a nonlinear mathematical function to the three-dimensional DPOAE growth function yielded
L
EDPT
for each stimulus frequency. For the combined analysis, probability distributions of hearing thresholds (
L
TA
,
L
EDPT
), DPOAE levels (
L
DP
), and combinations thereof were determined.
Results
L
TA
and
L
EDPT
each exhibited a test-retest reliability with a median of absolute differences (AD) of 3.2 dB and 3.3 dB, respectively. Combining
L
EDPT
,
L
DP
, and
L
TA
into a single parameter yielded a significantly smaller median AD of 2.0 dB.
Conclusion
It is expected that an analysis paradigm based on a combination of
L
EDPT
, suprathreshold
L
DP
, and fine-structure-reduced
L
TA
would achieve higher test performance (sensitivity and specificity), allowing reliable detection of pathological or regenerative changes in the outer hair cells.</abstract><cop>Heidelberg</cop><pub>Springer Medizin</pub><pmid>38958758</pmid><doi>10.1007/s00106-024-01478-z</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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source | MEDLINE; Springer Nature - Complete Springer Journals |
subjects | Adult Aged Allergology Auditory Threshold - physiology Female Head and Neck Surgery Humans Male Medicine Medicine & Public Health Middle Aged Original Original Articles Otoacoustic Emissions, Spontaneous - physiology Otorhinolaryngology Plastic Surgery Reproducibility of Results Sensitivity and Specificity Young Adult |
title | Pulsed DPOAEs in serial measurements: Combined analysis paradigm of simultaneously occurring changes in hearing thresholds and DPOAEs |
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