Renal Angptl4 is a key fibrogenic molecule in progressive diabetic kidney disease

Angiopoietin-like 4 (ANGPTL4), a key protein involved in lipoprotein metabolism, has diverse effects. There is an association between Angptl4 and diabetic kidney disease; however, this association has not been well investigated. We show that both podocyte- and tubule-specific ANGPTL4 are crucial fib...

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Veröffentlicht in:	Science advances 2024-12, Vol.10 (49), p.eadn6068
Hauptverfasser:	Srivastava, Swayam Prakash, Zhou, Han, Shenoi, Rachel, Morris, Myshal, Lainez-Mas, Begoña, Goedeke, Leigh, Rajendran, Barani Kumar, Setia, Ocean, Aryal, Binod, Kanasaki, Keizo, Koya, Daisuke, Inoki, Ken, Dardik, Alan, Bell, 3rd, Thomas, Fernández-Hernando, Carlos, Shulman, Gerald I, Goodwin, Julie E
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiopoietin-Like Protein 4 - genetics Angiopoietin-Like Protein 4 - metabolism Animals Biomedicine and Life Sciences Diabetes Mellitus, Experimental - metabolism Diabetic Nephropathies - genetics Diabetic Nephropathies - metabolism Diabetic Nephropathies - pathology Disease Models, Animal Epithelial-Mesenchymal Transition Fibrosis Humans Integrin beta1 - genetics Integrin beta1 - metabolism Kidney - metabolism Kidney - pathology Life Sciences Mice Podocytes - metabolism Podocytes - pathology SciAdv r-articles
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