Mineralocorticoid Receptor and Sleep Quality in Chronic Kidney Disease
The classical function of the mineralocorticoid receptor (MR) is to maintain electrolytic homeostasis and control extracellular volume and blood pressure. The MR is expressed in the central nervous system (CNS) and is involved in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis as wel...
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| Veröffentlicht in: | International journal of molecular sciences 2024-11, Vol.25 (22), p.12320 |
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| creator | de la Puente-Aldea, Juan Lopez-Llanos, Oscar Horrillo, Daniel Marcos-Sanchez, Hortensia Sanz-Ballesteros, Sandra Franco, Raquel Jaisser, Frederic Senovilla, Laura Palacios-Ramirez, Roberto |
| description | The classical function of the mineralocorticoid receptor (MR) is to maintain electrolytic homeostasis and control extracellular volume and blood pressure. The MR is expressed in the central nervous system (CNS) and is involved in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis as well as sleep physiology, playing a role in the non-rapid eye movement (NREM) phase of sleep. Some patients with psychiatric disorders have very poor sleep quality, and a relationship between MR dysregulation and this disorder has been found in them. In addition, the MR is involved in the regulation of the renal peripheral clock. One of the most common comorbidities observed in patients with chronic kidney disease (CKD) is poor sleep quality. Patients with CKD experience sleep disturbances, including reduced sleep duration, sleep fragmentation, and insomnia. To date, no studies have specifically investigated the relationship between MR activation and CKD-associated sleep disturbances. However, in this review, we analyzed the environment that occurs in CKD and proposed two MR-related mechanisms that may be responsible for these sleep disturbances: the circadian clock disruption and the high levels of MR agonist observed in CKD. |
| doi_str_mv | 10.3390/ijms252212320 |
| format | Article |
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The MR is expressed in the central nervous system (CNS) and is involved in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis as well as sleep physiology, playing a role in the non-rapid eye movement (NREM) phase of sleep. Some patients with psychiatric disorders have very poor sleep quality, and a relationship between MR dysregulation and this disorder has been found in them. In addition, the MR is involved in the regulation of the renal peripheral clock. One of the most common comorbidities observed in patients with chronic kidney disease (CKD) is poor sleep quality. Patients with CKD experience sleep disturbances, including reduced sleep duration, sleep fragmentation, and insomnia. To date, no studies have specifically investigated the relationship between MR activation and CKD-associated sleep disturbances. However, in this review, we analyzed the environment that occurs in CKD and proposed two MR-related mechanisms that may be responsible for these sleep disturbances: the circadian clock disruption and the high levels of MR agonist observed in CKD.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>EISSN: 1661-6596</identifier><identifier>DOI: 10.3390/ijms252212320</identifier><identifier>PMID: 39596384</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animals ; Chronic kidney failure ; Circadian Clocks ; Fludrocortisone ; Homeostasis ; Hormones ; Humans ; Hypothalamo-Hypophyseal System - metabolism ; Hypothalamo-Hypophyseal System - physiopathology ; Insomnia ; Kidney diseases ; Life Sciences ; Ligands ; Physiological aspects ; Physiology ; Pituitary-Adrenal System - metabolism ; Proteins ; Receptors, Mineralocorticoid - metabolism ; Renal Insufficiency, Chronic - complications ; Renal Insufficiency, Chronic - metabolism ; Renal Insufficiency, Chronic - physiopathology ; Restless legs syndrome ; Review ; Sleep ; Sleep deprivation ; Sleep Quality ; Sleep Wake Disorders - metabolism ; Sleep Wake Disorders - physiopathology ; Steroids</subject><ispartof>International journal of molecular sciences, 2024-11, Vol.25 (22), p.12320</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c403t-9eeff7f50710e28c2ca1b1ac7f5532bd22422bb266728c002868a84c3f68508d3</cites><orcidid>0009-0007-0355-0250 ; 0009-0004-1413-0671 ; 0000-0001-6887-2436 ; 0000-0002-0867-1277 ; 0000-0001-6115-4677</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11594958/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11594958/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39596384$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.sorbonne-universite.fr/hal-04836321$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>de la Puente-Aldea, Juan</creatorcontrib><creatorcontrib>Lopez-Llanos, Oscar</creatorcontrib><creatorcontrib>Horrillo, Daniel</creatorcontrib><creatorcontrib>Marcos-Sanchez, Hortensia</creatorcontrib><creatorcontrib>Sanz-Ballesteros, Sandra</creatorcontrib><creatorcontrib>Franco, Raquel</creatorcontrib><creatorcontrib>Jaisser, Frederic</creatorcontrib><creatorcontrib>Senovilla, Laura</creatorcontrib><creatorcontrib>Palacios-Ramirez, Roberto</creatorcontrib><title>Mineralocorticoid Receptor and Sleep Quality in Chronic Kidney