CEP: a conformational epitope prediction server
CEP server (http://bioinfo.ernet.in/cep.htm) provides a web interface to the conformational epitope prediction algorithm developed in-house. The algorithm, apart from predicting conformational epitopes, also predicts antigenic determinants and sequential epitopes. The epitopes are predicted using 3D...
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| Veröffentlicht in: | Nucleic acids research 2005-07, Vol.33 (suppl-2), p.W168-W171 |
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| container_issue | suppl-2 |
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| container_title | Nucleic acids research |
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| creator | Kulkarni-Kale, Urmila Bhosle, Shriram Kolaskar, A. S. |
| description | CEP server (http://bioinfo.ernet.in/cep.htm) provides a web interface to the conformational epitope prediction algorithm developed in-house. The algorithm, apart from predicting conformational epitopes, also predicts antigenic determinants and sequential epitopes. The epitopes are predicted using 3D structure data of protein antigens, which can be visualized graphically. The algorithm employs structure-based Bioinformatics approach and solvent accessibility of amino acids in an explicit manner. Accuracy of the algorithm was found to be 75% when evaluated using X-ray crystal structures of Ag–Ab complexes available in the PDB. This is the first and the only method available for the prediction of conformational epitopes, which is an attempt to map probable antibody-binding sites of protein antigens. |
| doi_str_mv | 10.1093/nar/gki460 |
| format | Article |
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S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CEP: a conformational epitope prediction server</atitle><jtitle>Nucleic acids research</jtitle><addtitle>Nucl. Acids Res</addtitle><date>2005-07-01</date><risdate>2005</risdate><volume>33</volume><issue>suppl-2</issue><spage>W168</spage><epage>W171</epage><pages>W168-W171</pages><issn>0305-1048</issn><eissn>1362-4962</eissn><coden>NARHAD</coden><abstract>CEP server (http://bioinfo.ernet.in/cep.htm) provides a web interface to the conformational epitope prediction algorithm developed in-house. The algorithm, apart from predicting conformational epitopes, also predicts antigenic determinants and sequential epitopes. The epitopes are predicted using 3D structure data of protein antigens, which can be visualized graphically. The algorithm employs structure-based Bioinformatics approach and solvent accessibility of amino acids in an explicit manner. 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| fulltext | fulltext |
| identifier | ISSN: 0305-1048 |
| ispartof | Nucleic acids research, 2005-07, Vol.33 (suppl-2), p.W168-W171 |
| issn | 0305-1048 1362-4962 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Access via Oxford University Press (Open Access Collection); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Algorithms Epitope Mapping - methods Epitopes - chemistry Internet Protein Conformation Proteins - chemistry Proteins - immunology Software Software Design User-Computer Interface |
| title | CEP: a conformational epitope prediction server |
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