Bifidobacterium breve M‐16 V and scGOS/lcFOS Supplementation to Dams Ameliorates Infant Rotavirus Infection in Early Life
The immune system of newborns is underdeveloped, leaving them susceptible to infections like rotavirus (RV). Despite vaccines, RV remains a leading cause of child mortality, especially in developing countries. Maternal immunity is transferred during pregnancy and breastfeeding to the offspring provi...
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| Veröffentlicht in: | Molecular nutrition & food research 2024-11, Vol.68 (22), p.e2400377-n/a |
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| creator | Sáez‐Fuertes, Laura Rio‐Aige, Karla Massot‐Cladera, Malén Castell, Margarida Knipping, Karen Garssen, Johan Bourdet‐Sicard, Raphaëlle Rodríguez‐Lagunas, María José Collado, María Carmen Pérez‐Cano, Francisco José |
| description | The immune system of newborns is underdeveloped, leaving them susceptible to infections like rotavirus (RV). Despite vaccines, RV remains a leading cause of child mortality, especially in developing countries. Maternal immunity is transferred during pregnancy and breastfeeding to the offspring providing protection against RV infection. This study aims to explore how the maternal diet can enhance the newborn's ability to fight early infections. Pregnant rats received orally Bifidobacterium breve M‐16 V and short chain galacto‐oligosaccharides (scGOS)/long chain fructo‐oligosaccharides (lcFOS). At day 5 of life pups are infected with RV and at day 8, samples are collected for the infection analysis. Pups whose mothers received the synbiotic have lower RV infection severity. The levels of immunoglobulins (Ig) IgG2c and IgA are raised in pups' plasma and digested milk, respectively. Synbiotic supplementation improves intestinal maturation and increases gene expression of immune‐related genes. In conclusion, the administration of this synbiotic to gestating and lactating mothers ameliorates the incidence and severity of the pup's diarrhea caused by the RV infection by improving their immunity.
The graphical illustrates the impact of maternal synbiotic supplementation with Bifidobacterium breve M‐16V and a mixture of short‐chain galacto‐oligosaccharides (scGOS) and long‐chain fructooligosaccharides (lcFOS) during gestation and lactation on the offspring's response to rotavirus (RV) infection in early life. Following maternal supplementation, the offspring of the supplemented dams exhibited reduced severity and incidence of infection. Additionally, the immunoglobulin profile, intestinal functionality, and microbiota composition of the offspring were modulated as a result of the maternal supplementation |
| doi_str_mv | 10.1002/mnfr.202400377 |
| format | Article |
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The graphical illustrates the impact of maternal synbiotic supplementation with Bifidobacterium breve M‐16V and a mixture of short‐chain galacto‐oligosaccharides (scGOS) and long‐chain fructooligosaccharides (lcFOS) during gestation and lactation on the offspring's response to rotavirus (RV) infection in early life. Following maternal supplementation, the offspring of the supplemented dams exhibited reduced severity and incidence of infection. Additionally, the immunoglobulin profile, intestinal functionality, and microbiota composition of the offspring were modulated as a result of the maternal supplementation</description><identifier>ISSN: 1613-4125</identifier><identifier>ISSN: 1613-4133</identifier><identifier>EISSN: 1613-4133</identifier><identifier>DOI: 10.1002/mnfr.202400377</identifier><identifier>PMID: 39468988</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Animals ; Animals, Newborn ; Bifidobacterium breve ; Bifidobacterium breve M‐16V ; Breast feeding ; children ; Developing countries ; Diarrhea ; Diarrhea - prevention & control ; Dietary Supplements ; Female ; food research ; fructooligosaccharides ; galactooligosaccharides ; Gene expression ; Immune system ; Immunity ; Immunity (Disease) ; Immunoglobulin A ; Immunoglobulin A - blood ; Immunoglobulins ; infancy ; Infections ; intestines ; Juveniles ; LDCs ; long chain fructo‐oligosaccharides (lcFOS) ; maternal immunity ; maternal nutrition ; Milk ; mortality ; Neonates ; Offspring ; Oligosaccharides ; Oligosaccharides - administration & dosage ; Oligosaccharides - pharmacology ; Pregnancy ; Rats ; Rats, Sprague-Dawley ; Rotavirus ; Rotavirus - immunology ; Rotavirus Infections - immunology ; Rotavirus Infections - prevention & control ; short chain galacto‐oligosaccharides (scGOS) ; Synbiotics - administration & dosage ; Viruses</subject><ispartof>Molecular nutrition & food research, 2024-11, Vol.68 (22), p.e2400377-n/a</ispartof><rights>2024 The Author(s). Molecular Nutrition & Food Research published by Wiley‐VCH GmbH</rights><rights>2024 The Author(s). Molecular Nutrition & Food Research published by Wiley‐VCH GmbH.