Association of Heterotopic Gastric Mucosa in the Upper Esophagus (HGMUE) with Pharyngolaryngeal Symptoms: A Systematic Review and Meta-Analysis
Background Heterotopic gastric mucosa in the upper esophagus (HGMUE) is considered to be accompanied by pharyngolaryngeal symptoms, whereas the association strength between HGMUE and pharyngolaryngeal symptoms remains controversial. This study assessed the strength of the association between HGMUE a...
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| Veröffentlicht in: | Digestive diseases and sciences 2024-12, Vol.69 (12), p.4416-4429 |
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| creator | Chen, Xuanran Zhou, Shunhai Shi, Chaoyi Feng, Mingzhi ZhuoMa, GeSang Shen, Diyun Wang, Tianyue Zhang, Jun |
| description | Background
Heterotopic gastric mucosa in the upper esophagus (HGMUE) is considered to be accompanied by pharyngolaryngeal symptoms, whereas the association strength between HGMUE and pharyngolaryngeal symptoms remains controversial. This study assessed the strength of the association between HGMUE and pharyngolaryngeal symptoms using a meta-analytic approach.
Methods
PubMed, Embase, Web of Science, and CNKI databases were searched for relevant articles published between January 2010 and January 2024. The pharyngolaryngeal symptoms of chronic cough, dysphagia, hoarseness, and globus in patients with HGMUE were summarized. The pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using a random-effects model. The exploratory analyses were also performed, including sensitivity and subgroup analyses.
Results
A total of 17 observational studies (1 cohort study and 16 cross-sectional studies) with 626,369 patients (2414 HGMUE patients and 623,955 non-HGMUE patients) were included in the meta-analysis. HGMUE was significantly associated with an elevated incidence of chronic cough (OR: 3.36; 95% CI 1.25–9.01;
P
= 0.02), dysphagia (OR: 1.58; 95% CI 1.12–2.25;
P
= 0.01), hoarseness (OR: 4.13; 95% CI 1.47–11.56;
P
= 0.007), and globus (OR: 2.41; 95% CI: 1.43–4.04,
P
|
| doi_str_mv | 10.1007/s10620-024-08699-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11602832</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3133626729</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-1e3473b8389d22b180fc5bca35188f99abb36b660b91663ecc84797f0cbb24b83</originalsourceid><addsrcrecordid>eNp9kctuEzEUhi0EoqHwAiyQJTZlMeDLjMdmg6IqTZAagYCsLdvxZFzNjKe2p1Gegleu25RyWbA6Rzrf-c_lB-A1Ru8xQvWHiBEjqECkLBBnQhT7J2CGq5oWpGL8KZghzHKOMTsBL2K8QgiJGrPn4ISKUlQlrmbg5zxGb5xKzg_QN3Blkw0--dEZuFQxhRzXk_FRQTfA1Fq4GUcb4CL6sVW7KcKz1XK9WbyDe5da-LVV4TDsfHcfrOrg90M_Jt_Hj3Ce85hsn2cZ-M3eOLuHatjCtU2qmA-qO0QXX4JnjeqiffUQT8HmYvHjfFVcfll-Pp9fFoZWLBXY0rKmmlMutoRozFFjKm0UrTDnjRBKa8o0Y0gLzBi1xvCyFnWDjNakzH2n4NNRd5x0b7fGDimoTo7B9Xl16ZWTf1cG18qdv5H5m4hwSrLC2YNC8NeTjUn2LhrbdWqwfoqSYkI5qkXFMvr2H_TKTyFffEdRygiricgUOVIm-BiDbR63wUjeGS6PhstsuLw3XO5z05s_73hs-eVwBugRiLmULQm_Z_9H9hY_RLje</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3133626729</pqid></control><display><type>article</type><title>Association of Heterotopic Gastric Mucosa in the Upper Esophagus (HGMUE) with Pharyngolaryngeal Symptoms: A Systematic Review and Meta-Analysis</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Chen, Xuanran ; Zhou, Shunhai ; Shi, Chaoyi ; Feng, Mingzhi ; ZhuoMa, GeSang ; Shen, Diyun ; Wang, Tianyue ; Zhang, Jun</creator><creatorcontrib>Chen, Xuanran ; Zhou, Shunhai ; Shi, Chaoyi ; Feng, Mingzhi ; ZhuoMa, GeSang ; Shen, Diyun ; Wang, Tianyue ; Zhang, Jun</creatorcontrib><description>Background
Heterotopic gastric mucosa in the upper esophagus (HGMUE) is considered to be accompanied by pharyngolaryngeal symptoms, whereas the association strength between HGMUE and pharyngolaryngeal symptoms remains controversial. This study assessed the strength of the association between HGMUE and pharyngolaryngeal symptoms using a meta-analytic approach.
