Central effects of 5-HT on activity of respiratory and hypoglossally innervated muscles in newborn kittens
1. In decerebrate kittens (n = 29), electrical activity was studied in the 3rd intercartilaginous (inspiratory), the 9th internal intercostal (expiratory) and the hypoglossally innervated muscles (geniohyoid m. and sternohyoid m.) evoked by the application of 5-HT (n = 16) or related agents (5-HT1A...
Gespeichert in:
| Veröffentlicht in: | The Journal of physiology 1996-08, Vol.495 (Pt 1), p.255-265 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 265 |
|---|---|
| container_issue | Pt 1 |
| container_start_page | 255 |
| container_title | The Journal of physiology |
| container_volume | 495 |
| creator | Khater-Boidin, J Rose, D Duron, B |
| description | 1. In decerebrate kittens (n = 29), electrical activity was studied in the 3rd intercartilaginous (inspiratory), the 9th internal
intercostal (expiratory) and the hypoglossally innervated muscles (geniohyoid m. and sternohyoid m.) evoked by the application
of 5-HT (n = 16) or related agents (5-HT1A agonist, 8-OH-DPAT (n = 6) and 5-HT2 agonist, DOI floor of the IVth ventricle.
2. The application of a control solution (n = 2) produced no significant changes either in minute inspiratory frequency (Fi)
or in the electrical activity of the muscles studied. Except for these controls, only one trial with one dose of one drug
was performed in a given kitten. 3. A dose-related decrease in Fi was observed in response to 5-HT. Low doses (50-500 nmol,
n1 = 8) induced a long-lasting bradypnoea; high doses (5000-10,000 nmol, n2 = 8) induced prolonged periods of apnoea. 4. The
apnoeas observed in tracheotomized (n = 3) or non-tracheotomized (n2 = 8) kittens were mainly of central origin and linked
to the lengthening of expiratory time. The expiratory muscle activation came on with the reinforcement of the activity of
hypoglossally innervated muscles. 5. Application of agonists showed that both the 5-HT-dependent modulation of Fi and the
effects of 5-HT on the activity of the muscles studied resulted predominantly from activation of 5-HT2 receptors. |
| doi_str_mv | 10.1113/jphysiol.1996.sp021590 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1160741</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78440425</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5035-dcf6afb3ec1f23df45bd2a2925100388b0136d8e566d7f6729ec03dde22e220a3</originalsourceid><addsrcrecordid>eNqNUU2L1DAYLqKss6s_QcnJg9AxH03aXgQdXFdZcA_jOaTJ22nGTlKTzAz997Z0dtGbEAg8X3nfPFn2luA1IYR92A_dGK3v16SuxToOmBJe42fZihSizsuyZs-zFcaU5qzk5GV2HeMeY8JwXV9lV1UlBBPVKttvwKWgegRtCzpF5FvE87st8g4pnezJpnHGAsTBBpV8GJFyBnXj4He9j1H1_YiscxBOKoFBh2PUPcQJQg7OjQ8O_bIpgYuvshet6iO8vtw32c_bL9vNXX7_4-u3zaf7XHPMeG50K1TbMNCkpcy0BW8MVbSmnGDMqqqZlhCmAi6EKVtR0ho0ZsYApdPBit1kH5fc4dgcwOhlQTkEe1BhlF5Z-S_jbCd3_iQJEbgsyBTw7hIQ_O8jxCQPNmroe-XAH6Msq6LABeWTUCxCHaafCNA-PUKwnFuSjy3JuSX52NJkfPP3iE-2Sy0T_3nhz7aH8T9T5fb7wwwUNSeUz9O9X0I6u-vONoBcbNFrC2mUk04-JEnkLP4D5s-4kw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78440425</pqid></control><display><type>article</type><title>Central effects of 5-HT on activity of respiratory and hypoglossally innervated muscles in newborn kittens</title><source>MEDLINE</source><source>IngentaConnect Free/Open Access Journals</source><source>Wiley Online Library Journals Frontfile Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Khater-Boidin, J ; Rose, D ; Duron, B</creator><creatorcontrib>Khater-Boidin, J ; Rose, D ; Duron, B</creatorcontrib><description>1. In decerebrate kittens (n = 29), electrical activity was studied in the 3rd intercartilaginous (inspiratory), the 9th internal
intercostal (expiratory) and the hypoglossally innervated muscles (geniohyoid m. and sternohyoid m.) evoked by the application
of 5-HT (n = 16) or related agents (5-HT1A agonist, 8-OH-DPAT (n = 6) and 5-HT2 agonist, DOI floor of the IVth ventricle.
