Identification of VISTA regulators in macrophages mediating cancer cell survival

Numerous human cancers have exhibited the ability to elude immune checkpoint blockade (ICB) therapies. This type of resistance can be mediated by immune-suppressive macrophages that limit antitumor immunity in the tumor microenvironment (TME). Here, we elucidate a strategy to shift macrophages into...

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Veröffentlicht in:	Science advances 2024-11, Vol.10 (48), p.eadq8122
Hauptverfasser:	Abdrabou, Abdalla M, Ahmed, Sharif U, Fan, Mengqi Jonathan, Duong, Bill T V, Chen, Kangfu, Lo, Pei-Ying, Mayes, Julia M, Esmaeili, Fatemeh, GhavamiNejad, Amin, Zargartalebi, Hossein, Atwal, Randy Singh, Lin, Sichun, Angers, Stephane, Kelley, Shana O
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B7 Antigens - genetics B7 Antigens - metabolism Biomedicine and Life Sciences Cancer Cell Line, Tumor Cell Survival Humans Immune Checkpoint Inhibitors - pharmacology Interleukin-1 Receptor-Associated Kinases - genetics Interleukin-1 Receptor-Associated Kinases - metabolism Macrophages - immunology Macrophages - metabolism Membrane Proteins Mice Molecular Biology Neoplasms - genetics Neoplasms - immunology Neoplasms - metabolism Neoplasms - pathology SciAdv r-articles Tumor Microenvironment - immunology
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