Specific and Plastic: Chandelier Cell-to-Axon Initial Segment Connections in Shaping Functional Cortical Network
Axon initial segment (AIS) is the most excitable subcellular domain of a neuron for action potential initiation. AISs of cortical projection neurons (PNs) receive GABAergic synaptic inputs primarily from chandelier cells (ChCs), which are believed to regulate action potential generation and modulate...
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| Veröffentlicht in: | Neuroscience bulletin 2024-11, Vol.40 (11), p.1774-1788 |
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| creator | Qi, Yanqing Zhao, Rui Tian, Jifeng Lu, Jiangteng He, Miao Tai, Yilin |
| description | Axon initial segment (AIS) is the most excitable subcellular domain of a neuron for action potential initiation. AISs of cortical projection neurons (PNs) receive GABAergic synaptic inputs primarily from chandelier cells (ChCs), which are believed to regulate action potential generation and modulate neuronal excitability. As individual ChCs often innervate hundreds of PNs, they may alter the activity of PN ensembles and even impact the entire neural network. During postnatal development or in response to changes in network activity, the AISs and axo-axonic synapses undergo dynamic structural and functional changes that underlie the wiring, refinement, and adaptation of cortical microcircuits. Here we briefly introduce the history of ChCs and review recent research advances employing modern genetic and molecular tools. Special attention will be attributed to the plasticity of the AIS and the ChC-PN connections, which play a pivotal role in shaping the dynamic network under both physiological and pathological conditions. |
| doi_str_mv | 10.1007/s12264-024-01266-3 |
| format | Article |
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AISs of cortical projection neurons (PNs) receive GABAergic synaptic inputs primarily from chandelier cells (ChCs), which are believed to regulate action potential generation and modulate neuronal excitability. As individual ChCs often innervate hundreds of PNs, they may alter the activity of PN ensembles and even impact the entire neural network. During postnatal development or in response to changes in network activity, the AISs and axo-axonic synapses undergo dynamic structural and functional changes that underlie the wiring, refinement, and adaptation of cortical microcircuits. Here we briefly introduce the history of ChCs and review recent research advances employing modern genetic and molecular tools. 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Bull</addtitle><addtitle>Neurosci Bull</addtitle><description>Axon initial segment (AIS) is the most excitable subcellular domain of a neuron for action potential initiation. AISs of cortical projection neurons (PNs) receive GABAergic synaptic inputs primarily from chandelier cells (ChCs), which are believed to regulate action potential generation and modulate neuronal excitability. As individual ChCs often innervate hundreds of PNs, they may alter the activity of PN ensembles and even impact the entire neural network. During postnatal development or in response to changes in network activity, the AISs and axo-axonic synapses undergo dynamic structural and functional changes that underlie the wiring, refinement, and adaptation of cortical microcircuits. Here we briefly introduce the history of ChCs and review recent research advances employing modern genetic and molecular tools. 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Bull</stitle><addtitle>Neurosci Bull</addtitle><date>2024-11-01</date><risdate>2024</risdate><volume>40</volume><issue>11</issue><spage>1774</spage><epage>1788</epage><pages>1774-1788</pages><issn>1673-7067</issn><issn>1995-8218</issn><eissn>1995-8218</eissn><abstract>Axon initial segment (AIS) is the most excitable subcellular domain of a neuron for action potential initiation. AISs of cortical projection neurons (PNs) receive GABAergic synaptic inputs primarily from chandelier cells (ChCs), which are believed to regulate action potential generation and modulate neuronal excitability. As individual ChCs often innervate hundreds of PNs, they may alter the activity of PN ensembles and even impact the entire neural network. During postnatal development or in response to changes in network activity, the AISs and axo-axonic synapses undergo dynamic structural and functional changes that underlie the wiring, refinement, and adaptation of cortical microcircuits. 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| identifier | ISSN: 1673-7067 |
| ispartof | Neuroscience bulletin, 2024-11, Vol.40 (11), p.1774-1788 |
| issn | 1673-7067 1995-8218 1995-8218 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection; SpringerLink Journals - AutoHoldings |
| subjects | Anatomy Anesthesiology Animals Axons - physiology Biomedical and Life Sciences Biomedicine Cerebral Cortex - cytology Cerebral Cortex - physiology GABAergic Neurons - physiology Human Physiology Humans Nerve Net - physiology Neurology Neuronal Plasticity - physiology Neurosciences Pain Medicine Review Synapses - physiology |
| title | Specific and Plastic: Chandelier Cell-to-Axon Initial Segment Connections in Shaping Functional Cortical Network |
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