Alcohol Alters Skeletal Muscle Bioenergetic Function: A Scoping Review
Bioenergetic pathways uniquely support sarcomere function which, in turn, helps to maintain functional skeletal muscle (SKM) mass. Emerging evidence supports alcohol (EtOH)-induced bioenergetic impairments in SKM and muscle precursor cells. We performed a scoping review to synthesize existing eviden...
Gespeichert in:
| Veröffentlicht in: | International journal of molecular sciences 2024-11, Vol.25 (22), p.12280 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 22 |
| container_start_page | 12280 |
| container_title | International journal of molecular sciences |
| container_volume | 25 |
| creator | DiLeo, Matthew R Hall, Rylea E Vellers, Heather L Daniels, Chelsea L Levitt, Danielle E |
| description | Bioenergetic pathways uniquely support sarcomere function which, in turn, helps to maintain functional skeletal muscle (SKM) mass. Emerging evidence supports alcohol (EtOH)-induced bioenergetic impairments in SKM and muscle precursor cells. We performed a scoping review to synthesize existing evidence regarding the effects of EtOH on SKM bioenergetics. Eligible articles from six databases were identified, and titles, abstracts, and full texts for potentially relevant articles were screened against inclusion criteria. Through the search, we identified 555 unique articles, and 21 met inclusion criteria. Three studies investigated EtOH effects on the adenosine triphosphate (ATP)-phosphocreatine (PCr) system, twelve investigated EtOH effects on glycolytic metabolism, and seventeen investigated EtOH effects on mitochondrial metabolism. Despite increased ATP-PCr system reliance, EtOH led to an overall decrease in bioenergetic function through decreased expression and activity of glycolytic and mitochondrial pathway components. However, effects varied depending on the EtOH dose and duration, model system, and sample type. The results detail the EtOH-induced shifts in energy metabolism, which may adversely affect sarcomere function and contribute to myopathy. These findings should be used to develop targeted interventions that improve SKM bioenergetic function, and thus sarcomere function, in people with Alcohol Use Disorder (AUD). Key areas in need of further investigation are also identified. |
| doi_str_mv | 10.3390/ijms252212280 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11594450</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A818337705</galeid><sourcerecordid>A818337705</sourcerecordid><originalsourceid>FETCH-LOGICAL-c330t-b876f9da4ee87eb858e3159153fbdaef9110936d426a38da5b021181491951103</originalsourceid><addsrcrecordid>eNptkU1v1DAQhi1ERUvhyBVF4sIlxZ-JzQWFigWkVkgUzpbjTLZeHHuxkyL-PV5a2m6F5uCR55l3NPMi9ILgE8YUfuM2U6aCUkKpxI_QEeGU1hg37eN7-SF6mvMGY8qoUE_QIVNCNYyLI7TqvI2X0VednyHl6uIHeJiNr86XbD1U712EAGkNs7PVagl2djG8rbrqwsatC-vqK1w5-PUMHYzGZ3h-8x6j76sP304_1WdfPn4-7c5qyxie6162zagGwwFkC70UEhgRigg29oOBURGCFWsGThvD5GBEjykhknBFlCg1dozeXetul36CwUKYk_F6m9xk0m8djdP7leAu9TpeaVLGcC52Cq9vFFL8uUCe9eSyBe9NgLhkzQgrh2kFbgv66gG6iUsKZb-_FFaES35HrY0H7cIYy2C7E9WdJJKxtsWiUCf_oUoMMDkbA4yu_O811NcNNsWcE4y3SxKsd87rPecL__L-ZW7pf1azPyqrprM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3133091484</pqid></control><display><type>article</type><title>Alcohol Alters Skeletal Muscle Bioenergetic Function: A Scoping Review</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>PubMed Central</source><creator>DiLeo, Matthew R ; Hall, Rylea E ; Vellers, Heather L ; Daniels, Chelsea L ; Levitt, Danielle E</creator><creatorcontrib>DiLeo, Matthew R ; Hall, Rylea E ; Vellers, Heather L ; Daniels, Chelsea L ; Levitt, Danielle E</creatorcontrib><description>Bioenergetic pathways uniquely support sarcomere function which, in turn, helps to maintain functional skeletal muscle (SKM) mass. Emerging evidence supports alcohol (EtOH)-induced bioenergetic impairments in SKM and muscle precursor cells. We performed a scoping review to synthesize existing evidence regarding the effects of EtOH on SKM bioenergetics. Eligible articles from six databases were identified, and titles, abstracts, and full texts for potentially relevant articles were screened against inclusion criteria. Through the search, we identified 555 unique articles, and 21 met inclusion criteria. Three studies investigated EtOH effects on the adenosine triphosphate (ATP)-phosphocreatine (PCr) system, twelve investigated EtOH effects on glycolytic metabolism, and seventeen investigated EtOH effects on mitochondrial metabolism. Despite increased ATP-PCr system reliance, EtOH led to an overall decrease in bioenergetic function through decreased expression and activity of glycolytic and mitochondrial pathway components. However, effects varied depending on the EtOH dose and duration, model system, and sample type. The results detail the EtOH-induced shifts in energy metabolism, which may adversely affect sarcomere function and contribute to myopathy. These findings should be used to develop targeted interventions that improve SKM bioenergetic function, and thus sarcomere function, in people with Alcohol Use Disorder (AUD). Key areas in need of further investigation are also identified.