High Doses of Vitamin D and Specific Metabolic Parameters in Type 2 Diabetes Patients: Systematic Review
Type II diabetes mellitus (T2DM) is recognized as a condition of mild chronic inflammation, marked by increased levels of acute-phase proteins and various inflammatory indicators. These inflammatory substances, along with inflammation of adipose tissue and the secretion of adipocytokines, can contri...
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| Veröffentlicht in: | Nutrients 2024-11, Vol.16 (22), p.3903 |
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| description | Type II diabetes mellitus (T2DM) is recognized as a condition of mild chronic inflammation, marked by increased levels of acute-phase proteins and various inflammatory indicators. These inflammatory substances, along with inflammation of adipose tissue and the secretion of adipocytokines, can contribute to insulin resistance and β cell dysfunction. By influencing both innate and adaptive immunity, vitamin D can inhibit the production of inflammatory cytokines and help mitigate the low-grade chronic inflammation associated with T2DM. Several strategies have been proposed to increase vitamin D levels effectively and safely, but the recent and strong ones have common tactics. Short-term high doses increase the level acutely, and long-term lower doses maintain sufficient levels.
The aim of our work was to determine and verify the effectiveness of high doses of vitamin D to safely increase its level in patients with type 2 diabetes mellitus, as well as the effect of these doses on selected metabolic parameters. Data from 20 studies (vitamin D group
= 612, and control group
= 592) regarding the influence of vitamin D supplementation with doses above 4000 IU on serum 25(OH)D, fasting blood glucose (FBG), hemoglobin A1c (HbA1c), blood pressure, serum calcium, and parathormone were pooled.
Vitamin D supplementation significantly improved serum 25(OH)D levels, with an average increase after intervention versus baseline at 177.09%. Our studies suggest that vitamin D supplementation may benefit various parameters in T2DM patients, including glycemic control, blood pressure, and PTH levels.
Vitamin D supplementation may have beneficial effects on various parameters in type 2 diabetes patients, including glycemic control, blood pressure, and parathormone levels. However, the results are only sometimes consistent across all studies. Further examination is needed. |
| doi_str_mv | 10.3390/nu16223903 |
| format | Article |
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The aim of our work was to determine and verify the effectiveness of high doses of vitamin D to safely increase its level in patients with type 2 diabetes mellitus, as well as the effect of these doses on selected metabolic parameters. Data from 20 studies (vitamin D group
= 612, and control group
= 592) regarding the influence of vitamin D supplementation with doses above 4000 IU on serum 25(OH)D, fasting blood glucose (FBG), hemoglobin A1c (HbA1c), blood pressure, serum calcium, and parathormone were pooled.
Vitamin D supplementation significantly improved serum 25(OH)D levels, with an average increase after intervention versus baseline at 177.09%. Our studies suggest that vitamin D supplementation may benefit various parameters in T2DM patients, including glycemic control, blood pressure, and PTH levels.
Vitamin D supplementation may have beneficial effects on various parameters in type 2 diabetes patients, including glycemic control, blood pressure, and parathormone levels. However, the results are only sometimes consistent across all studies. Further examination is needed.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu16223903</identifier><identifier>PMID: 39599690</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adaptive immunity ; Adipose tissues ; Alfacalcidol ; Antimicrobial agents ; B cells ; Blood Glucose - metabolism ; Blood pressure ; Blood Pressure - drug effects ; Blood sugar ; Calcifediol ; Calcium - blood ; Clinical trials ; Cytokines ; Diabetes ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - drug therapy ; Diet therapy ; Dietary Supplements ; Female ; Genes ; Glycated Hemoglobin - metabolism ; Glycosylated hemoglobin ; Homeostasis ; Humans ; Immune system ; Immunity (Disease) ; Immunoglobulins ; Inflammation ; Insulin resistance ; Lymphocytes ; Male ; Medical research ; Metabolism ; Metabolites ; Middle Aged ; Parathyroid hormone ; Parathyroid Hormone - blood ; Proteins ; Systematic Review ; Tumor necrosis factor-TNF ; Type 2 diabetes ; Vitamin D ; Vitamin D - administration & dosage ; Vitamin D - blood ; Vitamin deficiency</subject><ispartof>Nutrients, 2024-11, Vol.16 (22), p.3903</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c327t-c652384763a220bd3a6d27ebf1ad1db6b2a507e5596f129292f199011da728903</cites><orcidid>0000-0001-9208-5352 ; 0000-0002-1348-3721 ; 0000-0002-9506-4773 ; 0000-0002-0023-4574 ; 0000-0002-4515-5693</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11597282/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11597282/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39599690$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Max, Filip</creatorcontrib><creatorcontrib>Gažová, Andrea</creatorcontrib><creatorcontrib>Smaha, Juraj</creatorcontrib><creatorcontrib>Jankovský, Martin</creatorcontrib><creatorcontrib>Tesař, Tomáš</creatorcontrib><creatorcontrib>Jackuliak, Peter</creatorcontrib><creatorcontrib>Kužma, Martin</creatorcontrib><creatorcontrib>Payer, Juraj</creatorcontrib><creatorcontrib>Kyselovič, Ján</creatorcontrib><title>High Doses of Vitamin D and Specific Metabolic Parameters in Type 2 Diabetes Patients: Systematic Review</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Type II diabetes mellitus (T2DM) is recognized as a condition of mild chronic inflammation, marked by increased levels of acute-phase proteins and various inflammatory indicators. These inflammatory substances, along with inflammation of adipose tissue and the secretion of adipocytokines, can contribute to insulin resistance and β cell dysfunction. By influencing both innate and adaptive immunity, vitamin D can inhibit the production of inflammatory cytokines and help mitigate the low-grade chronic inflammation associated with T2DM. Several strategies have been proposed to increase vitamin D levels effectively and safely, but the recent and strong ones have common tactics. Short-term high doses increase the level acutely, and long-term lower doses maintain sufficient levels.
The aim of our work was to determine and verify the effectiveness of high doses of vitamin D to safely increase its level in patients with type 2 diabetes mellitus, as well as the effect of these doses on selected metabolic parameters. Data from 20 studies (vitamin D group
= 612, and control group
= 592) regarding the influence of vitamin D supplementation with doses above 4000 IU on serum 25(OH)D, fasting blood glucose (FBG), hemoglobin A1c (HbA1c), blood pressure, serum calcium, and parathormone were pooled.
Vitamin D supplementation significantly improved serum 25(OH)D levels, with an average increase after intervention versus baseline at 177.09%. Our studies suggest that vitamin D supplementation may benefit various parameters in T2DM patients, including glycemic control, blood pressure, and PTH levels.
Vitamin D supplementation may have beneficial effects on various parameters in type 2 diabetes patients, including glycemic control, blood pressure, and parathormone levels. However, the results are only sometimes consistent across all studies. Further examination is needed.</description><subject>Adaptive immunity</subject><subject>Adipose tissues</subject><subject>Alfacalcidol</subject><subject>Antimicrobial agents</subject><subject>B cells</subject><subject>Blood Glucose - metabolism</subject><subject>Blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Blood sugar</subject><subject>Calcifediol</subject><subject>Calcium - blood</subject><subject>Clinical trials</subject><subject>Cytokines</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Diet therapy</subject><subject>Dietary Supplements</subject><subject>Female</subject><subject>Genes</subject><subject>Glycated Hemoglobin - metabolism</subject><subject>Glycosylated hemoglobin</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunity (Disease)</subject><subject>Immunoglobulins</subject><subject>Inflammation</subject><subject>Insulin resistance</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Medical research</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Middle Aged</subject><subject>Parathyroid hormone</subject><subject>Parathyroid Hormone - blood</subject><subject>Proteins</subject><subject>Systematic Review</subject><subject>Tumor necrosis factor-TNF</subject><subject>Type 2 diabetes</subject><subject>Vitamin D</subject><subject>Vitamin D - administration & dosage</subject><subject>Vitamin D - blood</subject><subject>Vitamin