Normal Pressure Hydrocephalus in Adult Mice Causes Gait Impairment, Cognitive Deficits, and Urinary Frequency with Incontinence

Normal pressure hydrocephalus (NPH) is marked by enlarged cerebral ventricles with normal intracranial pressure, plus three stereotypical symptoms: gait impairment, cognitive dysfunction, and urinary frequency with urge incontinence. The neural circuit dysfunction responsible for each of these sympt...

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Veröffentlicht in:	eNeuro 2024-11, Vol.11 (11), p.ENEURO.0412-24.2024
Hauptverfasser:	Tish, Margaret M, Voss, Natalie A, Bertolli, Aimee X, Klimara, Miles J, Smith, Richard J, Thedens, Daniel R, Allamargot, Chantal, Hefti, Marco M, Howard, Matthew A, Aldridge, Georgina M, Geerling, Joel C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cognitive Dysfunction - etiology Cognitive Dysfunction - physiopathology Disease Models, Animal Female Gait Disorders, Neurologic - etiology Gait Disorders, Neurologic - physiopathology Hydrocephalus, Normal Pressure - complications Hydrocephalus, Normal Pressure - physiopathology Male Mice Mice, Inbred C57BL New Research Urinary Incontinence - physiopathology
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