Voltage- and time-dependent block of delayed rectifier K+ current in rabbit sino-atrial node cells by external Ca2+ and Mg2

1. The properties of the delayed rectifier K+ current (IK) of rabbit isolated sino-atrial node cells were investigated in high (140 mM) [K+]o using the whole-cell-clamp technique. 2. Hyperpolarizing clamp pulses from 0 mV induced an instantaneous current jump (I-V relation linear) followed by a time...

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Veröffentlicht in:	The Journal of physiology 1996-08, Vol.494 (Pt 3), p.727-742
Hauptverfasser:	Ho, W K, Earm, Y E, Lee, S H, Brown, H F, Noble, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - pharmacology Dose-Response Relationship, Drug Magnesium - pharmacology Membrane Potentials - drug effects Patch-Clamp Techniques Potassium Channels - drug effects Rabbits Sinoatrial Node - drug effects
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