</rights><rights>2024. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3822-8670c3fdf122026bd5ede7ad2929c8cbfa89a11997606083c46acb228897f9cc3</cites><orcidid>0000-0001-7870-8250 ; 0000-0002-6204-4864 ; 0000-0002-5220-2793</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmnfr.202400377$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmnfr.202400377$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39468988$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sáez‐Fuertes, Laura</creatorcontrib><creatorcontrib>Rio‐Aige, Karla</creatorcontrib><creatorcontrib>Massot‐Cladera, Malén</creatorcontrib><creatorcontrib>Castell, Margarida</creatorcontrib><creatorcontrib>Knipping, Karen</creatorcontrib><creatorcontrib>Garssen, Johan</creatorcontrib><creatorcontrib>Bourdet‐Sicard, Raphaëlle</creatorcontrib><creatorcontrib>Rodríguez‐Lagunas, María José</creatorcontrib><creatorcontrib>Collado, María Carmen</creatorcontrib><creatorcontrib>Pérez‐Cano, Francisco José</creatorcontrib><title>Bifidobacterium breve M‐16 V and scGOS/lcFOS Supplementation to Dams Ameliorates Infant Rotavirus Infection in Early Life</title><title>Molecular nutrition & food research</title><addtitle>Mol Nutr Food Res</addtitle><description>The immune system of newborns is underdeveloped, leaving them susceptible to infections like rotavirus (RV). Despite vaccines, RV remains a leading cause of child mortality, especially in developing countries. Maternal immunity is transferred during pregnancy and breastfeeding to the offspring providing protection against RV infection. This study aims to explore how the maternal diet can enhance the newborn's ability to fight early infections. Pregnant rats received orally Bifidobacterium breve M‐16 V and short chain galacto‐oligosaccharides (scGOS)/long chain fructo‐oligosaccharides (lcFOS). At day 5 of life pups are infected with RV and at day 8, samples are collected for the infection analysis. Pups whose mothers received the synbiotic have lower RV infection severity. The levels of immunoglobulins (Ig) IgG2c and IgA are raised in pups' plasma and digested milk, respectively. Synbiotic supplementation improves intestinal maturation and increases gene expression of immune‐related genes. In conclusion, the administration of this synbiotic to gestating and lactating mothers ameliorates the incidence and severity of the pup's diarrhea caused by the RV infection by improving their immunity.
The graphical illustrates the impact of maternal synbiotic supplementation with Bifidobacterium breve M‐16V and a mixture of short‐chain galacto‐oligosaccharides (scGOS) and long‐chain fructooligosaccharides (lcFOS) during gestation and lactation on the offspring's response to rotavirus (RV) infection in early life. Following maternal supplementation, the offspring of the supplemented dams exhibited reduced severity and incidence of infection. Additionally, the immunoglobulin profile, intestinal functionality, and microbiota composition of the offspring were modulated as a result of the maternal supplementation</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Bifidobacterium breve</subject><subject>Bifidobacterium breve M‐16V</subject><subject>Breast feeding</subject><subject>children</subject><subject>Developing countries</subject><subject>Diarrhea</subject><subject>Diarrhea - prevention & control</subject><subject>Dietary Supplements</subject><subject>Female</subject><subject>food research</subject><subject>fructooligosaccharides</subject><subject>galactooligosaccharides</subject><subject>Gene expression</subject><subject>Immune system</subject><subject>Immunity</subject><subject>Immunity (Disease)</subject><subject>Immunoglobulin A</subject><subject>Immunoglobulin A - blood</subject><subject>Immunoglobulins</subject><subject>infancy</subject><subject>Infections</subject><subject>intestines</subject><subject>Juveniles</subject><subject>LDCs</subject><subject>long