The binding of the coenzyme pyridoxal 5'-phosphate and analogues of the substrate-coenzyme complex to tyrosine decarboxylase

Phosphopyridoxyl derivatives, which are stable analogues of a substrate-coenzyme complex, are bound at the active site with great affinity. From a comparison of the interaction of a number of such compounds with the apoenzyme the delta G0 values for the binding of the substrate carboxy and phenyl gr...

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Veröffentlicht in:	Biochemical journal 1980-01, Vol.185 (1), p.41-46
Hauptverfasser:	Orlacchio, A, Borri-Voltattorni, C, Turano, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Coenzymes - metabolism Kinetics Pyridoxal Phosphate - analogs & derivatives Pyridoxal Phosphate - metabolism Structure-Activity Relationship Temperature Thermodynamics Tyrosine Decarboxylase - metabolism Tyrosine Transaminase - metabolism
Online-Zugang:	Volltext
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