Identifying an Inversin as a Novel Prognostic Marker in Patients with Clear-Cell Renal Cell Carcinoma
Precision medicine is a developing trend in oncology, and it includes the prognosis and treatment of advanced-stage ccRCC. New predictive factors and therapeutic targets for this disease are steadily needed. The aim of this study was to explore the tumor expression of inversin as a potential prognos...
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| Veröffentlicht in: | International journal of molecular sciences 2024-11, Vol.25 (22), p.12120 |
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| creator | Urlić, Ivanka Šoljić, Violeta Vukoja, Martina Marijanović, Inga Kraljević, Marija Urlić, Marjan Marić, Sara Vukojević, Katarina Filipović, Natalija |
| description | Precision medicine is a developing trend in oncology, and it includes the prognosis and treatment of advanced-stage ccRCC. New predictive factors and therapeutic targets for this disease are steadily needed. The aim of this study was to explore the tumor expression of inversin as a potential prognostic factor and/or therapeutic target in ccRCC. We compared the expression of inversin between primary ccRCC and normal renal tissues by using immunohistochemistry and rtPCR in our cohort, and we also analyzed publicly available data from the TCGA-KIRC cohort. We found that the expression of inversin was significantly lower in primary tumor tissue, in comparison to solid normal tissue. Data from the KIRC study confirmed that a lower
expression level in ccRCC was significantly related with the overall and disease-specific survival, as well as with a shorter progression-free interval (
< 0.05). Four out of ten inversin interactome partners were significantly related with the overall and disease-specific survival in ccRCC. A lower expression of
was a negative survival predictor, while a higher expression of
,
, or
was related with a lower survival. The expression of
and its interactome partners in ccRCC was correlated with the differentiation of the tumor and metastasis. The expression of
and its partners was also correlated with tumor leukocyte infiltration and the expression of immune checkpoint genes. The results of this study point to inversin and a distinguished group of its interactome partners as potential prognostic factors in ccRCC, with their predominant involvement in the modulation of the inflammatory infiltration of the tumor microenvironment and a strong relationship with the metastatic potential of the tumor. |
| doi_str_mv | 10.3390/ijms252212120 |
| format | Article |
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expression level in ccRCC was significantly related with the overall and disease-specific survival, as well as with a shorter progression-free interval (
< 0.05). Four out of ten inversin interactome partners were significantly related with the overall and disease-specific survival in ccRCC. A lower expression of
was a negative survival predictor, while a higher expression of
,
, or
was related with a lower survival. The expression of
and its interactome partners in ccRCC was correlated with the differentiation of the tumor and metastasis. The expression of
and its partners was also correlated with tumor leukocyte infiltration and the expression of immune checkpoint genes. The results of this study point to inversin and a distinguished group of its interactome partners as potential prognostic factors in ccRCC, with their predominant involvement in the modulation of the inflammatory infiltration of the tumor microenvironment and a strong relationship with the metastatic potential of the tumor.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms252212120</identifier><identifier>PMID: 39596188</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Aged ; Biomarkers, Tumor - genetics ; Biomarkers, Tumor - metabolism ; Cancer ; Carcinoma, Renal Cell - genetics ; Carcinoma, Renal Cell - metabolism ; Carcinoma, Renal Cell - mortality ; Carcinoma, Renal Cell - pathology ; Comparative analysis ; Development and progression ; Disease ; Female ; Gene Expression Regulation, Neoplastic ; Health aspects ; Histology ; Humans ; Immunohistochemistry ; Ipilimumab ; Kidney cancer ; Kidney Neoplasms - genetics ; Kidney Neoplasms - metabolism ; Kidney Neoplasms - mortality ; Kidney Neoplasms - pathology ; Liu, Timothy ; Lung cancer ; Male ; Medical prognosis ; Metastasis ; Middle Aged ; Mutation ; Pathogenesis ; Patients ; Prognosis ; Proteins ; Surveillance ; Tumors</subject><ispartof>International journal of molecular sciences, 2024-11, Vol.25 (22), p.12120</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c330t-665dde13cb399b556fb94ebcd06246a2013a1c829f963ff0b4d940012d3b192c3</cites><orcidid>0000-0002-8943-4109 ; 0000-0003-2182-2890 ; 