Different roles for GABAA and GABAB receptors in visual processing in the rat superior colliculus
1. The superficial grey layer of the superior colliculus (SGS) contains a high proportion of GABAergic inhibitory neurones. We have investigated the role of GABA receptors in synaptic transmission of aspects of visual activity in the SGS that may be driven by inhibitory mechanisms, such as surround...
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| description | 1. The superficial grey layer of the superior colliculus (SGS) contains a high proportion of GABAergic inhibitory neurones.
We have investigated the role of GABA receptors in synaptic transmission of aspects of visual activity in the SGS that may
be driven by inhibitory mechanisms, such as surround inhibition and response habituation. 2. Multi-barrel glass iontophoretic
pipettes were used to record single neuronal activity in the SGS of urethane-anaesthetized rats. Visual stimulation was provided
by the display of moving bars and stationary spots of light on a monitor placed in the receptive field. 3. Both ejection of
GABA and the GABAB agonist baclofen reduced responses to moving bars (interstimulus intervals > or = 8 s). The effects of
GABA were reversed by the GABAA antagonist bicuculline, and the effects of baclofen were antagonized by the GABAB antagonist
CGP 35,348. 4. Surround inhibition was estimated by plotting the response to flashed spots of increasing diameter. In controls,
expanding the spot diameter beyond the excitatory receptive field caused a decrease in the response. This inhibitory surround
was reversibly reduced by bicuculline, but CGP 35,348 had no effect. 5. Response habituation is the progressive reduction
in the visual response during repetitive stimulus presentation. In controls, the visual response was reduced to 44 +/- 3%
of its initial level when a stimulus (moving bar) was presented 5 times with an interstimulus interval of 0.5 s. During CGP
35,348 ejection, response habituation was reversibly reduced. Bicuculline had no effect on response habituation. 6. The effects
of bicuculline on surround inhibition in the superior colliculus are consistent with similar studies in the lateral geniculate
nucleus which indicate that GABAA receptors mediate this effect. The function of GABAB receptors in the visual system is less
well researched. The reduction of response habituation with CGP 35,348 demonstrates that, at least in the SGS, GABAB receptors
have an important role in visual transmission which is distinct from that of GABAA receptors. |
| doi_str_mv | 10.1111/j.1469-7793.1997.629bd.x |
| format | Article |
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We have investigated the role of GABA receptors in synaptic transmission of aspects of visual activity in the SGS that may
be driven by inhibitory mechanisms, such as surround inhibition and response habituation. 2. Multi-barrel glass iontophoretic
pipettes were used to record single neuronal activity in the SGS of urethane-anaesthetized rats. Visual stimulation was provided
by the display of moving bars and stationary spots of light on a monitor placed in the receptive field. 3. Both ejection of
GABA and the GABAB agonist baclofen reduced responses to moving bars (interstimulus intervals > or = 8 s). The effects of
GABA were reversed by the GABAA antagonist bicuculline, and the effects of baclofen were antagonized by the GABAB antagonist
CGP 35,348. 4. Surround inhibition was estimated by plotting the response to flashed spots of increasing diameter. In controls,
expanding the spot diameter beyond the excitatory receptive field caused a decrease in the response. This inhibitory surround
was reversibly reduced by bicuculline, but CGP 35,348 had no effect. 5. Response habituation is the progressive reduction
in the visual response during repetitive stimulus presentation. In controls, the visual response was reduced to 44 +/- 3%
of its initial level when a stimulus (moving bar) was presented 5 times with an interstimulus interval of 0.5 s. During CGP
35,348 ejection, response habituation was reversibly reduced. Bicuculline had no effect on response habituation. 6. The effects
of bicuculline on surround inhibition in the superior colliculus are consistent with similar studies in the lateral geniculate
nucleus which indicate that GABAA receptors mediate this effect. The function of GABAB receptors in the visual system is less
well researched. The reduction of response habituation with CGP 35,348 demonstrates that, at least in the SGS, GABAB receptors
have an important role in visual transmission which is distinct from that of GABAA receptors.</description><identifier>ISSN: 0022-3751</identifier><identifier>EISSN: 1469-7793</identifier><identifier>DOI: 10.1111/j.1469-7793.1997.629bd.x</identifier><identifier>PMID: 9401970</identifier><language>eng</language><publisher>Oxford, UK: The Physiological Society</publisher><subject>Animals ; Baclofen - pharmacology ; Bicuculline - pharmacology ; GABA Agonists - pharmacology ; GABA-A Receptor Agonists ; GABA-A Receptor Antagonists ; GABA-B Receptor Agonists ; GABA-B Receptor Antagonists ; gamma-Aminobutyric Acid - pharmacology ; Habituation, Psychophysiologic - drug effects ; Iontophoresis ; Organophosphorus Compounds - pharmacology ; Photic Stimulation ; Rats ; Receptors, GABA-A - drug effects ; Receptors, GABA-B - drug effects ; Superior Colliculi - drug effects ; Superior Colliculi - physiology ; Vision, Ocular - drug effects ; Vision, Ocular - physiology ; Visual Fields - physiology</subject><ispartof>The Journal of physiology, 1997-11, Vol.504 (Pt 3), p.629-639</ispartof><rights>1997 The Physiological Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1159966/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1159966/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,1418,1434,27929,27930,45579,45580,46414,46838,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9401970$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Binns, K. E.</creatorcontrib><creatorcontrib>Salt, T. E.</creatorcontrib><title>Different roles for GABAA and GABAB receptors in visual processing in the rat superior colliculus</title><title>The Journal of physiology</title><addtitle>J Physiol</addtitle><description>1. The superficial grey layer of the superior colliculus (SGS) contains a high proportion of GABAergic inhibitory neurones.
