YTHDF1 loss in dendritic cells potentiates radiation-induced antitumor immunity via STING-dependent type I IFN production

The RNA N6-methyladenosine (m6A) reader YTHDF1 is implicated in cancer etiology and progression. We discovered that radiotherapy (RT) increased YTHDF1 expression in dendritic cells (DCs) of PBMCs from patients with cancer, but not in other immune cells tested. Elevated YTHDF1 expression in DCs was a...

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Veröffentlicht in:	The Journal of clinical investigation 2024-12, Vol.134 (23), p.1-13
Hauptverfasser:	Wen, Chuangyu, Wang, Liangliang, Piffkó, András, Chen, Dapeng, Yu, Xianbin, Zawieracz, Katarzyna, Bugno, Jason, Yang, Kaiting, Naccasha, Emile Z, Ji, Fei, Wang, Jiaai, Huang, Xiaona, Luo, Stephen Y, Tan, Lei, Shen, Bin, Luo, Cheng, McNerney, Megan E, Chmura, Steven J, Arina, Ainhoa, Pitroda, Sean, He, Chuan, Liang, Hua Laura, Weichselbaum, Ralph R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antigen presentation Antitumor activity Cancer therapies Care and treatment Cathepsins Dendritic cells Dendritic Cells - immunology Dendritic Cells - metabolism Female Flow cytometry Health aspects Humans Immunotherapy Interferon Interferon Type I - genetics Interferon Type I - immunology Interferon Type I - metabolism Ionizing radiation Lymphocytes Melanoma Melanoma, Experimental - genetics Melanoma, Experimental - immunology Melanoma, Experimental - metabolism Melanoma, Experimental - pathology Melanoma, Experimental - radiotherapy Membrane Proteins - genetics Membrane Proteins - immunology Membrane Proteins - metabolism Metastasis Methods Mice Mice, Knockout Physiological aspects Proteins Radiation therapy Radioimmunotherapy RNA-Binding Proteins - genetics RNA-Binding Proteins - immunology RNA-Binding Proteins - metabolism Tumors Vaccines
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