2. The application of a control solution (n = 2) produced no significant changes either in minute inspiratory frequency (Fi)
or in the electrical activity of the muscles studied. Except for these controls, only one trial with one dose of one drug
was performed in a given kitten. 3. A dose-related decrease in Fi was observed in response to 5-HT. Low doses (50-500 nmol,
n1 = 8) induced a long-lasting bradypnoea; high doses (5000-10,000 nmol, n2 = 8) induced prolonged periods of apnoea. 4. The
apnoeas observed in tracheotomized (n = 3) or non-tracheotomized (n2 = 8) kittens were mainly of central origin and linked
to the lengthening of expiratory time. The expiratory muscle activation came on with the reinforcement of the activity of
hypoglossally innervated muscles. 5. Application of agonists showed that both the 5-HT-dependent modulation of Fi and the
effects of 5-HT on the activity of the muscles studied resulted predominantly from activation of 5-HT2 receptors.</description><identifier>ISSN: 0022-3751</identifier><identifier>EISSN: 1469-7793</identifier><identifier>DOI: 10.1113/jphysiol.1996.sp021590</identifier><identifier>PMID: 8866368</identifier><language>eng</language><publisher>England: The Physiological Society</publisher><subject>Animals ; Animals, Newborn - physiology ; Cats ; Female ; Hypoglossal Nerve - drug effects ; Male ; Respiration - drug effects ; Respiratory Muscles - physiology ; Serotonin - pharmacology</subject><ispartof>The Journal of physiology, 1996-08, Vol.495 (Pt 1), p.255-265</ispartof><rights>1996 The Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5035-dcf6afb3ec1f23df45bd2a2925100388b0136d8e566d7f6729ec03dde22e220a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160741/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160741/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,27901,27902,45550,45551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8866368$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khater-Boidin, J</creatorcontrib><creatorcontrib>Rose, D</creatorcontrib><creatorcontrib>Duron, B</creatorcontrib><title>Central effects of 5-HT on activity of respiratory and hypoglossally innervated muscles in newborn kittens</title><title>The Journal of physiology</title><addtitle>J Physiol</addtitle><description>1. In decerebrate kittens (n = 29), electrical activity was studied in the 3rd intercartilaginous (inspiratory), the 9th internal
intercostal (expiratory) and the hypoglossally innervated muscles (geniohyoid m. and sternohyoid m.) evoked by the application
of 5-HT (n = 16) or related agents (5-HT1A agonist, 8-OH-DPAT (n = 6) and 5-HT2 agonist, DOI floor of the IVth ventricle.
2. The application of a control solution (n = 2) produced no significant changes either in minute inspiratory frequency (Fi)
or in the electrical activity of the muscles studied. Except for these controls, only one trial with one dose of one drug
was performed in a given kitten. 3. A dose-related decrease in Fi was observed in response to 5-HT. Low doses (50-500 nmol,
n1 = 8) induced a long-lasting bradypnoea; high doses (5000-10,000 nmol, n2 = 8) induced prolonged periods of apnoea. 4. The
apnoeas observed in tracheotomized (n = 3) or non-tracheotomized (n2 = 8) kittens were mainly of central origin and linked
to the lengthening of expiratory time. The expiratory muscle activation came on with the reinforcement of the activity of
hypoglossally innervated muscles. 5. Application of agonists showed that both the 5-HT-dependent modulation of Fi and the
effects of 5-HT on the activity of the muscles studied resulted predominantly from activation of 5-HT2 receptors.</description><subject>Animals</subject><subject>Animals, Newborn - physiology</subject><subject>Cats</subject><subject>Female</subject><subject>Hypoglossal Nerve - drug effects</subject><subject>Male</subject><subject>Respiration - drug effects</subject><subject>Respiratory Muscles - physiology</subject><subject>Serotonin - pharmacology</subject><issn>0022-3751</issn><issn>1469-7793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUU2L1DAYLqKss6s_QcnJg9AxH03aXgQdXFdZcA_jOaTJ22nGTlKTzAz997Z0dtGbEAg8X3nfPFn2luA1IYR92A_dGK3v16SuxToOmBJe42fZihSizsuyZs-zFcaU5qzk5GV2HeMeY8JwXV9lV1UlBBPVKttvwKWgegRtCzpF5FvE87st8g4pnezJpnHGAsTBBpV8GJFyBnXj4He9j1H1_YiscxBOKoFBh2PUPcQJQg7OjQ8O_bIpgYuvshet6iO8vtw32c_bL9vNXX7_4-u3zaf7XHPMeG50K1TbMNCkpcy0BW8MVbSmnGDMqqqZlhCmAi6EKVtR0ho0ZsYApdPBit1kH5fc4dgcwOhlQTkEe1BhlF5Z-S_jbCd3_iQJEbgsyBTw7hIQ_O8jxCQPNmroe-XAH6Msq6LABeWTUCxCHaafCNA-PUKwnFuSjy3JuSX52NJkfPP3iE-2Sy0T_3nhz7aH8T9T5fb7wwwUNSeUz9O9X0I6u-vONoBcbNFrC2mUk04-JEnkLP4D5s-4kw</recordid><startdate>19960815</startdate><enddate>19960815</enddate><creator>Khater-Boidin, J</creator><creator>Rose, D</creator><creator>Duron, B</creator><general>The Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19960815</creationdate><title>Central