Investigation of Metabolic and Inflammatory Disorder in the Aging FGF21 Knockout Mouse

Aging is a physiological condition accomplished with persistent low-grade inflammation and metabolic disorders. FGF21 has been reported to act as a potent longevity determinant, involving inflammatory response and energy metabolism. In this study, we engineered aging FGF21 knockout mice of 36–40 wee...

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Veröffentlicht in:	Inflammation 2024-12, Vol.47 (6), p.2173-2195
Hauptverfasser:	Cai, Lu-Qiong, Li, Xiu-Chun, Wang, Yang-Yue, Chen, Yu-Xin, Zhu, Xia-Yan, Zuo, Zi-Yi, Si-Ma, Yi-Qun, Lin, Yi-Nuo, Li, Xiao-Kun, Huang, Xiao-Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - metabolism Amino acids Animals Biomedical and Life Sciences Biomedicine Energy Metabolism Fatty liver Fatty Liver - metabolism Fatty Liver - pathology Fibroblast Growth Factors - genetics Fibroblast Growth Factors - metabolism Glucose metabolism Hepatocytes Immunology Inflammation - metabolism Inflammatory diseases Internal Medicine Lipid Metabolism Liver - metabolism Liver - pathology Metabolic Diseases - genetics Metabolic Diseases - metabolism Metabolic disorders Metabolism Metabolomics Mice Mice, Knockout Microvasculature Pathology Pharmacology/Toxicology Phenotypes Rheumatology Triglycerides
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