Methods
PubMed, Embase, Web of Science, and CNKI databases were searched for relevant articles published between January 2010 and January 2024. The pharyngolaryngeal symptoms of chronic cough, dysphagia, hoarseness, and globus in patients with HGMUE were summarized. The pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using a random-effects model. The exploratory analyses were also performed, including sensitivity and subgroup analyses.
Results
A total of 17 observational studies (1 cohort study and 16 cross-sectional studies) with 626,369 patients (2414 HGMUE patients and 623,955 non-HGMUE patients) were included in the meta-analysis. HGMUE was significantly associated with an elevated incidence of chronic cough (OR: 3.36; 95% CI 1.25–9.01;
P
= 0.02), dysphagia (OR: 1.58; 95% CI 1.12–2.25;
P
= 0.01), hoarseness (OR: 4.13; 95% CI 1.47–11.56;
P
= 0.007), and globus (OR: 2.41; 95% CI: 1.43–4.04,
P
< 0.001). The association between HGMUE and the risk of dysphagia was found to be potentially influenced by study design, sample size, country, and diagnostic method, whereas the association between HGMUE with the risk of globus was potentially affected by the study design and country.
Conclusion
HGMUE was significantly associated with chronic cough, dysphagia, hoarseness, and globus. HGMUE should be taken into consideration for patients with pharyngolaryngeal symptoms.</description><identifier>ISSN: 0163-2116</identifier><identifier>ISSN: 1573-2568</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-024-08699-w</identifier><identifier>PMID: 39495415</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biochemistry ; Choristoma - complications ; Choristoma - diagnosis ; Choristoma - epidemiology ; Cough - epidemiology ; Cough - etiology ; Deglutition Disorders - epidemiology ; Deglutition Disorders - etiology ; Dysphagia ; Esophageal Diseases - diagnosis ; Esophageal Diseases - epidemiology ; Esophageal Diseases - etiology ; Esophagus ; Gastric Mucosa - pathology ; Gastroenterology ; Hepatology ; Hoarseness - epidemiology ; Hoarseness - etiology ; Humans ; Medicine ; Medicine & Public Health ; Meta-analysis ; Observational studies ; Oncology ; Original ; Original Article ; Pharyngeal Diseases - diagnosis ; Pharyngeal Diseases - epidemiology ; Pharyngeal Diseases - etiology ; Systematic review ; Transplant Surgery ; Whooping cough</subject><ispartof>Digestive diseases and sciences, 2024-12, Vol.69 (12), p.4416-4429</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2024 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c356t-1e3473b8389d22b180fc5bca35188f99abb36b660b91663ecc84797f0cbb24b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10620-024-08699-w$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10620-024-08699-w$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39495415$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Xuanran</creatorcontrib><creatorcontrib>Zhou, Shunhai</creatorcontrib><creatorcontrib>Shi, Chaoyi</creatorcontrib><creatorcontrib>Feng, Mingzhi</creatorcontrib><creatorcontrib>ZhuoMa, GeSang</creatorcontrib><creatorcontrib>Shen, Diyun</creatorcontrib><creatorcontrib>Wang, Tianyue</creatorcontrib><creatorcontrib>Zhang, Jun</creatorcontrib><title>Association of Heterotopic Gastric Mucosa in the Upper Esophagus (HGMUE) with Pharyngolaryngeal Symptoms: A Systematic Review and Meta-Analysis</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><addtitle>Dig Dis Sci</addtitle><description>Background
Heterotopic gastric mucosa in the upper esophagus (HGMUE) is considered to be accompanied by pharyngolaryngeal symptoms, whereas the association strength between HGMUE and pharyngolaryngeal symptoms remains controversial. This study assessed the strength of the association between HGMUE and pharyngolaryngeal symptoms using a meta-analytic approach.
Methods
PubMed, Embase, Web of Science, and CNKI databases were searched for relevant articles published between January 2010 and January 2024. The pharyngolaryngeal symptoms of chronic cough, dysphagia, hoarseness, and globus in patients with HGMUE were summarized. The pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using a random-effects model. The exploratory analyses were also performed, including sensitivity and subgroup analyses.
Results
A total of 17 observational studies (1 cohort study and 16 cross-sectional studies) with 626,369 patients (2414 HGMUE patients and 623,955 non-HGMUE patients) were included in the meta-analysis. HGMUE was significantly associated with an elevated incidence of chronic cough (OR: 3.36; 95% CI 1.25–9.01;
P
= 0.02), dysphagia (OR: 1.58; 95% CI 1.12–2.25;
P
= 0.01), hoarseness (OR: 4.13; 95% CI 1.47–11.56;
P
= 0.007), and globus (OR: 2.41; 95% CI: 1.43–4.04,
P
< 0.001). The association between HGMUE and the risk of dysphagia was found to be potentially influenced by study design, sample size, country, and diagnostic method, whereas the association between HGMUE with the risk of globus was potentially affected by the study design and country.