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms252212280</identifier><identifier>PMID: 39596345</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adenosine Triphosphate - metabolism ; Alcohol ; Analysis ; Animals ; Bioenergetics ; Drinking of alcoholic beverages ; Energy metabolism ; Energy Metabolism - drug effects ; Enzymes ; Ethanol - adverse effects ; Ethanol - pharmacology ; Glycolysis - drug effects ; Health aspects ; Humans ; Metabolism ; Metabolites ; Mitochondria - drug effects ; Mitochondria - metabolism ; Muscle, Skeletal - drug effects ; Muscle, Skeletal - metabolism ; Muscles ; Musculoskeletal system ; Phosphocreatine - metabolism ; Physiology ; Proteins ; Review ; Rodents</subject><ispartof>International journal of molecular sciences, 2024-11, Vol.25 (22), p.12280</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c330t-b876f9da4ee87eb858e3159153fbdaef9110936d426a38da5b021181491951103</cites><orcidid>0000-0003-1865-1971 ; 0009-0009-8977-2472</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11594450/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11594450/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39596345$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DiLeo, Matthew R</creatorcontrib><creatorcontrib>Hall, Rylea E</creatorcontrib><creatorcontrib>Vellers, Heather L</creatorcontrib><creatorcontrib>Daniels, Chelsea L</creatorcontrib><creatorcontrib>Levitt, Danielle E</creatorcontrib><title>Alcohol Alters Skeletal Muscle Bioenergetic Function: A Scoping Review</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Bioenergetic pathways uniquely support sarcomere function which, in turn, helps to maintain functional skeletal muscle (SKM) mass. Emerging evidence supports alcohol (EtOH)-induced bioenergetic impairments in SKM and muscle precursor cells. We performed a scoping review to synthesize existing evidence regarding the effects of EtOH on SKM bioenergetics. Eligible articles from six databases were identified, and titles, abstracts, and full texts for potentially relevant articles were screened against inclusion criteria. Through the search, we identified 555 unique articles, and 21 met inclusion criteria. Three studies investigated EtOH effects on the adenosine triphosphate (ATP)-phosphocreatine (PCr) system, twelve investigated EtOH effects on glycolytic metabolism, and seventeen investigated EtOH effects on mitochondrial metabolism. Despite increased ATP-PCr system reliance, EtOH led to an overall decrease in bioenergetic function through decreased expression and activity of glycolytic and mitochondrial pathway components. However, effects varied depending on the EtOH dose and duration, model system, and sample type. The results detail the EtOH-induced shifts in energy metabolism, which may adversely affect sarcomere function and contribute to myopathy. These findings should be used to develop targeted interventions that improve SKM bioenergetic function, and thus sarcomere function, in people with Alcohol Use Disorder (AUD). Key areas in need of further investigation are also identified.</description><subject>Adenosine Triphosphate - metabolism</subject><subject>Alcohol</subject><subject>Analysis</subject><subject>Animals</subject><subject>Bioenergetics</subject><subject>Drinking of alcoholic beverages</subject><subject>Energy metabolism</subject><subject>Energy Metabolism - drug effects</subject><subject>Enzymes</subject><subject>Ethanol - adverse effects</subject><subject>Ethanol - pharmacology</subject><subject>Glycolysis - drug effects</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Mitochondria - drug effects</subject><subject>Mitochondria - metabolism</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscles</subject><subject>Musculoskeletal system</subject><subject>Phosphocreatine - metabolism</subject><subject>Physiology</subject><subject>Proteins</subject><subject>Review</subject><subject>Rodents</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkU1v1DAQhi1ERUvhyBVF4sIlxZ-JzQWFigWkVkgUzpbjTLZeHHuxkyL-PV5a2m6F5uCR55l3NPMi9ILgE8YUfuM2U6aCUkKpxI_QEeGU1hg37eN7-SF6mvMGY8qoUE_QIVNCNYyLI7TqvI2X0VednyHl6uIHeJiNr86XbD1U712EAGkNs7PVagl2djG8rbrqwsatC-vqK1w5-PUMHYzGZ3h-8x6j76sP304_1WdfPn4-7c5qyxie6162zagGwwFkC70UEhgRigg29oOBURGCFWsGThvD5GBEjykhknBFlCg1dozeXetul36CwUKYk_F6m9xk0m8djdP7leAu9TpeaVLGcC52Cq9vFFL8uUCe9eSyBe9NgLhkzQgrh2kFbgv66gG6iUsKZb-_FFaES35HrY0H7cIYy2C7E9WdJJKxtsWiUCf_oUoMMDkbA4yu_O811NcNNsWcE4y3SxKsd87rPecL__L-ZW7pf1azPyqrprM</recordid><startdate>20241115</startdate><enddate>20241115</enddate><creator>DiLeo, Matthew R</creator><creator>Hall, Rylea E</creator><creator>Vellers, Heather L</creator><creator>Daniels, Chelsea L</creator><creator>Levitt, Danielle E</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1865-1971</orcidid><orcidid>https://orcid.org/0009-0009-8977-2472</orcidid></search><sort><creationdate>20241115</creationdate><title>Alcohol Alters Skeletal Muscle Bioenergetic