Evidence for association-activation effects in reactions of papain from studies on its reactivity towards isomeric two-protonic-state reactivity probes

4-(N-Aminoethyl 4-pyridyl disulphide)-7-nitrobenzo-2-oxa-1,3-diazole was synthesized and evaluted as a two-protonic-state reactivity probe by kinetic study of its reactions with papain (EC 3.4.22.2) and with benzimidazol-2-ylmethanethiol. Evidence is presented to suggest that: (i) both this probe mo...

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Veröffentlicht in:	Biochemical journal 1979-11, Vol.183 (2), p.369-373
Hauptverfasser:	Brocklehurst, K, Herbert, J A, Norris, R, Suschitzky, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Chemical Phenomena Chemistry Enzyme Activation Isomerism Kinetics Models, Chemical Oxadiazoles - chemical synthesis Papain
Online-Zugang:	Volltext
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