Effects of Resveratrol on Nonmelanoma Skin Cancer (NMSC): A Comprehensive Review
ABSTRACT Nonmelanoma skin cancer (NMSC) represents the most prevalent form of skin cancer globally, with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) being the most common types. The search for effective chemopreventive and therapeutic agents has led to the exploration of natural com...
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| creator | Zamanian, Mohammad Yasin Shahbazi, Taha Kazmi, Syeda Wajida Hussien, Beneen M. Sharma, Abhishek Qasim, Maytham T. Hjazi, Ahmed Sapaev, Ibrohim B. Nouri Danesh, Ayda Taheri, Niloofar Golmohammadi, Maryam |
| description | ABSTRACT
Nonmelanoma skin cancer (NMSC) represents the most prevalent form of skin cancer globally, with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) being the most common types. The search for effective chemopreventive and therapeutic agents has led to the exploration of natural compounds, among which resveratrol (RES), a polyphenolic phytoalexin found in grapes, berries, peanuts, and red wine, has garnered significant attention. This comprehensive review aims to elucidate the effects of RES on NMSC, focusing on its mechanisms of action, efficacy in preclinical studies, and potential as a chemopreventive and therapeutic agent. RES exhibits promising chemopreventive and antineoplastic capabilities against NMSC through various mechanisms, including the induction of apoptosis, inhibition of cell proliferation, modulation of oxidative stress, and anti‐inflammatory activities. Studies have demonstrated that RES can significantly enhance the effectiveness of traditional chemotherapeutic agents, such as 5‐fluorouracil (5‐FU), by inhibiting cellular proliferation and inducing apoptosis in cancerous cells. Furthermore, resveratrol's antioxidant properties may mitigate the impact of reactive oxygen species (ROS) triggered by UV exposure, thus reducing DNA damage and mutations associated with skin cancer development. In vitro and in vivo experiments have shown that RES can effectively hinder the growth and spread of various tumor cell types, including human cutaneous SCC A431 cells, and induce apoptosis. The development of advanced delivery systems, such as nanostructured lipid carriers and liposomes, has been recognized for their potential to enhance the therapeutic effects of RES, particularly its anticancer properties. In conclusion, RES presents a viable candidate for the prevention and treatment of NMSC, owing to its multifaceted mechanisms of action, including its ability to regulate oxidative stress, trigger apoptosis, and inhibit proliferation. However, further clinical studies are required to fully understand its effectiveness and safety in humans, as well as to optimize delivery methods for improved bioavailability and therapeutic outcomes.
Resveratrol (RES), a natural phytoalexin found in grapes and other plants, has shown promising chemopreventive and antineoplastic properties against nonmelanoma skin cancer (NMSC). It operates through various mechanisms, including the modulation of oxidative stress, induction of apoptosis, and inhibition |
| doi_str_mv | 10.1002/fsn3.4555 |
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Nonmelanoma skin cancer (NMSC) represents the most prevalent form of skin cancer globally, with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) being the most common types. The search for effective chemopreventive and therapeutic agents has led to the exploration of natural compounds, among which resveratrol (RES), a polyphenolic phytoalexin found in grapes, berries, peanuts, and red wine, has garnered significant attention. This comprehensive review aims to elucidate the effects of RES on NMSC, focusing on its mechanisms of action, efficacy in preclinical studies, and potential as a chemopreventive and therapeutic agent. RES exhibits promising chemopreventive and antineoplastic capabilities against NMSC through various mechanisms, including the induction of apoptosis, inhibition of cell proliferation, modulation of oxidative stress, and anti‐inflammatory activities. Studies have demonstrated that RES can significantly enhance the effectiveness of traditional chemotherapeutic agents, such as 5‐fluorouracil (5‐FU), by inhibiting cellular proliferation and inducing apoptosis in cancerous cells. Furthermore, resveratrol's antioxidant properties may mitigate the impact of reactive oxygen species (ROS) triggered by UV exposure, thus reducing DNA damage and mutations associated with skin cancer development. In vitro and in vivo experiments have shown that RES can effectively hinder the growth and spread of various tumor cell types, including human cutaneous SCC A431 cells, and induce apoptosis. The development of advanced delivery systems, such as nanostructured lipid carriers and liposomes, has been recognized for their potential to enhance the therapeutic effects of RES, particularly its anticancer properties. In conclusion, RES presents a viable candidate for the prevention and treatment of NMSC, owing to its multifaceted mechanisms of action, including its ability to regulate oxidative stress, trigger apoptosis, and inhibit proliferation. However, further clinical studies are required to fully understand its effectiveness and safety in humans, as well as to optimize delivery methods for improved bioavailability and therapeutic outcomes.
