4‑(Pyrazolyl)benzenesulfonamide Ureas as Carbonic Anhydrases Inhibitors and Hypoxia-Mediated Chemo-Sensitizing Agents in Colorectal Cancer Cells

Hypoxia in tumors contributes to chemotherapy resistance, worsened by acidosis driven by carbonic anhydrases (hCA IX and XII). Targeting these enzymes can mitigate acidosis, thus enhancing tumor sensitivity to cytotoxic drugs. Herein, novel 4-(pyrazolyl)benzenesulfonamide ureas (SH7a–t) were develo...

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Veröffentlicht in:	Journal of medicinal chemistry 2024-11, Vol.67 (22), p.20438-20454
Hauptverfasser:	Eldehna, Wagdy M., Fares, Mohamed, Bonardi, Alessandro, Avgenikos, Moscos, Baselious, Fady, Schmidt, Matthias, Al-Warhi, Tarfah, Abdel-Aziz, Hatem A., Rennert, Robert, Peat, Thomas S., Supuran, Claudiu T., Wessjohann, Ludger A., Ibrahim, Hany S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Neoplasm Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Benzenesulfonamides Carbonic Anhydrase Inhibitors - chemical synthesis Carbonic Anhydrase Inhibitors - chemistry Carbonic Anhydrase Inhibitors - pharmacology Carbonic Anhydrase IX - antagonists & inhibitors Carbonic Anhydrase IX - metabolism Carbonic Anhydrases - metabolism Cell Line, Tumor Cell Proliferation - drug effects Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Drug Screening Assays, Antitumor Humans Pyrazoles - chemical synthesis Pyrazoles - chemistry Pyrazoles - pharmacology Structure-Activity Relationship Sulfonamides - chemical synthesis Sulfonamides - chemistry Sulfonamides - pharmacology Urea - analogs & derivatives Urea - chemistry Urea - pharmacology
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