Pregnancy-Related Precancerous Cervical Lesions: Pathogenesis, Diagnosis, Evolution, and Impact upon Gestation and Fertility
More common than cervical cancer, cervical intraepithelial neoplasia (CIN) represents a precursor lesion of cervical carcinoma, being associated with HPV infection. Due to the bidirectional relationship between HPV and estrogen and progesterone in pregnancy, most of the published data claim that pre...
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| Veröffentlicht in: | Journal of clinical medicine 2024-11, Vol.13 (22), p.6718 |
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| creator | Balan, Teodora Ana Balan, Raluca Anca Socolov, Demetra Gheorghiță, Vlad Radu Buțureanu, Tudor Andrei Păvăleanu, Ioana Coșovanu, Elena Teona Căruntu, Irina-Draga |
| description | More common than cervical cancer, cervical intraepithelial neoplasia (CIN) represents a precursor lesion of cervical carcinoma, being associated with HPV infection. Due to the bidirectional relationship between HPV and estrogen and progesterone in pregnancy, most of the published data claim that precancerous lesions remain stable or even regress during pregnancy, although several studies have indicated the tendency of HSILs to persist. It is considered that pregnancy-related cervical precancerous lesions undergo a postpartum regression, due to stimulatory effects of the immune microenvironment. Due to the rarity of publications on this subject, we aimed to offer a concise overview of and new insights into the current knowledge regarding the pathogenesis, diagnosis, and evolution of pregnancy-associated precancerous lesions, as well as their impact upon gestation and fertility. |
| doi_str_mv | 10.3390/jcm13226718 |
| format | Article |
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Due to the bidirectional relationship between HPV and estrogen and progesterone in pregnancy, most of the published data claim that precancerous lesions remain stable or even regress during pregnancy, although several studies have indicated the tendency of HSILs to persist. It is considered that pregnancy-related cervical precancerous lesions undergo a postpartum regression, due to stimulatory effects of the immune microenvironment. Due to the rarity of publications on this subject, we aimed to offer a concise overview of and new insights into the current knowledge regarding the pathogenesis, diagnosis, and evolution of pregnancy-associated precancerous lesions, as well as their impact upon gestation and fertility.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm13226718</identifier><identifier>PMID: 39597862</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Care and treatment ; Cellular biology ; Cervical cancer ; Cervix ; Complications and side effects ; Diagnosis ; Estrogens ; Fertility ; Hormones ; Human papillomavirus ; Immune system ; Immunology ; Infections ; Medical screening ; Microbiota ; Pap smear ; Pathogenesis ; Physiology ; Postpartum period ; Pregnancy ; Pregnancy, Complications of ; Review ; Risk factors ; Vagina ; Womens health</subject><ispartof>Journal of clinical medicine, 2024-11, Vol.13 (22), p.6718</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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Due to the bidirectional relationship between HPV and estrogen and progesterone in pregnancy, most of the published data claim that precancerous lesions remain stable or even regress during pregnancy, although several studies have indicated the tendency of HSILs to persist. It is considered that pregnancy-related cervical precancerous lesions undergo a postpartum regression, due to stimulatory effects of the immune microenvironment. 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Balan, Raluca Anca ; Socolov, Demetra ; Gheorghiță, Vlad Radu ; Buțureanu, Tudor Andrei ; Păvăleanu, Ioana ; Coșovanu, Elena Teona ; Căruntu, Irina-Draga</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-b1cea7507cc0dd31add5bcc1a72773e255b17968f817ac1a5353d81b027413fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Care and treatment</topic><topic>Cellular biology</topic><topic>Cervical cancer</topic><topic>Cervix</topic><topic>Complications and side effects</topic><topic>Diagnosis</topic><topic>Estrogens</topic><topic>Fertility</topic><topic>Hormones</topic><topic>Human papillomavirus</topic><topic>Immune system</topic><topic>Immunology</topic><topic>Infections</topic><topic>Medical screening</topic><topic>Microbiota</topic><topic>Pap smear</topic><topic>Pathogenesis</topic><topic>Physiology</topic><topic>Postpartum period</topic><topic>Pregnancy</topic><topic>Pregnancy, Complications of</topic><topic>Review</topic><topic>Risk factors</topic><topic>Vagina</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Balan, Teodora Ana</creatorcontrib><creatorcontrib>Balan, Raluca Anca</creatorcontrib><creatorcontrib>Socolov, Demetra</creatorcontrib><creatorcontrib>Gheorghiță, Vlad Radu</creatorcontrib><creatorcontrib>Buțureanu, Tudor Andrei</creatorcontrib><creatorcontrib>Păvăleanu, Ioana</creatorcontrib><creatorcontrib>Coșovanu, Elena Teona</creatorcontrib><creatorcontrib>Căruntu, Irina-Draga</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Balan, Teodora Ana</au><au>Balan, Raluca Anca</au><au>Socolov, Demetra</au><au>Gheorghiță, Vlad Radu</au><au>Buțureanu, Tudor Andrei</au><au>Păvăleanu, Ioana</au><au>Coșovanu, Elena Teona</au><au>Căruntu, Irina-Draga</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pregnancy-Related Precancerous Cervical Lesions: Pathogenesis, Diagnosis, Evolution, and Impact upon Gestation and Fertility</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2024-11-08</date><risdate>2024</risdate><volume>13</volume><issue>22</issue><spage>6718</spage><pages>6718-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>More common than cervical cancer, cervical intraepithelial neoplasia (CIN) represents a precursor lesion of cervical carcinoma, being associated with HPV infection. Due to the bidirectional relationship between HPV and estrogen and progesterone in pregnancy, most of the published data claim that precancerous lesions remain stable or even regress during pregnancy, although several studies have indicated the tendency of HSILs to persist. It is considered that pregnancy-related cervical precancerous lesions undergo a postpartum regression, due to stimulatory effects of the immune microenvironment. 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| subjects | Care and treatment Cellular biology Cervical cancer Cervix Complications and side effects Diagnosis Estrogens Fertility Hormones Human papillomavirus Immune system Immunology Infections Medical screening Microbiota Pap smear Pathogenesis Physiology Postpartum period Pregnancy Pregnancy, Complications of Review Risk factors Vagina Womens health |
| title | Pregnancy-Related Precancerous Cervical Lesions: Pathogenesis, Diagnosis, Evolution, and Impact upon Gestation and Fertility |
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