Resveratrol (RES), a natural phytoalexin found in grapes and other plants, has shown promising chemopreventive and antineoplastic properties against nonmelanoma skin cancer (NMSC). It operates through various mechanisms, including the modulation of oxidative stress, induction of apoptosis, and inhibition of cell proliferation. This review highlights the potential of RES, particularly when combined with 5‐fluorouracil (5‐FU) and delivered through advanced lipid–nanocarrier systems, to enhance the effectiveness of NMSC treatments.</description><identifier>ISSN: 2048-7177</identifier><identifier>EISSN: 2048-7177</identifier><identifier>DOI: 10.1002/fsn3.4555</identifier><identifier>PMID: 39620024</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>5-Fluorouracil ; A431 cell line ; Anticancer properties ; Antineoplastic drugs ; Apoptosis ; Basal cell carcinoma ; Bioavailability ; Cancer therapies ; Cell proliferation ; Chemotherapy ; Cytokines ; Dietary guidelines ; DNA damage ; Effectiveness ; Human papillomavirus ; Insulin-like growth factors ; Kinases ; Lipids ; Melanoma ; Mortality ; Mutation ; nonmelanoma skin cancer ; Nutrients ; Oxidative stress ; Pathogenesis ; Pharmacology ; Proteins ; Reactive oxygen species ; Resveratrol ; Review ; Skin cancer ; Squamous cell carcinoma ; Tumor necrosis factor-TNF ; Tumors ; Ultraviolet radiation ; Vascular endothelial growth factor ; Vitamin D ; Wines</subject><ispartof>Food science & nutrition, 2024-11, Vol.12 (11), p.8825-8845</ispartof><rights>2024 The Author(s). published by Wiley Periodicals LLC.</rights><rights>2024 The Author(s). Food Science & Nutrition published by Wiley Periodicals LLC.</rights><rights>2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3345-5792bbc84c1cde1fdca35c5928762d5685561eb69ba5bbf382bef864147672953</cites><orcidid>0000-0003-0944-0320</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11606877/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11606877/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,11562,27924,27925,45574,45575,46052,46476,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39620024$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zamanian, Mohammad Yasin</creatorcontrib><creatorcontrib>Shahbazi, Taha</creatorcontrib><creatorcontrib>Kazmi, Syeda Wajida</creatorcontrib><creatorcontrib>Hussien, Beneen M.</creatorcontrib><creatorcontrib>Sharma, Abhishek</creatorcontrib><creatorcontrib>Qasim, Maytham T.</creatorcontrib><creatorcontrib>Hjazi, Ahmed</creatorcontrib><creatorcontrib>Sapaev, Ibrohim B.</creatorcontrib><creatorcontrib>Nouri Danesh, Ayda</creatorcontrib><creatorcontrib>Taheri, Niloofar</creatorcontrib><creatorcontrib>Golmohammadi, Maryam</creatorcontrib><title>Effects of Resveratrol on Nonmelanoma Skin Cancer (NMSC): A Comprehensive Review</title><title>Food science & nutrition</title><addtitle>Food Sci Nutr</addtitle><description>ABSTRACT
Nonmelanoma skin cancer (NMSC) represents the most prevalent form of skin cancer globally, with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) being the most common types. The search for effective chemopreventive and therapeutic agents has led to the exploration of natural compounds, among which resveratrol (RES), a polyphenolic phytoalexin found in grapes, berries, peanuts, and red wine, has garnered significant attention. This comprehensive review aims to elucidate the effects of RES on NMSC, focusing on its mechanisms of action, efficacy in preclinical studies, and potential as a chemopreventive and therapeutic agent. RES exhibits promising chemopreventive and antineoplastic capabilities against NMSC through various mechanisms, including the induction of apoptosis, inhibition of cell proliferation, modulation of oxidative stress, and anti‐inflammatory activities. Studies have demonstrated that RES can significantly enhance the effectiveness of traditional chemotherapeutic agents, such as 5‐fluorouracil (5‐FU), by inhibiting cellular proliferation and inducing apoptosis in cancerous cells. Furthermore, resveratrol's antioxidant properties may mitigate the impact of reactive oxygen species (ROS) triggered by UV exposure, thus reducing DNA damage and mutations associated with skin cancer development. In vitro and in vivo experiments have shown that RES can effectively hinder the growth and spread of various tumor cell types, including human cutaneous SCC A431 cells, and induce apoptosis. The development of advanced delivery systems, such as nanostructured lipid carriers and liposomes, has been recognized for their potential to enhance the therapeutic effects of RES, particularly its anticancer properties. In conclusion, RES presents a viable candidate for the prevention and treatment of NMSC, owing to its multifaceted mechanisms of action, including its ability to regulate oxidative stress, trigger apoptosis, and inhibit proliferation. However, further clinical studies are required to fully understand its effectiveness and safety in humans, as well as to optimize delivery methods for improved bioavailability and therapeutic outcomes.
