Are congenital malformations associated with maternal sociodemographic and risk factors? A multicenter ultrasound-based study
Congenital malformations (CM) are structural defects of the human body that arise during development. They significantly impact neonatal outcomes such as morbidity and mortality, hence identification of risk factors and their reduction is vital to improve materno-fetal outcomes. In Karachi, Pakistan...
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Veröffentlicht in: | Pakistan journal of medical sciences 2024-12, Vol.40 (11), p.2538-2543 |
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description | Congenital malformations (CM) are structural defects of the human body that arise during development. They significantly impact neonatal outcomes such as morbidity and mortality, hence identification of risk factors and their reduction is vital to improve materno-fetal outcomes. In Karachi, Pakistan, there is insufficient data on the incidence of congenital malformations. Therefore, it is necessary to initiate a prospective case control study. The desired objective was to determine the association of congenital malformations with sociodemographic and maternal risk factors in different ethnicities.
This multi-center case control study spanned over a duration of six months (December 2022 - May 2023) and included women ranging from 18-45 years using purposive sampling technique. It was conducted at Jinnah Postgraduate Medical Center and Tanveer Ultrasound Clinic. Sample of 120 participants fulfilling the inclusion criteria were included in this study after purposive sampling. Sonoscape S22 ultrasound system and Toshiba Aplio 500 ultrasound system were used to detect congenital malformations.
Participants were divided into five groups based on ethnicity. Most of the congenital anomalies of the central nervous system were seen in Urdu-speaking group with a p-value = 0.016. An association between maternal age, education level, family income and medications with congenital malformations in fetuses was observed with p-values of 0.003, 0.000, 0.024 and 0.000 respectively.
It was evident that various maternal sociodemographic and risk factors play a significant role in the development of congenital anomalies. |
doi_str_mv | 10.12669/pjms.40.11.9792 |
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This multi-center case control study spanned over a duration of six months (December 2022 - May 2023) and included women ranging from 18-45 years using purposive sampling technique. It was conducted at Jinnah Postgraduate Medical Center and Tanveer Ultrasound Clinic. Sample of 120 participants fulfilling the inclusion criteria were included in this study after purposive sampling. Sonoscape S22 ultrasound system and Toshiba Aplio 500 ultrasound system were used to detect congenital malformations.
Participants were divided into five groups based on ethnicity. Most of the congenital anomalies of the central nervous system were seen in Urdu-speaking group with a p-value = 0.016. An association between maternal age, education level, family income and medications with congenital malformations in fetuses was observed with p-values of 0.003, 0.000, 0.024 and 0.000 respectively.
It was evident that various maternal sociodemographic and risk factors play a significant role in the development of congenital anomalies.</description><identifier>ISSN: 1682-024X</identifier><identifier>EISSN: 1681-715X</identifier><identifier>DOI: 10.12669/pjms.40.11.9792</identifier><identifier>PMID: 39634866</identifier><language>eng</language><publisher>Pakistan: Knowledge Bylanes</publisher><subject>Age groups ; Birth defects ; Congenital diseases ; Ethnicity ; Family income ; Fetuses ; Genetic disorders ; Health aspects ; Nervous system ; Original ; Pregnancy ; Regression analysis ; Risk factors ; Rubella ; Sociodemographics ; Ultrasonic imaging ; Vitamin B ; Womens health</subject><ispartof>Pakistan journal of medical sciences, 2024-12, Vol.40 (11), p.2538-2543</ispartof><rights>Copyright: © Pakistan Journal of Medical Sciences.</rights><rights>COPYRIGHT 2024 Knowledge Bylanes</rights><rights>(c)2024 Pakistan Journal of Medical Sciences</rights><rights>Copyright: © Pakistan Journal of Medical Sciences 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0001-7168-6589</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11613379/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11613379/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39634866$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Awan, Jawaria Aslam</creatorcontrib><creatorcontrib>Qamar, Aisha</creatorcontrib><creatorcontrib>Surti, Ambreen</creatorcontrib><creatorcontrib>Anwar, Eman</creatorcontrib><title>Are congenital malformations associated with maternal sociodemographic and risk factors? A multicenter ultrasound-based study</title><title>Pakistan journal of medical sciences</title><addtitle>Pak J Med Sci</addtitle><description>Congenital malformations (CM) are structural defects of the human body that arise during development. They significantly impact neonatal outcomes such as morbidity and mortality, hence identification of risk factors and their reduction is vital to improve materno-fetal outcomes. In Karachi, Pakistan, there is insufficient data on the incidence of congenital malformations. Therefore, it is necessary to initiate a prospective case control study. The desired objective was to determine the association of congenital malformations with sociodemographic and maternal risk factors in different ethnicities.
This multi-center case control study spanned over a duration of six months (December 2022 - May 2023) and included women ranging from 18-45 years using purposive sampling technique. It was conducted at Jinnah Postgraduate Medical Center and Tanveer Ultrasound Clinic. Sample of 120 participants fulfilling the inclusion criteria were included in this study after purposive sampling. Sonoscape S22 ultrasound system and Toshiba Aplio 500 ultrasound system were used to detect congenital malformations.
Participants were divided into five groups based on ethnicity. Most of the congenital anomalies of the central nervous system were seen in Urdu-speaking group with a p-value = 0.016. An association between maternal age, education level, family income and medications with congenital malformations in fetuses was observed with p-values of 0.003, 0.000, 0.024 and 0.000 respectively.