chain fructo‐oligosaccharides (lcFOS)</subject><subject>maternal immunity</subject><subject>maternal nutrition</subject><subject>Milk</subject><subject>mortality</subject><subject>Neonates</subject><subject>Offspring</subject><subject>Oligosaccharides</subject><subject>Oligosaccharides - administration & dosage</subject><subject>Oligosaccharides - pharmacology</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rotavirus</subject><subject>Rotavirus - immunology</subject><subject>Rotavirus Infections - immunology</subject><subject>Rotavirus Infections - prevention & control</subject><subject>short chain galacto‐oligosaccharides (scGOS)</subject><subject>Synbiotics - administration & dosage</subject><subject>Viruses</subject><issn>1613-4125</issn><issn>1613-4133</issn><issn>1613-4133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNqN0s9uFCEcB_CJ0dhavXo0JF687JZ_w8DJ1NqtTbZu0lWvhGFAaRhYYWbNJh58BB_BZ_FRfBLZbt2oFz1B4MM3P-BXVY8RnCII8XEfbJpiiCmEpGnuVIeIITKhiJC7-zmuD6oHOV8XgjAl96sDIijjgvPD6vMLZ10XW6UHk9zYgzaZtQGXP758Rez7t3dAhQ5kfb5YHns9WyzBclytvOlNGNTgYgBDBC9Vn8FJb7yLSQ0mg4tgVRjAVRzU2qXxZsHoG-4COFPJb8DcWfOwumeVz-bR7XhUvZ2dvTl9NZkvzi9OT-YTTTjGE84aqIntLMLlpqztatOZRnVYYKG5bq3iQiEkRMMgg5xoypRuMeZcNFZoTY6q57vc1dj2ptOl-KS8XCXXq7SRUTn5505wH-T7uJYIMVg3nJWEZ7cJKX4cTR5k77I23qtg4pglQTXFjGL6PxSjWmBWb-nTv-h1HFMoT1EUIUJwDJuipjulU8w5GbsvHEG5bQK5bQK5b4Jy4Mnv193zX79eAN2BT86bzT_i5OXr2RUVEJOfade_WA</recordid><startdate>202411</startdate><enddate>202411</enddate><creator>Sáez‐Fuertes, Laura</creator><creator>Rio‐Aige, Karla</creator><creator>Massot‐Cladera, Malén</creator><creator>Castell, Margarida</creator><creator>Knipping, Karen</creator><creator>Garssen, Johan</creator><creator>Bourdet‐Sicard, Raphaëlle</creator><creator>Rodríguez‐Lagunas, María José</creator><creator>Collado, María Carmen</creator><creator>Pérez‐Cano, Francisco José</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7870-8250</orcidid><orcidid>https://orcid.org/0000-0002-6204-4864</orcidid><orcidid>https://orcid.org/0000-0002-5220-2793</orcidid></search><sort><creationdate>202411</creationdate><title>Bifidobacterium breve M‐16 V and scGOS/lcFOS Supplementation to Dams Ameliorates Infant Rotavirus Infection in Early Life</title><author>Sáez‐Fuertes, Laura ; Rio‐Aige, Karla ; Massot‐Cladera, Malén ; Castell, Margarida ; Knipping, Karen ; Garssen, Johan ; Bourdet‐Sicard, Raphaëlle ; Rodríguez‐Lagunas, María José ; Collado, María Carmen ; Pérez‐Cano, Francisco José</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3822-8670c3fdf122026bd5ede7ad2929c8cbfa89a11997606083c46acb228897f9cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Bifidobacterium breve</topic><topic>Bifidobacterium breve M‐16V</topic><topic>Breast feeding</topic><topic>children</topic><topic>Developing countries</topic><topic>Diarrhea</topic><topic>Diarrhea - prevention & control</topic><topic>Dietary Supplements</topic><topic>Female</topic><topic>food research</topic><topic>fructooligosaccharides</topic><topic>galactooligosaccharides</topic><topic>Gene expression</topic><topic>Immune system</topic><topic>Immunity</topic><topic>Immunity (Disease)</topic><topic>Immunoglobulin A</topic><topic>Immunoglobulin A - blood</topic><topic>Immunoglobulins</topic><topic>infancy</topic><topic>Infections</topic><topic>intestines</topic><topic>Juveniles</topic><topic>LDCs</topic><topic>long chain fructo‐oligosaccharides (lcFOS)</topic><topic>maternal immunity</topic><topic>maternal nutrition</topic><topic>Milk</topic><topic>mortality</topic><topic>Neonates</topic><topic>Offspring</topic><topic>Oligosaccharides</topic><topic>Oligosaccharides - administration & dosage</topic><topic>Oligosaccharides - pharmacology</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rotavirus</topic><topic>Rotavirus - immunology</topic><topic>Rotavirus Infections - immunology</topic><topic>Rotavirus Infections - prevention & control</topic><topic>short chain galacto‐oligosaccharides (scGOS)</topic><topic>Synbiotics - administration & dosage</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sáez‐Fuertes, Laura</creatorcontrib><creatorcontrib>Rio‐Aige, Karla</creatorcontrib><creatorcontrib>Massot‐Cladera, Malén</creatorcontrib><creatorcontrib>Castell, Margarida</creatorcontrib><creatorcontrib>Knipping, Karen</creatorcontrib><creatorcontrib>Garssen, Johan</creatorcontrib><creatorcontrib>Bourdet‐Sicard, Raphaëlle</creatorcontrib><creatorcontrib>Rodríguez‐Lagunas, María