Resveratrol (RES), a natural phytoalexin found in grapes and other plants, has shown promising chemopreventive and antineoplastic properties against nonmelanoma skin cancer (NMSC). It operates through various mechanisms, including the modulation of oxidative stress, induction of apoptosis, and inhibition of cell proliferation. This review highlights the potential of RES, particularly when combined with 5‐fluorouracil (5‐FU) and delivered through advanced lipid–nanocarrier systems, to enhance the effectiveness of NMSC treatments.</description><subject>5-Fluorouracil</subject><subject>A431 cell line</subject><subject>Anticancer properties</subject><subject>Antineoplastic drugs</subject><subject>Apoptosis</subject><subject>Basal cell carcinoma</subject><subject>Bioavailability</subject><subject>Cancer therapies</subject><subject>Cell proliferation</subject><subject>Chemotherapy</subject><subject>Cytokines</subject><subject>Dietary guidelines</subject><subject>DNA damage</subject><subject>Effectiveness</subject><subject>Human papillomavirus</subject><subject>Insulin-like growth factors</subject><subject>Kinases</subject><subject>Lipids</subject><subject>Melanoma</subject><subject>Mortality</subject><subject>Mutation</subject><subject>nonmelanoma skin cancer</subject><subject>Nutrients</subject><subject>Oxidative stress</subject><subject>Pathogenesis</subject><subject>Pharmacology</subject><subject>Proteins</subject><subject>Reactive oxygen species</subject><subject>Resveratrol</subject><subject>Review</subject><subject>Skin cancer</subject><subject>Squamous cell carcinoma</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumors</subject><subject>Ultraviolet radiation</subject><subject>Vascular endothelial growth factor</subject><subject>Vitamin 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of Resveratrol on Nonmelanoma Skin Cancer (NMSC): A Comprehensive Review</title><author>Zamanian, Mohammad Yasin ; Shahbazi, Taha ; Kazmi, Syeda Wajida ; Hussien, Beneen M. ; Sharma, Abhishek ; Qasim, Maytham T. ; Hjazi, Ahmed ; Sapaev, Ibrohim B. ; Nouri Danesh, Ayda ; Taheri, Niloofar ; Golmohammadi, Maryam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3345-5792bbc84c1cde1fdca35c5928762d5685561eb69ba5bbf382bef864147672953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>5-Fluorouracil</topic><topic>A431 cell line</topic><topic>Anticancer properties</topic><topic>Antineoplastic drugs</topic><topic>Apoptosis</topic><topic>Basal cell carcinoma</topic><topic>Bioavailability</topic><topic>Cancer therapies</topic><topic>Cell proliferation</topic><topic>Chemotherapy</topic><topic>Cytokines</topic><topic>Dietary guidelines</topic><topic>DNA 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zamanian, Mohammad Yasin</au><au>Shahbazi, Taha</au><au>Kazmi, Syeda Wajida</au><au>Hussien, Beneen M.</au><au>Sharma, Abhishek</au><au>Qasim, Maytham T.</au><au>Hjazi, Ahmed</au><au>Sapaev, Ibrohim B.</au><au>Nouri Danesh, Ayda</au><au>Taheri, Niloofar</au><au>Golmohammadi, Maryam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Resveratrol on Nonmelanoma Skin Cancer (NMSC): A Comprehensive Review</atitle><jtitle>Food science & nutrition</jtitle><addtitle>Food Sci Nutr</addtitle><date>2024-11</date><risdate>2024</risdate><volume>12</volume><issue>11</issue><spage>8825</spage><epage>8845</epage><pages>8825-8845</pages><issn>2048-7177</issn><eissn>2048-7177</eissn><abstract>ABSTRACT
