A hybrid repair strategy for full‐thickness cartilage defects: Long‐term experimental study in eight horses
The objective of this study was to evaluate a non‐resorbable implant for the focal repair of chondral defects in eight adult horses with 12‐month follow‐up. The bi‐layered construct composed of a polycarbonate‐urethane‐urea biomaterial which was printed in 3D fashion onto a bone anchor was implanted...
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| Veröffentlicht in: | Journal of orthopaedic research 2025-01, Vol.43 (1), p.59-69 |
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| creator | Fugazzola, Maria C. De Ruijter, Mylène Veraa, Stefanie Plomp, Saskia Buul, Ward Hermsen, Gied Weeren, René |
| description | The objective of this study was to evaluate a non‐resorbable implant for the focal repair of chondral defects in eight adult horses with 12‐month follow‐up. The bi‐layered construct composed of a polycarbonate‐urethane‐urea biomaterial which was printed in 3D fashion onto a bone anchor was implanted into surgically created osteochondral defects into the femoropatellar joints of eight horses. The analysis of post‐mortem outcomes were compared to defects treated with microfracture in the same animal on the contralateral femoropatellar jointfemoropatellar joint. The overall macroscopic scoring after 12 months yielded higher scores in the OCI‐treated stifles compared to MF treatment (p = 0.09) with better quality and filling of the defect. Histology revealed good anchorage of repair tissue growing into the 3D structure of the implant and histopathology scoring for adjacent native cartilage showed no difference between groups. MRI and micro‐CT showed overall less sclerotic reactions in the surrounding bone in the implant group and no foreign body reaction was detected. Biomechanical analysis of the repair tissue revealed a significantly higher peak modulus (p |
| doi_str_mv | 10.1002/jor.25972 |
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The bi‐layered construct composed of a polycarbonate‐urethane‐urea biomaterial which was printed in 3D fashion onto a bone anchor was implanted into surgically created osteochondral defects into the femoropatellar joints of eight horses. The analysis of post‐mortem outcomes were compared to defects treated with microfracture in the same animal on the contralateral femoropatellar jointfemoropatellar joint. The overall macroscopic scoring after 12 months yielded higher scores in the OCI‐treated stifles compared to MF treatment (p = 0.09) with better quality and filling of the defect. Histology revealed good anchorage of repair tissue growing into the 3D structure of the implant and histopathology scoring for adjacent native cartilage showed no difference between groups. MRI and micro‐CT showed overall less sclerotic reactions in the surrounding bone in the implant group and no foreign body reaction was detected. Biomechanical analysis of the repair tissue revealed a significantly higher peak modulus (p < 0.05) in the implant group (0.74 ± 0.45) compared to the microfracture control group (0.15 ± 0.11). Dynamic loading yielded higher values for the repair tissue overgrowing the implant group (0.23 ± 0.17) compared to the microfracture control (0.06 ± 0.06) (p < 0.05). The bi‐layered osteochondral implant provided a safe implant for focal repair of full‐thickness osteochondral defects, as no adverse reaction was seen within the joints and the level of degeneration of adjacent cartilage to the repair site was not different compared to that seen in defects treated with microfracture after 12 months.</description><identifier>ISSN: 0736-0266</identifier><identifier>ISSN: 1554-527X</identifier><identifier>EISSN: 1554-527X</identifier><identifier>DOI: 10.1002/jor.25972</identifier><identifier>PMID: 39292194</identifier><language>eng</language><publisher>United States: John Wiley and Sons Inc</publisher><subject>Animals ; biomechanics ; cartilage ; Cartilage Diseases - surgery ; Cartilage, Articular - injuries ; Cartilage, Articular - pathology ; Cartilage, Articular - surgery ; Female ; fibrocartilage ; Horses ; Male ; osteoarthritis ; X-Ray Microtomography</subject><ispartof>Journal of orthopaedic research, 2025-01, Vol.43 (1), p.59-69</ispartof><rights>2024 The Author(s). published by Wiley Periodicals LLC on behalf of Orthopaedic Research Society.