José</creatorcontrib><creatorcontrib>Collado, María Carmen</creatorcontrib><creatorcontrib>Pérez‐Cano, Francisco José</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular nutrition & food research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sáez‐Fuertes, Laura</au><au>Rio‐Aige, Karla</au><au>Massot‐Cladera, Malén</au><au>Castell, Margarida</au><au>Knipping, Karen</au><au>Garssen, Johan</au><au>Bourdet‐Sicard, Raphaëlle</au><au>Rodríguez‐Lagunas, María José</au><au>Collado, María Carmen</au><au>Pérez‐Cano, Francisco José</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bifidobacterium breve M‐16 V and scGOS/lcFOS Supplementation to Dams Ameliorates Infant Rotavirus Infection in Early Life</atitle><jtitle>Molecular nutrition & food research</jtitle><addtitle>Mol Nutr Food Res</addtitle><date>2024-11</date><risdate>2024</risdate><volume>68</volume><issue>22</issue><spage>e2400377</spage><epage>n/a</epage><pages>e2400377-n/a</pages><issn>1613-4125</issn><issn>1613-4133</issn><eissn>1613-4133</eissn><abstract>The immune system of newborns is underdeveloped, leaving them susceptible to infections like rotavirus (RV). Despite vaccines, RV remains a leading cause of child mortality, especially in developing countries. Maternal immunity is transferred during pregnancy and breastfeeding to the offspring providing protection against RV infection. This study aims to explore how the maternal diet can enhance the newborn's ability to fight early infections. Pregnant rats received orally Bifidobacterium breve M‐16 V and short chain galacto‐oligosaccharides (scGOS)/long chain fructo‐oligosaccharides (lcFOS). At day 5 of life pups are infected with RV and at day 8, samples are collected for the infection analysis. Pups whose mothers received the synbiotic have lower RV infection severity. The levels of immunoglobulins (Ig) IgG2c and IgA are raised in pups' plasma and digested milk, respectively. Synbiotic supplementation improves intestinal maturation and increases gene expression of immune‐related genes. In conclusion, the administration of this synbiotic to gestating and lactating mothers ameliorates the incidence and severity of the pup's diarrhea caused by the RV infection by improving their immunity.
The graphical illustrates the impact of maternal synbiotic supplementation with Bifidobacterium breve M‐16V and a mixture of short‐chain galacto‐oligosaccharides (scGOS) and long‐chain fructooligosaccharides (lcFOS) during gestation and lactation on the offspring's response to rotavirus (RV) infection in early life. Following maternal supplementation, the offspring of the supplemented dams exhibited reduced severity and incidence of infection. Additionally, the immunoglobulin profile, intestinal functionality, and microbiota composition of the offspring were modulated as a result of the maternal supplementation</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>39468988</pmid><doi>10.1002/mnfr.202400377</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-7870-8250</orcidid><orcidid>https://orcid.org/0000-0002-6204-4864</orcidid><orcidid>https://orcid.org/0000-0002-5220-2793</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Molecular nutrition & food research, 2024-11, Vol.68 (22), p.e2400377-n/a |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Animals, Newborn Bifidobacterium breve Bifidobacterium breve M‐16V Breast feeding children Developing countries Diarrhea Diarrhea - prevention & control Dietary Supplements Female food research fructooligosaccharides galactooligosaccharides Gene expression Immune system Immunity Immunity (Disease) Immunoglobulin A Immunoglobulin A - blood Immunoglobulins infancy Infections intestines Juveniles LDCs long chain fructo‐oligosaccharides (lcFOS) maternal immunity maternal nutrition Milk mortality Neonates Offspring Oligosaccharides Oligosaccharides - administration & dosage Oligosaccharides - pharmacology Pregnancy Rats Rats, Sprague-Dawley Rotavirus Rotavirus - immunology Rotavirus Infections - immunology Rotavirus Infections - prevention & control short chain galacto‐oligosaccharides (scGOS) Synbiotics - administration & dosage Viruses |
| title | Bifidobacterium breve M‐16 V and scGOS/lcFOS Supplementation to Dams Ameliorates Infant Rotavirus Infection in Early Life |
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