effects of 5-HT on activity of respiratory and hypoglossally innervated muscles in newborn kittens</title><author>Khater-Boidin, J ; Rose, D ; Duron, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5035-dcf6afb3ec1f23df45bd2a2925100388b0136d8e566d7f6729ec03dde22e220a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Animals, Newborn - physiology</topic><topic>Cats</topic><topic>Female</topic><topic>Hypoglossal Nerve - drug effects</topic><topic>Male</topic><topic>Respiration - drug effects</topic><topic>Respiratory Muscles - physiology</topic><topic>Serotonin - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khater-Boidin, J</creatorcontrib><creatorcontrib>Rose, D</creatorcontrib><creatorcontrib>Duron, B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khater-Boidin, J</au><au>Rose, D</au><au>Duron, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Central effects of 5-HT on activity of respiratory and hypoglossally innervated muscles in newborn kittens</atitle><jtitle>The Journal of physiology</jtitle><addtitle>J Physiol</addtitle><date>1996-08-15</date><risdate>1996</risdate><volume>495</volume><issue>Pt 1</issue><spage>255</spage><epage>265</epage><pages>255-265</pages><issn>0022-3751</issn><eissn>1469-7793</eissn><abstract>1. In decerebrate kittens (n = 29), electrical activity was studied in the 3rd intercartilaginous (inspiratory), the 9th internal
intercostal (expiratory) and the hypoglossally innervated muscles (geniohyoid m. and sternohyoid m.) evoked by the application
of 5-HT (n = 16) or related agents (5-HT1A agonist, 8-OH-DPAT (n = 6) and 5-HT2 agonist, DOI floor of the IVth ventricle.
2. The application of a control solution (n = 2) produced no significant changes either in minute inspiratory frequency (Fi)
or in the electrical activity of the muscles studied. Except for these controls, only one trial with one dose of one drug
was performed in a given kitten. 3. A dose-related decrease in Fi was observed in response to 5-HT. Low doses (50-500 nmol,
n1 = 8) induced a long-lasting bradypnoea; high doses (5000-10,000 nmol, n2 = 8) induced prolonged periods of apnoea. 4. The
apnoeas observed in tracheotomized (n = 3) or non-tracheotomized (n2 = 8) kittens were mainly of central origin and linked
to the lengthening of expiratory time. The expiratory muscle activation came on with the reinforcement of the activity of
hypoglossally innervated muscles. 5. Application of agonists showed that both the 5-HT-dependent modulation of Fi and the
effects of 5-HT on the activity of the muscles studied resulted predominantly from activation of 5-HT2 receptors.</abstract><cop>England</cop><pub>The Physiological Society</pub><pmid>8866368</pmid><doi>10.1113/jphysiol.1996.sp021590</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3751 |
| ispartof | The Journal of physiology, 1996-08, Vol.495 (Pt 1), p.255-265 |
| issn | 0022-3751 1469-7793 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1160741 |
| source | MEDLINE; IngentaConnect Free/Open Access Journals; Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Animals, Newborn - physiology Cats Female Hypoglossal Nerve - drug effects Male Respiration - drug effects Respiratory Muscles - physiology Serotonin - pharmacology |
| title | Central effects of 5-HT on activity of respiratory and hypoglossally innervated muscles in newborn kittens |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-14T22%3A56%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Central%20effects%20of%205-HT%20on%20activity%20of%20respiratory%20and%20hypoglossally%20innervated%20muscles%20in%20newborn%20kittens&rft.jtitle=The%20Journal%20of%20physiology&rft.au=Khater-Boidin,%20J&rft.date=1996-08-15&rft.volume=495&rft.issue=Pt%201&rft.spage=255&rft.epage=265&rft.pages=255-265&rft.issn=0022-3751&rft.eissn=1469-7793&rft_id=info:doi/10.1113/jphysiol.1996.sp021590&rft_dat=%3Cproquest_pubme%3E78440425%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78440425&rft_id=info:pmid/8866368&rfr_iscdi=true |