</rights><rights>2024 The Author(s). Journal of Orthopaedic Research® published by Wiley Periodicals LLC on behalf of Orthopaedic Research Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3062-1444579ee22d31793d3574c002819a77574c519002ce40d2678e1a32f18f408e3</cites><orcidid>0000-0002-4152-0948</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjor.25972$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjor.25972$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39292194$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fugazzola, Maria C.</creatorcontrib><creatorcontrib>De Ruijter, Mylène</creatorcontrib><creatorcontrib>Veraa, Stefanie</creatorcontrib><creatorcontrib>Plomp, Saskia</creatorcontrib><creatorcontrib>Buul, Ward</creatorcontrib><creatorcontrib>Hermsen, Gied</creatorcontrib><creatorcontrib>Weeren, René</creatorcontrib><title>A hybrid repair strategy for full‐thickness cartilage defects: Long‐term experimental study in eight horses</title><title>Journal of orthopaedic research</title><addtitle>J Orthop Res</addtitle><description>The objective of this study was to evaluate a non‐resorbable implant for the focal repair of chondral defects in eight adult horses with 12‐month follow‐up. The bi‐layered construct composed of a polycarbonate‐urethane‐urea biomaterial which was printed in 3D fashion onto a bone anchor was implanted into surgically created osteochondral defects into the femoropatellar joints of eight horses. The analysis of post‐mortem outcomes were compared to defects treated with microfracture in the same animal on the contralateral femoropatellar jointfemoropatellar joint. The overall macroscopic scoring after 12 months yielded higher scores in the OCI‐treated stifles compared to MF treatment (p = 0.09) with better quality and filling of the defect. Histology revealed good anchorage of repair tissue growing into the 3D structure of the implant and histopathology scoring for adjacent native cartilage showed no difference between groups. MRI and micro‐CT showed overall less sclerotic reactions in the surrounding bone in the implant group and no foreign body reaction was detected. Biomechanical analysis of the repair tissue revealed a significantly higher peak modulus (p < 0.05) in the implant group (0.74 ± 0.45) compared to the microfracture control group (0.15 ± 0.11). Dynamic loading yielded higher values for the repair tissue overgrowing the implant group (0.23 ± 0.17) compared to the microfracture control (0.06 ± 0.06) (p < 0.05). The bi‐layered osteochondral implant provided a safe implant for focal repair of full‐thickness osteochondral defects, as no adverse reaction was seen within the joints and the level of degeneration of adjacent cartilage to the repair site was not different compared to that seen in defects treated with microfracture after 12 months.</description><subject>Animals</subject><subject>biomechanics</subject><subject>cartilage</subject><subject>Cartilage Diseases - surgery</subject><subject>Cartilage, Articular - injuries</subject><subject>Cartilage, Articular - pathology</subject><subject>Cartilage, Articular - surgery</subject><subject>Female</subject><subject>fibrocartilage</subject><subject>Horses</subject><subject>Male</subject><subject>osteoarthritis</subject><subject>X-Ray Microtomography</subject><issn>0736-0266</issn><issn>1554-527X</issn><issn>1554-527X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp1kc1O3DAURq0KVKaUBS-AvIRFwH-JEzYIIVqKRkKqWomdZZybxOCJBztpyY5H4Bn7JHg6FJUFK-vKR8ff9YfQLiWHlBB2dOvDIcsryT6gGc1zkeVMXm-gGZG8yAgrii30KcZbQoikrPyItnjFKkYrMUP-FHfTTbA1DrDUNuA4BD1AO-HGB9yMzv15fBo6a-56iBEbHQbrdAu4hgbMEI_x3PftioGwwPCwhGAX0A_aJdNYT9j2GGzbDbjzIUL8jDYb7SLsvJzb6OeX8x9nF9n86uu3s9N5ZjgpWEaFELmsABirOZUVr3kuhUnLlrTSUq6GnFZpNiBIzQpZAtWcNbRsBCmBb6OTtXc53iygNilS0E4tUzodJuW1VW9vetup1v9SlBY0F0wmw_6LIfj7EeKgFjYacE734MeoOCWFKNJ_rtCDNWqCjzFA8_oOJWrVkEoNqb8NJXbv_2Cv5L9KEnC0Bn5bB9P7JnV59X2tfAaeIZ4L</recordid><startdate>202501</startdate><enddate>202501</enddate><creator>Fugazzola, Maria C.