Function: A Scoping Review</title><author>DiLeo, Matthew R ; Hall, Rylea E ; Vellers, Heather L ; Daniels, Chelsea L ; Levitt, Danielle E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c330t-b876f9da4ee87eb858e3159153fbdaef9110936d426a38da5b021181491951103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adenosine Triphosphate - metabolism</topic><topic>Alcohol</topic><topic>Analysis</topic><topic>Animals</topic><topic>Bioenergetics</topic><topic>Drinking of alcoholic beverages</topic><topic>Energy metabolism</topic><topic>Energy Metabolism - drug effects</topic><topic>Enzymes</topic><topic>Ethanol - adverse effects</topic><topic>Ethanol - pharmacology</topic><topic>Glycolysis - drug effects</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Mitochondria - drug effects</topic><topic>Mitochondria - metabolism</topic><topic>Muscle, Skeletal - drug effects</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscles</topic><topic>Musculoskeletal system</topic><topic>Phosphocreatine - metabolism</topic><topic>Physiology</topic><topic>Proteins</topic><topic>Review</topic><topic>Rodents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DiLeo, Matthew R</creatorcontrib><creatorcontrib>Hall, Rylea E</creatorcontrib><creatorcontrib>Vellers, Heather L</creatorcontrib><creatorcontrib>Daniels, Chelsea L</creatorcontrib><creatorcontrib>Levitt, Danielle E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DiLeo, Matthew R</au><au>Hall, Rylea E</au><au>Vellers, Heather L</au><au>Daniels, Chelsea L</au><au>Levitt, Danielle E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alcohol Alters Skeletal Muscle Bioenergetic Function: A Scoping Review</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2024-11-15</date><risdate>2024</risdate><volume>25</volume><issue>22</issue><spage>12280</spage><pages>12280-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Bioenergetic pathways uniquely support sarcomere function which, in turn, helps to maintain functional skeletal muscle (SKM) mass. Emerging evidence supports alcohol (EtOH)-induced bioenergetic impairments in SKM and muscle precursor cells. We performed a scoping review to synthesize existing evidence regarding the effects of EtOH on SKM bioenergetics. Eligible articles from six databases were identified, and titles, abstracts, and full texts for potentially relevant articles were screened against inclusion criteria. Through the search, we identified 555 unique articles, and 21 met inclusion criteria. Three studies investigated EtOH effects on the adenosine triphosphate (ATP)-phosphocreatine (PCr) system, twelve investigated EtOH effects on glycolytic metabolism, and seventeen investigated EtOH effects on mitochondrial metabolism. Despite increased ATP-PCr system reliance, EtOH led to an overall decrease in bioenergetic function through decreased expression and activity of glycolytic and mitochondrial pathway components. However, effects varied depending on the EtOH dose and duration, model system, and sample type. The results detail the EtOH-induced shifts in energy metabolism, which may adversely affect sarcomere function and contribute to myopathy. These findings should be used to develop targeted interventions that improve SKM bioenergetic function, and thus sarcomere function, in people with Alcohol Use Disorder (AUD). Key areas in need of further investigation are also identified.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39596345</pmid><doi>10.3390/ijms252212280</doi><orcidid>https://orcid.org/0000-0003-1865-1971</orcidid><orcidid>https://orcid.org/0009-0009-8977-2472</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1422-0067 |
| ispartof | International journal of molecular sciences, 2024-11, Vol.25 (22), p.12280 |
| issn | 1422-0067 1661-6596 1422-0067 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11594450 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Adenosine Triphosphate - metabolism Alcohol Analysis Animals Bioenergetics Drinking of alcoholic beverages Energy metabolism Energy Metabolism - drug effects Enzymes Ethanol - adverse effects Ethanol - pharmacology Glycolysis - drug effects Health aspects Humans Metabolism Metabolites Mitochondria - drug effects Mitochondria - metabolism Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscles Musculoskeletal system Phosphocreatine - metabolism Physiology Proteins Review Rodents |
| title | Alcohol Alters Skeletal Muscle Bioenergetic Function: A Scoping Review |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T16%3A14%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Alcohol%20Alters%20Skeletal%20Muscle%20Bioenergetic%20Function:%20A%20Scoping%20Review&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=DiLeo,%20Matthew%20R&rft.date=2024-11-15&rft.volume=25&rft.issue=22&rft.spage=12280&rft.pages=12280-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms252212280&rft_dat=%3Cgale_pubme%3EA818337705%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3133091484&rft_id=info:pmid/39596345&rft_galeid=A818337705&rfr_iscdi=true |