We have investigated the role of GABA receptors in synaptic transmission of aspects of visual activity in the SGS that may
be driven by inhibitory mechanisms, such as surround inhibition and response habituation. 2. Multi-barrel glass iontophoretic
pipettes were used to record single neuronal activity in the SGS of urethane-anaesthetized rats. Visual stimulation was provided
by the display of moving bars and stationary spots of light on a monitor placed in the receptive field. 3. Both ejection of
GABA and the GABAB agonist baclofen reduced responses to moving bars (interstimulus intervals > or = 8 s). The effects of
GABA were reversed by the GABAA antagonist bicuculline, and the effects of baclofen were antagonized by the GABAB antagonist
CGP 35,348. 4. Surround inhibition was estimated by plotting the response to flashed spots of increasing diameter. In controls,
expanding the spot diameter beyond the excitatory receptive field caused a decrease in the response. This inhibitory surround
was reversibly reduced by bicuculline, but CGP 35,348 had no effect. 5. Response habituation is the progressive reduction
in the visual response during repetitive stimulus presentation. In controls, the visual response was reduced to 44 +/- 3%
of its initial level when a stimulus (moving bar) was presented 5 times with an interstimulus interval of 0.5 s. During CGP
35,348 ejection, response habituation was reversibly reduced. Bicuculline had no effect on response habituation. 6. The effects
of bicuculline on surround inhibition in the superior colliculus are consistent with similar studies in the lateral geniculate
nucleus which indicate that GABAA receptors mediate this effect. The function of GABAB receptors in the visual system is less
well researched. The reduction of response habituation with CGP 35,348 demonstrates that, at least in the SGS, GABAB receptors
have an important role in visual transmission which is distinct from that of GABAA receptors.</description><subject>Animals</subject><subject>Baclofen - pharmacology</subject><subject>Bicuculline - pharmacology</subject><subject>GABA Agonists - pharmacology</subject><subject>GABA-A Receptor Agonists</subject><subject>GABA-A Receptor Antagonists</subject><subject>GABA-B Receptor Agonists</subject><subject>GABA-B Receptor Antagonists</subject><subject>gamma-Aminobutyric Acid - pharmacology</subject><subject>Habituation, Psychophysiologic - drug effects</subject><subject>Iontophoresis</subject><subject>Organophosphorus Compounds - pharmacology</subject><subject>Photic Stimulation</subject><subject>Rats</subject><subject>Receptors, GABA-A - drug effects</subject><subject>Receptors, GABA-B - drug effects</subject><subject>Superior Colliculi - drug effects</subject><subject>Superior Colliculi - physiology</subject><subject>Vision, Ocular - drug effects</subject><subject>Vision, Ocular - physiology</subject><subject>Visual Fields - physiology</subject><issn>0022-3751</issn><issn>1469-7793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUFr3DAQhUVpSTdpf0JBpx4KdiTLa1lQCpukSRoCySE9D5I9XmvRWq5kJ9l_Xzu7LK0uGubTeyPpEUI5S_m0zjcpzwuVSKlEypWSaZEpU6ev78jiCN6TBWNZlgi55B_JaYwbxrhgSp2QE5UzriRbEH1lmwYDdgMN3mGkjQ_0ZnWxWlHd1W_VBQ1YYT_4EKnt6LONo3a0D77CGG23nptDizTogcaxx2Ani8o7Z6vRjfET-dBoF_HzYT8jv69_Pl3eJvcPN78uV_dJK6ZLJSWWsjBlxnKBVdYohcY0RmWlFDxDLrVsaqZFIXIh0GCtFDNGllWTSYP50ogz8mPv249mi3U1PSloB32wWx124LWF_0lnW1j7Z-B8qVRRTAZfDwbB_xkxDrC1sULndId-jCBVLjkv1HTwy7-TjiMOnzrx73v-Yh3ujpgzmLODDcwRwRwRzNnBW3bwCk93j1M5yb_t5a1dty82IPTtLloffWVx2MGS5fA4gJh14i-Ntp6P</recordid><startdate>19971101</startdate><enddate>19971101</enddate><creator>Binns, K. E.</creator><creator>Salt, T. E.</creator><general>The Physiological Society</general><general>Blackwell Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19971101</creationdate><title>Different roles for GABAA and GABAB receptors in visual processing in the rat superior colliculus</title><author>Binns, K. E. ; Salt, T. E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h3309-8e876b82043ec2f99ebbfb9287312e17a7fd0a363433ebed990bb78cf27be45b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Baclofen - pharmacology</topic><topic>Bicuculline - pharmacology</topic><topic>GABA Agonists - pharmacology</topic><topic>GABA-A Receptor Agonists</topic><topic>GABA-A Receptor Antagonists</topic><topic>GABA-B Receptor