Nonmelanoma skin cancer (NMSC) represents the most prevalent form of skin cancer globally, with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) being the most common types. The search for effective chemopreventive and therapeutic agents has led to the exploration of natural compounds, among which resveratrol (RES), a polyphenolic phytoalexin found in grapes, berries, peanuts, and red wine, has garnered significant attention. This comprehensive review aims to elucidate the effects of RES on NMSC, focusing on its mechanisms of action, efficacy in preclinical studies, and potential as a chemopreventive and therapeutic agent. RES exhibits promising chemopreventive and antineoplastic capabilities against NMSC through various mechanisms, including the induction of apoptosis, inhibition of cell proliferation, modulation of oxidative stress, and anti‐inflammatory activities. Studies have demonstrated that RES can significantly enhance the effectiveness of traditional chemotherapeutic agents, such as 5‐fluorouracil (5‐FU), by inhibiting cellular proliferation and inducing apoptosis in cancerous cells. Furthermore, resveratrol's antioxidant properties may mitigate the impact of reactive oxygen species (ROS) triggered by UV exposure, thus reducing DNA damage and mutations associated with skin cancer development. In vitro and in vivo experiments have shown that RES can effectively hinder the growth and spread of various tumor cell types, including human cutaneous SCC A431 cells, and induce apoptosis. The development of advanced delivery systems, such as nanostructured lipid carriers and liposomes, has been recognized for their potential to enhance the therapeutic effects of RES, particularly its anticancer properties. In conclusion, RES presents a viable candidate for the prevention and treatment of NMSC, owing to its multifaceted mechanisms of action, including its ability to regulate oxidative stress, trigger apoptosis, and inhibit proliferation. However, further clinical studies are required to fully understand its effectiveness and safety in humans, as well as to optimize delivery methods for improved bioavailability and therapeutic outcomes.
Resveratrol (RES), a natural phytoalexin found in grapes and other plants, has shown promising chemopreventive and antineoplastic properties against nonmelanoma skin cancer (NMSC). It operates through various mechanisms, including the modulation of oxidative stress, induction of apoptosis, and inhibition of cell proliferation. This review highlights the potential of RES, particularly when combined with 5‐fluorouracil (5‐FU) and delivered through advanced lipid–nanocarrier systems, to enhance the effectiveness of NMSC treatments.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>39620024</pmid><doi>10.1002/fsn3.4555</doi><tpages>21</tpages><orcidid>https://orcid.org/0000-0003-0944-0320</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Food science & nutrition, 2024-11, Vol.12 (11), p.8825-8845 |
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| source | Access via Wiley Online Library; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection); PubMed Central |
| subjects | 5-Fluorouracil A431 cell line Anticancer properties Antineoplastic drugs Apoptosis Basal cell carcinoma Bioavailability Cancer therapies Cell proliferation Chemotherapy Cytokines Dietary guidelines DNA damage Effectiveness Human papillomavirus Insulin-like growth factors Kinases Lipids Melanoma Mortality Mutation nonmelanoma skin cancer Nutrients Oxidative stress Pathogenesis Pharmacology Proteins Reactive oxygen species Resveratrol Review Skin cancer Squamous cell carcinoma Tumor necrosis factor-TNF Tumors Ultraviolet radiation Vascular endothelial growth factor Vitamin D Wines |
| title | Effects of Resveratrol on Nonmelanoma Skin Cancer (NMSC): A Comprehensive Review |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T21%3A12%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20Resveratrol%20on%20Nonmelanoma%20Skin%20Cancer%20(NMSC):%20A%20Comprehensive%20Review&rft.jtitle=Food%20science%20&%20nutrition&rft.au=Zamanian,%20Mohammad%C2%A0Yasin&rft.date=2024-11&rft.volume=12&rft.issue=11&rft.spage=8825&rft.epage=8845&rft.pages=8825-8845&rft.issn=2048-7177&rft.eissn=2048-7177&rft_id=info:doi/10.1002/fsn3.4555&rft_dat=%3Cproquest_pubme%3E3140920278%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3134164303&rft_id=info:pmid/39620024&rfr_iscdi=true |