Repurposing of approved antivirals against dengue virus serotypes: an in silico and in vitro mechanistic study

Dengue is an emerging, mosquito-borne viral disease of international public health concern. Dengue is endemic in more than 100 countries across the world. However, there are no clinically approved antivirals for its cure. Drug repurposing proves to be an efficient alternative to conventional drug di...

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Veröffentlicht in:	Molecular diversity 2024-10, Vol.28 (5), p.2831-2844
Hauptverfasser:	Rashmi, S. H., Disha, K. Sai, Sudheesh, N., Karunakaran, Joseph, Joseph, Alex, Jagadesh, Anitha, Mudgal, P. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Naphthylamine Animals Antiviral Agents - chemistry Antiviral Agents - pharmacology Antiviral drugs Biochemistry Biomedical and Life Sciences Chlorocebus aethiops Computer Simulation Cytotoxicity Dengue - drug therapy Dengue - virology Dengue fever Dengue Virus - drug effects Drug development Drug Repositioning Hepatitis Humans Infections Life Sciences Molecular Docking Simulation Organic Chemistry Original Original Article Pharmacy Polymer Sciences RNA polymerase RNA-Dependent RNA Polymerase - antagonists & inhibitors RNA-Dependent RNA Polymerase - metabolism Serogroup Sulfonamides Uracil - analogs & derivatives Vero Cells Virus Replication - drug effects
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