Agonists</topic><topic>GABA-B Receptor Antagonists</topic><topic>gamma-Aminobutyric Acid - pharmacology</topic><topic>Habituation, Psychophysiologic - drug effects</topic><topic>Iontophoresis</topic><topic>Organophosphorus Compounds - pharmacology</topic><topic>Photic Stimulation</topic><topic>Rats</topic><topic>Receptors, GABA-A - drug effects</topic><topic>Receptors, GABA-B - drug effects</topic><topic>Superior Colliculi - drug effects</topic><topic>Superior Colliculi - physiology</topic><topic>Vision, Ocular - drug effects</topic><topic>Vision, Ocular - physiology</topic><topic>Visual Fields - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Binns, K. E.</creatorcontrib><creatorcontrib>Salt, T. E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Binns, K. E.</au><au>Salt, T. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Different roles for GABAA and GABAB receptors in visual processing in the rat superior colliculus</atitle><jtitle>The Journal of physiology</jtitle><addtitle>J Physiol</addtitle><date>1997-11-01</date><risdate>1997</risdate><volume>504</volume><issue>Pt 3</issue><spage>629</spage><epage>639</epage><pages>629-639</pages><issn>0022-3751</issn><eissn>1469-7793</eissn><abstract>1. The superficial grey layer of the superior colliculus (SGS) contains a high proportion of GABAergic inhibitory neurones.
We have investigated the role of GABA receptors in synaptic transmission of aspects of visual activity in the SGS that may
be driven by inhibitory mechanisms, such as surround inhibition and response habituation. 2. Multi-barrel glass iontophoretic
pipettes were used to record single neuronal activity in the SGS of urethane-anaesthetized rats. Visual stimulation was provided
by the display of moving bars and stationary spots of light on a monitor placed in the receptive field. 3. Both ejection of
GABA and the GABAB agonist baclofen reduced responses to moving bars (interstimulus intervals > or = 8 s). The effects of
GABA were reversed by the GABAA antagonist bicuculline, and the effects of baclofen were antagonized by the GABAB antagonist
CGP 35,348. 4. Surround inhibition was estimated by plotting the response to flashed spots of increasing diameter. In controls,
expanding the spot diameter beyond the excitatory receptive field caused a decrease in the response. This inhibitory surround
was reversibly reduced by bicuculline, but CGP 35,348 had no effect. 5. Response habituation is the progressive reduction
in the visual response during repetitive stimulus presentation. In controls, the visual response was reduced to 44 +/- 3%
of its initial level when a stimulus (moving bar) was presented 5 times with an interstimulus interval of 0.5 s. During CGP
35,348 ejection, response habituation was reversibly reduced. Bicuculline had no effect on response habituation. 6. The effects
of bicuculline on surround inhibition in the superior colliculus are consistent with similar studies in the lateral geniculate
nucleus which indicate that GABAA receptors mediate this effect. The function of GABAB receptors in the visual system is less
well researched. The reduction of response habituation with CGP 35,348 demonstrates that, at least in the SGS, GABAB receptors
have an important role in visual transmission which is distinct from that of GABAA receptors.</abstract><cop>Oxford, UK</cop><pub>The Physiological Society</pub><pmid>9401970</pmid><doi>10.1111/j.1469-7793.1997.629bd.x</doi><tpages>11</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content; IngentaConnect Free/Open Access Journals; Wiley Online Library All Journals; PubMed Central |
| subjects | Animals Baclofen - pharmacology Bicuculline - pharmacology GABA Agonists - pharmacology GABA-A Receptor Agonists GABA-A Receptor Antagonists GABA-B Receptor Agonists GABA-B Receptor Antagonists gamma-Aminobutyric Acid - pharmacology Habituation, Psychophysiologic - drug effects Iontophoresis Organophosphorus Compounds - pharmacology Photic Stimulation Rats Receptors, GABA-A - drug effects Receptors, GABA-B - drug effects Superior Colliculi - drug effects Superior Colliculi - physiology Vision, Ocular - drug effects Vision, Ocular - physiology Visual Fields - physiology |
| title | Different roles for GABAA and GABAB receptors in visual processing in the rat superior colliculus |
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