0000-0003-0741-9333</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11594840/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11594840/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39596188$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Urlić, Ivanka</creatorcontrib><creatorcontrib>Šoljić, Violeta</creatorcontrib><creatorcontrib>Vukoja, Martina</creatorcontrib><creatorcontrib>Marijanović, Inga</creatorcontrib><creatorcontrib>Kraljević, Marija</creatorcontrib><creatorcontrib>Urlić, Marjan</creatorcontrib><creatorcontrib>Marić, Sara</creatorcontrib><creatorcontrib>Vukojević, Katarina</creatorcontrib><creatorcontrib>Filipović, Natalija</creatorcontrib><title>Identifying an Inversin as a Novel Prognostic Marker in Patients with Clear-Cell Renal Cell Carcinoma</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Precision medicine is a developing trend in oncology, and it includes the prognosis and treatment of advanced-stage ccRCC. New predictive factors and therapeutic targets for this disease are steadily needed. The aim of this study was to explore the tumor expression of inversin as a potential prognostic factor and/or therapeutic target in ccRCC. We compared the expression of inversin between primary ccRCC and normal renal tissues by using immunohistochemistry and rtPCR in our cohort, and we also analyzed publicly available data from the TCGA-KIRC cohort. We found that the expression of inversin was significantly lower in primary tumor tissue, in comparison to solid normal tissue. Data from the KIRC study confirmed that a lower
expression level in ccRCC was significantly related with the overall and disease-specific survival, as well as with a shorter progression-free interval (
< 0.05). Four out of ten inversin interactome partners were significantly related with the overall and disease-specific survival in ccRCC. A lower expression of
was a negative survival predictor, while a higher expression of
,
, or
was related with a lower survival. The expression of
and its interactome partners in ccRCC was correlated with the differentiation of the tumor and metastasis. The expression of
and its partners was also correlated with tumor leukocyte infiltration and the expression of immune checkpoint genes. The results of this study point to inversin and a distinguished group of its interactome partners as potential prognostic factors in ccRCC, with their predominant involvement in the modulation of the inflammatory infiltration of the tumor microenvironment and a strong relationship with the metastatic potential of the tumor.</description><subject>Aged</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Cancer</subject><subject>Carcinoma, Renal Cell - genetics</subject><subject>Carcinoma, Renal Cell - metabolism</subject><subject>Carcinoma, Renal Cell - mortality</subject><subject>Carcinoma, Renal Cell - pathology</subject><subject>Comparative analysis</subject><subject>Development and progression</subject><subject>Disease</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Health aspects</subject><subject>Histology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Ipilimumab</subject><subject>Kidney cancer</subject><subject>Kidney Neoplasms - genetics</subject><subject>Kidney Neoplasms - metabolism</subject><subject>Kidney Neoplasms - mortality</subject><subject>Kidney Neoplasms - pathology</subject><subject>Liu, Timothy</subject><subject>Lung cancer</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Pathogenesis</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Surveillance</subject><subject>Tumors</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptktFvFCEQxomxsbX66Ksh8cWXbYEBbnkyzcbqJVUbo8-EZeHKuQsV9q7pfy_1au0ZMw9MmN98w5APoVeUnAAochrWU2GCMVqDPEFHlDPWECIXTx_lh-h5KWtCGDChnqFDUEJJ2rZHyC0HF-fgb0NcYRPxMm5dLiFiU7DBn9PWjfgyp1VMZQ4WfzL5h8u41i_NHGpnwTdhvsLd6ExuOjeO-KuLZsS_085kG2KazAt04M1Y3Mv78xh9P3__rfvYXHz5sOzOLhoLQOZGSjEMjoLtQaleCOl7xV1vByIZl4YRCobalimvJHhPej4oTghlA_RUMQvH6N1O93rTT26w9YHZjPo6h8nkW51M0PuVGK70Km01pULxlpOq8PZeIaefG1dmPYVi6zImurQpGigAFwvgrKJv_kHXaZPr8juKKCpY-5damdHpEH2qg-2dqD5raQuwYAtZqZP_UDUGNwWbovOh3u81NLsGm1Mp2fmHJSnRd8bQe8ao_OvHP_NA_3EC_AI7NrI2</recordid><startdate>20241112</startdate><enddate>20241112</enddate><creator>Urlić, Ivanka</creator><creator>Šoljić, Violeta</creator><creator>Vukoja, Martina</creator><creator>Marijanović, Inga</creator><creator>Kraljević, Marija</creator><creator>Urlić, Marjan</creator><creator>Marić, Sara</creator><creator>Vukojević, Katarina</creator><creator>Filipović, Natalija</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8943-4109</orcidid><orcidid>https://orcid.org/0000-0003-2182-2890</orcidid><orcidid>https://orcid.org/0000-0003-0741-9333</orcidid></search><sort><creationdate>20241112</creationdate><title>Identifying an Inversin as a Novel Prognostic Marker in Patients with Clear-Cell Renal Cell Carcinoma</title><author>Urlić, Ivanka ; Šoljić, Violeta ; Vukoja, Martina ; Marijanović, Inga ; Kraljević, Marija ; Urlić, Marjan ; Marić, Sara ; Vukojević, Katarina ; Filipović, Natalija</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c330t-665dde13cb399b556fb94ebcd06246a2013a1c829f963ff0b4d940012d3b192c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Cancer</topic><topic>Carcinoma, Renal Cell - genetics</topic><topic>Carcinoma, Renal Cell - metabolism</topic><topic>Carcinoma, Renal Cell - mortality</topic><topic>Carcinoma, Renal Cell - pathology</topic><topic>Comparative analysis</topic><topic>Development and progression</topic><topic>Disease</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Health aspects</topic><topic>Histology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Ipilimumab</topic><topic>Kidney cancer</topic><topic>Kidney Neoplasms - genetics</topic><topic>Kidney Neoplasms - metabolism</topic><topic>Kidney Neoplasms - mortality</topic><topic>Kidney Neoplasms - pathology</topic><topic>Liu, Timothy</topic><topic>Lung cancer</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Pathogenesis</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Proteins</topic><topic>Surveillance</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Urlić, Ivanka</creatorcontrib><creatorcontrib>Šoljić, Violeta</creatorcontrib><creatorcontrib>Vukoja, Martina</creatorcontrib><creatorcontrib>Marijanović, Inga</creatorcontrib><creatorcontrib>Kraljević, Marija</creatorcontrib><creatorcontrib>Urlić, Marjan</creatorcontrib><creatorcontrib>Marić, Sara</creatorcontrib><creatorcontrib>Vukojević, Katarina</creatorcontrib><creatorcontrib>Filipović, Natalija</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Urlić, Ivanka</au><au>Šoljić, Violeta</au><au>Vukoja, Martina</au><au>Marijanović, Inga</au><au>Kraljević, Marija</au><au>Urlić, Marjan</au><au>Marić, Sara</au><au>Vukojević, Katarina</au><au>Filipović, Natalija</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identifying an Inversin as a Novel Prognostic Marker in Patients with Clear-Cell Renal Cell Carcinoma</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2024-11-12</date><risdate>2024</risdate><volume>25</volume><issue>22</issue><spage>12120</spage><pages>12120-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Precision medicine is a developing trend in oncology, and it includes the prognosis and treatment of advanced-stage ccRCC. New predictive factors and therapeutic targets for this disease are steadily needed. The aim of this study was to explore the tumor expression of inversin as a potential prognostic factor and/or therapeutic target in ccRCC. We compared the expression of inversin between primary ccRCC and normal renal tissues by using immunohistochemistry and rtPCR in our cohort, and we also analyzed publicly available data from the TCGA-KIRC cohort. We found that the expression of inversin was significantly lower in primary tumor tissue, in comparison to solid normal tissue. Data from the KIRC study confirmed that a lower
expression level in ccRCC was significantly related with the overall and disease-specific survival, as well as with a shorter progression-free interval (
< 0.05). Four out of ten inversin interactome partners were significantly related with the overall and disease-specific survival in ccRCC. A lower expression of
was a negative survival predictor, while a higher expression of
,
, or
was related with a lower survival. The expression of
and its interactome partners in ccRCC was correlated with the differentiation of the tumor and metastasis. The expression of
and its partners was also correlated with tumor leukocyte infiltration and the expression of immune checkpoint genes. The results of this study point to inversin and a distinguished group of its interactome partners as potential prognostic factors in ccRCC, with their predominant involvement in the modulation of the inflammatory infiltration of the tumor microenvironment and a strong relationship with the metastatic potential of the tumor.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39596188</pmid><doi>10.3390/ijms252212120</doi><orcidid>https://orcid.org/0000-0002-8943-4109</orcidid><orcidid>https://orcid.org/0000-0003-2182-2890</orcidid><orcidid>https://orcid.org/0000-0003-0741-9333</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cancer Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - mortality Carcinoma, Renal Cell - pathology Comparative analysis Development and progression Disease Female Gene Expression Regulation, Neoplastic Health aspects Histology Humans Immunohistochemistry Ipilimumab Kidney cancer Kidney Neoplasms - genetics Kidney Neoplasms - metabolism Kidney Neoplasms - mortality Kidney Neoplasms - pathology Liu, Timothy Lung cancer Male Medical prognosis Metastasis Middle Aged Mutation Pathogenesis Patients Prognosis Proteins Surveillance Tumors |
| title | Identifying an Inversin as a Novel Prognostic Marker in Patients with Clear-Cell Renal Cell Carcinoma |
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