Single-cell multi-omic and spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progression

Kidneys are intricate three-dimensional structures in the body, yet the spatial and molecular principles of kidney health and disease remain inadequately understood. We generated high-quality datasets for 81 samples, including single-cell, single-nuclear, spot-level (Visium) and single-cell resoluti...

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Veröffentlicht in:	Nature genetics 2024-08, Vol.56 (8), p.1712-1724
Hauptverfasser:	Abedini, Amin, Levinsohn, Jonathan, Klötzer, Konstantin A., Dumoulin, Bernhard, Ma, Ziyuan, Frederick, Julia, Dhillon, Poonam, Balzer, Michael S., Shrestha, Rojesh, Liu, Hongbo, Vitale, Steven, Bergeson, Andi M., Devalaraja-Narashimha, Kishor, Grandi, Paola, Bhattacharyya, Tanmoy, Hu, Erding, Pullen, Steven S., Boustany-Kari, Carine M., Guarnieri, Paolo, Karihaloo, Anil, Traum, Daniel, Yan, Hanying, Coleman, Kyle, Palmer, Matthew, Sarov-Blat, Lea, Morton, Lori, Hunter, Christopher A., Kaestner, Klaus H., Li, Mingyao, Susztak, Katalin
Format:	Artikel
Sprache:	eng
Schlagworte:	45 631/61/191/2018 631/80 692/308/575 692/699/1585/104 Agriculture Animal Genetics and Genomics Biomedical and Life Sciences Biomedicine Cancer Research Cells Cellular Microenvironment - genetics Chromatin Datasets Diabetes Diabetes mellitus Disease Progression Fibrosis Gene expression Gene Expression Profiling Gene Function Histopathology Human Genetics Humans Hypertension Kidney - pathology Kidney diseases Kidney Diseases - genetics Kidney Diseases - pathology Kidneys Localization Microenvironments Multiomics Single-Cell Analysis Spatial data Transcriptome Transcriptomics
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