</creator><creator>De Ruijter, Mylène</creator><creator>Veraa, Stefanie</creator><creator>Plomp, Saskia</creator><creator>Buul, Ward</creator><creator>Hermsen, Gied</creator><creator>Weeren, René</creator><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4152-0948</orcidid></search><sort><creationdate>202501</creationdate><title>A hybrid repair strategy for full‐thickness cartilage defects: Long‐term experimental study in eight horses</title><author>Fugazzola, Maria C. ; De Ruijter, Mylène ; Veraa, Stefanie ; Plomp, Saskia ; Buul, Ward ; Hermsen, Gied ; Weeren, René</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3062-1444579ee22d31793d3574c002819a77574c519002ce40d2678e1a32f18f408e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Animals</topic><topic>biomechanics</topic><topic>cartilage</topic><topic>Cartilage Diseases - surgery</topic><topic>Cartilage, Articular - injuries</topic><topic>Cartilage, Articular - pathology</topic><topic>Cartilage, Articular - surgery</topic><topic>Female</topic><topic>fibrocartilage</topic><topic>Horses</topic><topic>Male</topic><topic>osteoarthritis</topic><topic>X-Ray Microtomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fugazzola, Maria C.</creatorcontrib><creatorcontrib>De Ruijter, Mylène</creatorcontrib><creatorcontrib>Veraa, Stefanie</creatorcontrib><creatorcontrib>Plomp, Saskia</creatorcontrib><creatorcontrib>Buul, Ward</creatorcontrib><creatorcontrib>Hermsen, Gied</creatorcontrib><creatorcontrib>Weeren, René</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of orthopaedic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fugazzola, Maria C.</au><au>De Ruijter, Mylène</au><au>Veraa, Stefanie</au><au>Plomp, Saskia</au><au>Buul, Ward</au><au>Hermsen, Gied</au><au>Weeren, René</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A hybrid repair strategy for full‐thickness cartilage defects: Long‐term experimental study in eight horses</atitle><jtitle>Journal of orthopaedic research</jtitle><addtitle>J Orthop Res</addtitle><date>2025-01</date><risdate>2025</risdate><volume>43</volume><issue>1</issue><spage>59</spage><epage>69</epage><pages>59-69</pages><issn>0736-0266</issn><issn>1554-527X</issn><eissn>1554-527X</eissn><abstract>The objective of this study was to evaluate a non‐resorbable implant for the focal repair of chondral defects in eight adult horses with 12‐month follow‐up. The bi‐layered construct composed of a polycarbonate‐urethane‐urea biomaterial which was printed in 3D fashion onto a bone anchor was implanted into surgically created osteochondral defects into the femoropatellar joints of eight horses. The analysis of post‐mortem outcomes were compared to defects treated with microfracture in the same animal on the contralateral femoropatellar jointfemoropatellar joint. The overall macroscopic scoring after 12 months yielded higher scores in the OCI‐treated stifles compared to MF treatment (p = 0.09) with better quality and filling of the defect. Histology revealed good anchorage of repair tissue growing into the 3D structure of the implant and histopathology scoring for adjacent native cartilage showed no difference between groups. MRI and micro‐CT showed overall less sclerotic reactions in the surrounding bone in the implant group and no foreign body reaction was detected. Biomechanical analysis of the repair tissue revealed a significantly higher peak modulus (p < 0.05) in the implant group (0.74 ± 0.45) compared to the microfracture control group (0.15 ± 0.11). Dynamic loading yielded higher values for the repair tissue overgrowing the implant group (0.23 ± 0.17) compared to the microfracture control (0.06 ± 0.06) (p < 0.05). The bi‐layered osteochondral implant provided a safe implant for focal repair of full‐thickness osteochondral defects, as no adverse reaction was seen within the joints and the level of degeneration of adjacent cartilage to the repair site was not different compared to that seen in defects treated with microfracture after 12 months.</abstract><cop>United States</cop><pub>John Wiley and Sons Inc</pub><pmid>39292194</pmid><doi>10.1002/jor.25972</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-4152-0948</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals biomechanics cartilage Cartilage Diseases - surgery Cartilage, Articular - injuries Cartilage, Articular - pathology Cartilage, Articular - surgery Female fibrocartilage Horses Male osteoarthritis X-Ray Microtomography |
| title | A hybrid repair strategy for full‐thickness cartilage defects: Long‐term experimental study in eight horses |
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