Expression of a tetrodotoxin-sensitive Na+ current in cultured human retinal pigment epithelial cells

We observed a tetrodotoxin (TTX)-sensitive Na+ current in cultured fetal and adult cells of the human retinal pigment epithelium (RPE), but not in any freshly isolated fetal (n = 54) or adult (n = 47) cells, using the whole-cell version of the patch-clamp technique. A similar current was found in cu...

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Veröffentlicht in:	The Journal of physiology 1994-04, Vol.476 (2), p.187-196
Hauptverfasser:	Wen, R, Lui, G M, Steinberg, R H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Differentiation - drug effects Cell Differentiation - physiology Cell Membrane - drug effects Cells, Cultured Culture Media Electrophysiology Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Humans Macaca mulatta Melanins - metabolism Phenotype Pigment Epithelium of Eye - drug effects Pigment Epithelium of Eye - metabolism Pigment Epithelium of Eye - ultrastructure Sodium Channels - drug effects Sodium Channels - metabolism Tetrodotoxin - pharmacology Vertebrates: nervous system and sense organs
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