Thrombosis in Paroxysmal Nocturnal Hemoglobinuria (PNH): From Pathogenesis to Treatment

Paroxysmal Nocturnal Hemoglobinuria (PNH) constitutes a rare bone marrow failure syndrome characterized by hemolytic anemia, thrombotic events (TEs), and bone marrow aplasia of variable degrees. Thrombosis is one of the major clinical manifestations of the disease, affecting up to 40% of individuals...

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Veröffentlicht in:	International journal of molecular sciences 2024-11, Vol.25 (22), p.12104
Hauptverfasser:	Kokoris, Styliani, Polyviou, Antri, Evangelidis, Paschalis, Grouzi, Elisavet, Valsami, Serena, Tragiannidis, Konstantinos, Gialeraki, Argyri, Tsakiris, Dimitrios A, Gavriilaki, Eleni
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia Antibodies, Monoclonal, Humanized - therapeutic use Anticoagulants (Medicine) Anticoagulants - therapeutic use Blood clot Bone marrow Cloning Complement Activation - drug effects Complement Inactivating Agents - therapeutic use COVID-19 Endothelium FDA approval Flow cytometry Hematology Hemoglobinuria, Paroxysmal - complications Hemoglobinuria, Paroxysmal - drug therapy Hemoglobinuria, Paroxysmal - therapy Humans Mortality Neutrophils Nitric oxide Pharmaceuticals Review Risk factors Thromboembolism Thrombosis Thrombosis - drug therapy Thrombosis - etiology Veins & arteries
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