Recruitment of homodimeric proneural factors by conserved CAT-CAT E-boxes drives major epigenetic reconfiguration in cortical neurogenesis

Proneural factors of the basic helix-loop-helix family coordinate neurogenesis and neurodifferentiation. Among them, NEUROG2 and NEUROD2 subsequently act to specify neurons of the glutamatergic lineage. Disruption of these factors, their target genes and binding DNA motifs has been linked to various...

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Veröffentlicht in:Nucleic acids research 2024-11, Vol.52 (21), p.12895-12917
Hauptverfasser: de Martin, Xabier, Oliva, Baldomero, Santpere, Gabriel
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Sprache:eng
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