Conclusion
HGMUE was significantly associated with chronic cough, dysphagia, hoarseness, and globus. HGMUE should be taken into consideration for patients with pharyngolaryngeal symptoms.</description><subject>Biochemistry</subject><subject>Choristoma - complications</subject><subject>Choristoma - diagnosis</subject><subject>Choristoma - epidemiology</subject><subject>Cough - epidemiology</subject><subject>Cough - etiology</subject><subject>Deglutition Disorders - epidemiology</subject><subject>Deglutition Disorders - etiology</subject><subject>Dysphagia</subject><subject>Esophageal Diseases - diagnosis</subject><subject>Esophageal Diseases - epidemiology</subject><subject>Esophageal Diseases - etiology</subject><subject>Esophagus</subject><subject>Gastric Mucosa - pathology</subject><subject>Gastroenterology</subject><subject>Hepatology</subject><subject>Hoarseness - epidemiology</subject><subject>Hoarseness - etiology</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meta-analysis</subject><subject>Observational studies</subject><subject>Oncology</subject><subject>Original</subject><subject>Original Article</subject><subject>Pharyngeal Diseases - diagnosis</subject><subject>Pharyngeal Diseases - epidemiology</subject><subject>Pharyngeal Diseases - etiology</subject><subject>Systematic review</subject><subject>Transplant Surgery</subject><subject>Whooping cough</subject><issn>0163-2116</issn><issn>1573-2568</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kctuEzEUhi0EoqHwAiyQJTZlMeDLjMdmg6IqTZAagYCsLdvxZFzNjKe2p1Gegleu25RyWbA6Rzrf-c_lB-A1Ru8xQvWHiBEjqECkLBBnQhT7J2CGq5oWpGL8KZghzHKOMTsBL2K8QgiJGrPn4ISKUlQlrmbg5zxGb5xKzg_QN3Blkw0--dEZuFQxhRzXk_FRQTfA1Fq4GUcb4CL6sVW7KcKz1XK9WbyDe5da-LVV4TDsfHcfrOrg90M_Jt_Hj3Ce85hsn2cZ-M3eOLuHatjCtU2qmA-qO0QXX4JnjeqiffUQT8HmYvHjfFVcfll-Pp9fFoZWLBXY0rKmmlMutoRozFFjKm0UrTDnjRBKa8o0Y0gLzBi1xvCyFnWDjNakzH2n4NNRd5x0b7fGDimoTo7B9Xl16ZWTf1cG18qdv5H5m4hwSrLC2YNC8NeTjUn2LhrbdWqwfoqSYkI5qkXFMvr2H_TKTyFffEdRygiricgUOVIm-BiDbR63wUjeGS6PhstsuLw3XO5z05s_73hs-eVwBugRiLmULQm_Z_9H9hY_RLje</recordid><startdate>20241201</startdate><enddate>20241201</enddate><creator>Chen, Xuanran</creator><creator>Zhou, Shunhai</creator><creator>Shi, Chaoyi</creator><creator>Feng, Mingzhi</creator><creator>ZhuoMa, GeSang</creator><creator>Shen, Diyun</creator><creator>Wang, Tianyue</creator><creator>Zhang, Jun</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20241201</creationdate><title>Association of Heterotopic Gastric Mucosa in the Upper Esophagus (HGMUE) with Pharyngolaryngeal Symptoms: A Systematic Review and Meta-Analysis</title><author>Chen, Xuanran ; Zhou, Shunhai ; Shi, Chaoyi ; Feng, Mingzhi ; ZhuoMa, GeSang ; Shen, Diyun ; Wang, Tianyue ; Zhang, Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-1e3473b8389d22b180fc5bca35188f99abb36b660b91663ecc84797f0cbb24b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Biochemistry</topic><topic>Choristoma - complications</topic><topic>Choristoma - diagnosis</topic><topic>Choristoma - epidemiology</topic><topic>Cough - epidemiology</topic><topic>Cough - etiology</topic><topic>Deglutition Disorders - epidemiology</topic><topic>Deglutition Disorders - etiology</topic><topic>Dysphagia</topic><topic>Esophageal Diseases - diagnosis</topic><topic>Esophageal Diseases - epidemiology</topic><topic>Esophageal Diseases - etiology</topic><topic>Esophagus</topic><topic>Gastric Mucosa - pathology</topic><topic>Gastroenterology</topic><topic>Hepatology</topic><topic>Hoarseness - epidemiology</topic><topic>Hoarseness - etiology</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meta-analysis</topic><topic>Observational studies</topic><topic>Oncology</topic><topic>Original</topic><topic>Original Article</topic><topic>Pharyngeal Diseases - diagnosis</topic><topic>Pharyngeal Diseases - epidemiology</topic><topic>Pharyngeal Diseases - etiology</topic><topic>Systematic review</topic><topic>Transplant