deficiency</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptkt9PFDEQxxujEQK8-AeYJr4Yk4P-uG2vvhjCiZhANIK-Nt3u7F3Jbnu2u5j775mDE8HQeei085lvZ5oh5A1nh1IadhRHroRAT74gu4JpMVFqKl8-8nfIQSnXbLM000q-JjvSVMYow3bJ8iwslnSeChSaWvorDK4Pkc6piw29XIEPbfD0AgZXpw697y67HgbIhSJ2tV4BFXQeXI13BaNDgDiUj_RyXQbo8ejpD7gJ8GefvGpdV-Bgu--Rn6efr07OJuffvnw9OT6feCn0MPGqEnI2xTKdEKxupFON0FC33DW8qVUtXMU0VJVRLRcGreXGMM4bp8UMf2GPfLrXXY11D43HcrLr7CqH3uW1TS7Yp5EYlnaRbiznlUEJgQrvtwo5_R6hDLYPxUPXuQhpLFZyKaeKSS0Rffcfep3GHLG_O0owxe4Et9TCdWBDbBM-7Dei9njGZ1OlRaWROnyGQmugDz5FaAPeP0n4cJ_gcyolQ_vQJGd2Mxv232wg_PbxtzygfydB3gIN1bEN</recordid><startdate>20241115</startdate><enddate>20241115</enddate><creator>Max, Filip</creator><creator>Gažová, Andrea</creator><creator>Smaha, Juraj</creator><creator>Jankovský, Martin</creator><creator>Tesař, Tomáš</creator><creator>Jackuliak, Peter</creator><creator>Kužma, Martin</creator><creator>Payer, Juraj</creator><creator>Kyselovič, Ján</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9208-5352</orcidid><orcidid>https://orcid.org/0000-0002-1348-3721</orcidid><orcidid>https://orcid.org/0000-0002-9506-4773</orcidid><orcidid>https://orcid.org/0000-0002-0023-4574</orcidid><orcidid>https://orcid.org/0000-0002-4515-5693</orcidid></search><sort><creationdate>20241115</creationdate><title>High Doses of Vitamin D and Specific Metabolic Parameters in Type 2 Diabetes Patients: Systematic Review</title><author>Max, Filip ; 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These inflammatory substances, along with inflammation of adipose tissue and the secretion of adipocytokines, can contribute to insulin resistance and β cell dysfunction. By influencing both innate and adaptive immunity, vitamin D can inhibit the production of inflammatory cytokines and help mitigate the low-grade chronic inflammation associated with T2DM. Several strategies have been proposed to increase vitamin D levels effectively and safely, but the recent and strong ones have common tactics. Short-term high doses increase the level acutely, and long-term lower doses maintain sufficient levels.
The aim of our work was to determine and verify the effectiveness of high doses of vitamin D to safely increase its level in patients with type 2 diabetes mellitus, as well as the effect of these doses on selected metabolic parameters. Data from 20 studies (vitamin D group
= 612, and control group
= 592) regarding the influence of vitamin D supplementation with doses above 4000 IU on serum 25(OH)D, fasting blood glucose (FBG), hemoglobin A1c (HbA1c), blood pressure, serum calcium, and parathormone were pooled.
Vitamin D supplementation significantly improved serum 25(OH)D levels, with an average increase after intervention versus baseline at 177.09%. Our studies suggest that vitamin D supplementation may benefit various parameters in T2DM patients, including glycemic control, blood pressure, and PTH levels.
Vitamin D supplementation may have beneficial effects on various parameters in type 2 diabetes patients, including glycemic control, blood pressure, and parathormone levels. However, the results are only sometimes consistent across all studies. Further examination is needed.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39599690</pmid><doi>10.3390/nu16223903</doi><orcidid>https://orcid.org/0000-0001-9208-5352</orcidid><orcidid>https://orcid.org/0000-0002-1348-3721</orcidid><orcidid>https://orcid.org/0000-0002-9506-4773</orcidid><orcidid>https://orcid.org/0000-0002-0023-4574</orcidid><orcidid>https://orcid.org/0000-0002-4515-5693</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Adaptive immunity Adipose tissues Alfacalcidol Antimicrobial agents B cells Blood Glucose - metabolism Blood pressure Blood Pressure - drug effects Blood sugar Calcifediol Calcium - blood Clinical trials Cytokines Diabetes Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Diet therapy Dietary Supplements Female Genes Glycated Hemoglobin - metabolism Glycosylated hemoglobin Homeostasis Humans Immune system Immunity (Disease) Immunoglobulins Inflammation Insulin resistance Lymphocytes Male Medical research Metabolism Metabolites Middle Aged Parathyroid hormone Parathyroid Hormone - blood Proteins Systematic Review Tumor necrosis factor-TNF Type 2 diabetes Vitamin D Vitamin D - administration & dosage Vitamin D - blood Vitamin deficiency |
| title | High Doses of Vitamin D and Specific Metabolic Parameters in Type 2 Diabetes Patients: Systematic Review |
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