Disease</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>The classical function of the mineralocorticoid receptor (MR) is to maintain electrolytic homeostasis and control extracellular volume and blood pressure. The MR is expressed in the central nervous system (CNS) and is involved in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis as well as sleep physiology, playing a role in the non-rapid eye movement (NREM) phase of sleep. Some patients with psychiatric disorders have very poor sleep quality, and a relationship between MR dysregulation and this disorder has been found in them. In addition, the MR is involved in the regulation of the renal peripheral clock. One of the most common comorbidities observed in patients with chronic kidney disease (CKD) is poor sleep quality. Patients with CKD experience sleep disturbances, including reduced sleep duration, sleep fragmentation, and insomnia. To date, no studies have specifically investigated the relationship between MR activation and CKD-associated sleep disturbances. However, in this review, we analyzed the environment that occurs in CKD and proposed two MR-related mechanisms that may be responsible for these sleep disturbances: the circadian clock disruption and the high levels of MR agonist observed in CKD.</description><subject>Animals</subject><subject>Chronic kidney failure</subject><subject>Circadian Clocks</subject><subject>Fludrocortisone</subject><subject>Homeostasis</subject><subject>Hormones</subject><subject>Humans</subject><subject>Hypothalamo-Hypophyseal System - metabolism</subject><subject>Hypothalamo-Hypophyseal System - physiopathology</subject><subject>Insomnia</subject><subject>Kidney diseases</subject><subject>Life Sciences</subject><subject>Ligands</subject><subject>Physiological aspects</subject><subject>Physiology</subject><subject>Pituitary-Adrenal System - metabolism</subject><subject>Proteins</subject><subject>Receptors, Mineralocorticoid - metabolism</subject><subject>Renal Insufficiency, Chronic - complications</subject><subject>Renal Insufficiency, Chronic - 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metabolism</topic><topic>Hypothalamo-Hypophyseal System - physiopathology</topic><topic>Insomnia</topic><topic>Kidney diseases</topic><topic>Life Sciences</topic><topic>Ligands</topic><topic>Physiological aspects</topic><topic>Physiology</topic><topic>Pituitary-Adrenal System - metabolism</topic><topic>Proteins</topic><topic>Receptors, Mineralocorticoid - metabolism</topic><topic>Renal Insufficiency, Chronic - complications</topic><topic>Renal Insufficiency, Chronic - metabolism</topic><topic>Renal Insufficiency, Chronic - physiopathology</topic><topic>Restless legs syndrome</topic><topic>Review</topic><topic>Sleep</topic><topic>Sleep deprivation</topic><topic>Sleep Quality</topic><topic>Sleep Wake Disorders - metabolism</topic><topic>Sleep Wake Disorders - physiopathology</topic><topic>Steroids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de la Puente-Aldea, Juan</creatorcontrib><creatorcontrib>Lopez-Llanos, Oscar</creatorcontrib><creatorcontrib>Horrillo, Daniel</creatorcontrib><creatorcontrib>Marcos-Sanchez, Hortensia</creatorcontrib><creatorcontrib>Sanz-Ballesteros, Sandra</creatorcontrib><creatorcontrib>Franco, Raquel</creatorcontrib><creatorcontrib>Jaisser, Frederic</creatorcontrib><creatorcontrib>Senovilla, Laura</creatorcontrib><creatorcontrib>Palacios-Ramirez, Roberto</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - 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The MR is expressed in the central nervous system (CNS) and is involved in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis as well as sleep physiology, playing a role in the non-rapid eye movement (NREM) phase of sleep. Some patients with psychiatric disorders have very poor sleep quality, and a relationship between MR dysregulation and this disorder has been found in them. In addition, the MR is involved in the regulation of the renal peripheral clock. One of the most common comorbidities observed in patients with chronic kidney disease (CKD) is poor sleep quality. Patients with CKD experience sleep disturbances, including reduced sleep duration, sleep fragmentation, and insomnia. To date, no studies have specifically investigated the relationship between MR activation and CKD-associated sleep disturbances. 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| ispartof | International journal of molecular sciences, 2024-11, Vol.25 (22), p.12320 |
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| subjects | Animals Chronic kidney failure Circadian Clocks Fludrocortisone Homeostasis Hormones Humans Hypothalamo-Hypophyseal System - metabolism Hypothalamo-Hypophyseal System - physiopathology Insomnia Kidney diseases Life Sciences Ligands Physiological aspects Physiology Pituitary-Adrenal System - metabolism Proteins Receptors, Mineralocorticoid - metabolism Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - metabolism Renal Insufficiency, Chronic - physiopathology Restless legs syndrome Review Sleep Sleep deprivation Sleep Quality Sleep Wake Disorders - metabolism Sleep Wake Disorders - physiopathology Steroids |
| title | Mineralocorticoid Receptor and Sleep Quality in Chronic Kidney Disease |
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