Surgery</topic><topic>Whooping cough</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Xuanran</creatorcontrib><creatorcontrib>Zhou, Shunhai</creatorcontrib><creatorcontrib>Shi, Chaoyi</creatorcontrib><creatorcontrib>Feng, Mingzhi</creatorcontrib><creatorcontrib>ZhuoMa, GeSang</creatorcontrib><creatorcontrib>Shen, Diyun</creatorcontrib><creatorcontrib>Wang, Tianyue</creatorcontrib><creatorcontrib>Zhang, Jun</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Xuanran</au><au>Zhou, Shunhai</au><au>Shi, Chaoyi</au><au>Feng, Mingzhi</au><au>ZhuoMa, GeSang</au><au>Shen, Diyun</au><au>Wang, Tianyue</au><au>Zhang, Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Heterotopic Gastric Mucosa in the Upper Esophagus (HGMUE) with Pharyngolaryngeal Symptoms: A Systematic Review and Meta-Analysis</atitle><jtitle>Digestive diseases and sciences</jtitle><stitle>Dig Dis Sci</stitle><addtitle>Dig Dis Sci</addtitle><date>2024-12-01</date><risdate>2024</risdate><volume>69</volume><issue>12</issue><spage>4416</spage><epage>4429</epage><pages>4416-4429</pages><issn>0163-2116</issn><issn>1573-2568</issn><eissn>1573-2568</eissn><abstract>Background
Heterotopic gastric mucosa in the upper esophagus (HGMUE) is considered to be accompanied by pharyngolaryngeal symptoms, whereas the association strength between HGMUE and pharyngolaryngeal symptoms remains controversial. This study assessed the strength of the association between HGMUE and pharyngolaryngeal symptoms using a meta-analytic approach.
Methods
PubMed, Embase, Web of Science, and CNKI databases were searched for relevant articles published between January 2010 and January 2024. The pharyngolaryngeal symptoms of chronic cough, dysphagia, hoarseness, and globus in patients with HGMUE were summarized. The pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using a random-effects model. The exploratory analyses were also performed, including sensitivity and subgroup analyses.
Results
A total of 17 observational studies (1 cohort study and 16 cross-sectional studies) with 626,369 patients (2414 HGMUE patients and 623,955 non-HGMUE patients) were included in the meta-analysis. HGMUE was significantly associated with an elevated incidence of chronic cough (OR: 3.36; 95% CI 1.25–9.01;
P
= 0.02), dysphagia (OR: 1.58; 95% CI 1.12–2.25;
P
= 0.01), hoarseness (OR: 4.13; 95% CI 1.47–11.56;
P
= 0.007), and globus (OR: 2.41; 95% CI: 1.43–4.04,
P
< 0.001). The association between HGMUE and the risk of dysphagia was found to be potentially influenced by study design, sample size, country, and diagnostic method, whereas the association between HGMUE with the risk of globus was potentially affected by the study design and country.
Conclusion
HGMUE was significantly associated with chronic cough, dysphagia, hoarseness, and globus. HGMUE should be taken into consideration for patients with pharyngolaryngeal symptoms.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>39495415</pmid><doi>10.1007/s10620-024-08699-w</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Biochemistry Choristoma - complications Choristoma - diagnosis Choristoma - epidemiology Cough - epidemiology Cough - etiology Deglutition Disorders - epidemiology Deglutition Disorders - etiology Dysphagia Esophageal Diseases - diagnosis Esophageal Diseases - epidemiology Esophageal Diseases - etiology Esophagus Gastric Mucosa - pathology Gastroenterology Hepatology Hoarseness - epidemiology Hoarseness - etiology Humans Medicine Medicine & Public Health Meta-analysis Observational studies Oncology Original Original Article Pharyngeal Diseases - diagnosis Pharyngeal Diseases - epidemiology Pharyngeal Diseases - etiology Systematic review Transplant Surgery Whooping cough |
| title | Association of Heterotopic Gastric Mucosa in the Upper Esophagus (HGMUE) with Pharyngolaryngeal Symptoms: A Systematic Review and Meta-Analysis |
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