It was evident that various maternal sociodemographic and risk factors play a significant role in the development of congenital anomalies.</description><subject>Age groups</subject><subject>Birth defects</subject><subject>Congenital diseases</subject><subject>Ethnicity</subject><subject>Family income</subject><subject>Fetuses</subject><subject>Genetic disorders</subject><subject>Health aspects</subject><subject>Nervous system</subject><subject>Original</subject><subject>Pregnancy</subject><subject>Regression analysis</subject><subject>Risk factors</subject><subject>Rubella</subject><subject>Sociodemographics</subject><subject>Ultrasonic imaging</subject><subject>Vitamin B</subject><subject>Womens health</subject><issn>1682-024X</issn><issn>1681-715X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptUstq3DAUNaWhSZPuuyqCQnaeWg_L9ioMoS8IdJNAduJaj7GmtjSV5JQs8u-VJ2magaKF7uOcg3TuLYr3uFphwnn3abed4orlDK-6piOvihPMW1w2uL59vY9JWRF2e1y8jXFbVYyzmrwpjmnHKWs5Pyke1kEj6d1GO5tgRBOMxocJkvUuIojRSwtJK_TbpiF3kw4uw5ayV3rymwC7wUoETqFg409kQCYf4gVao2kek5XaZQ7KYYDoZ6fKHmLWi2lW92fFkYEx6ndP92lx8-Xz9eW38urH1--X66tSEsa7smUYVNM0dc8MVpxTTYipq75roe4VUKNBEt30VLFWcdJzbKSiDcWk0lzXPT0tLh51d3M_abW8KcAodsFOEO6FBysOO84OYuPvBMYcU9p0WeHjk0Lwv2Ydk9j6ebEiCooXLykn7T_UBkYtrDM-q8nJRinWLW5rQnm1aK3-g8onG2rzLLSxuX5AOH9BGDSMaYh-nPdDOgRWj0AZfIxBm-cv4krsN0YsGyNYzrBYNiZTPry05pnwd0XoH2ILv5w</recordid><startdate>20241231</startdate><enddate>20241231</enddate><creator>Awan, Jawaria Aslam</creator><creator>Qamar, Aisha</creator><creator>Surti, Ambreen</creator><creator>Anwar, Eman</creator><general>Knowledge Bylanes</general><general>AsiaNet Pakistan (Pvt) Ltd</general><general>Professional Medical Publications</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7168-6589</orcidid></search><sort><creationdate>20241231</creationdate><title>Are congenital malformations associated with maternal sociodemographic and risk factors? A multicenter ultrasound-based study</title><author>Awan, Jawaria Aslam ; Qamar, Aisha ; Surti, Ambreen ; Anwar, Eman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2469-841ad7775b4f1d663e22f50b98a5bda3feac2e7b3d48d62b61fcd373120e6e5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Age groups</topic><topic>Birth defects</topic><topic>Congenital diseases</topic><topic>Ethnicity</topic><topic>Family income</topic><topic>Fetuses</topic><topic>Genetic disorders</topic><topic>Health aspects</topic><topic>Nervous system</topic><topic>Original</topic><topic>Pregnancy</topic><topic>Regression analysis</topic><topic>Risk factors</topic><topic>Rubella</topic><topic>Sociodemographics</topic><topic>Ultrasonic imaging</topic><topic>Vitamin B</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Awan, Jawaria Aslam</creatorcontrib><creatorcontrib>Qamar, Aisha</creatorcontrib><creatorcontrib>Surti, Ambreen</creatorcontrib><creatorcontrib>Anwar, Eman</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pakistan journal of medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Awan, Jawaria Aslam</au><au>Qamar, Aisha</au><au>Surti, Ambreen</au><au>Anwar, Eman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Are congenital malformations associated with maternal sociodemographic and risk factors? A multicenter ultrasound-based study</atitle><jtitle>Pakistan journal of medical sciences</jtitle><addtitle>Pak J Med Sci</addtitle><date>2024-12-31</date><risdate>2024</risdate><volume>40</volume><issue>11</issue><spage>2538</spage><epage>2543</epage><pages>2538-2543</pages><issn>1682-024X</issn><eissn>1681-715X</eissn><abstract>Congenital malformations (CM) are structural defects of the human body that arise during development. They significantly impact neonatal outcomes such as morbidity and mortality, hence identification of risk factors and their reduction is vital to improve materno-fetal outcomes. In Karachi, Pakistan, there is insufficient data on the incidence of congenital malformations. Therefore, it is necessary to initiate a prospective case control study. The desired objective was to determine the association of congenital malformations with sociodemographic and maternal risk factors in different ethnicities.
This multi-center case control study spanned over a duration of six months (December 2022 - May 2023) and included women ranging from 18-45 years using purposive sampling technique. It was conducted at Jinnah Postgraduate Medical Center and Tanveer Ultrasound Clinic. Sample of 120 participants fulfilling the inclusion criteria were included in this study after purposive sampling. Sonoscape S22 ultrasound system and Toshiba Aplio 500 ultrasound system were used to detect congenital malformations.
Participants were divided into five groups based on ethnicity. Most of the congenital anomalies of the central nervous system were seen in Urdu-speaking group with a p-value = 0.016. An association between maternal age, education level, family income and medications with congenital malformations in fetuses was observed with p-values of 0.003, 0.000, 0.024 and 0.000 respectively.
It was evident that various maternal sociodemographic and risk factors play a significant role in the development of congenital anomalies.</abstract><cop>Pakistan</cop><pub>Knowledge Bylanes</pub><pmid>39634866</pmid><doi>10.12669/pjms.40.11.9792</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-7168-6589</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Age groups Birth defects Congenital diseases Ethnicity Family income Fetuses Genetic disorders Health aspects Nervous system Original Pregnancy Regression analysis Risk factors Rubella Sociodemographics Ultrasonic imaging Vitamin B Womens health |
title | Are congenital malformations associated with maternal sociodemographic and risk factors? A multicenter ultrasound-based study |
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