Hypoxia inhibits the recombinant alpha 1C subunit of the human cardiac L-type Ca2+ channel

1. Whole-cell patch clamp recordings were used to investigate the effects of hypoxia on recombinant human L-type Ca2+ channel alpha 1C subunits stably expressed in human embryonic kidney (HEK 293) cells. 2. Ca2+ channel currents were reversibly inhibited by hypoxia (PO2 < 90 mmHg). The degree of...

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Veröffentlicht in:	The Journal of physiology 1997-05, Vol.500 (Pt 3), p.551-556
Hauptverfasser:	Fearon, I M, Palmer, A C, Balmforth, A J, Ball, S G, Mikala, G, Schwartz, A, Peers, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Barium - metabolism Calcium Channels - metabolism Cells, Cultured Electrophysiology Humans Hypoxia - physiopathology Kidney - cytology Kidney - metabolism Kinetics Membrane Potentials - physiology Myocardium - metabolism Open Reading Frames Patch-Clamp Techniques Recombinant Proteins - metabolism Xenopus laevis
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