Autologous HER2-specific CAR T-cells after lymphodepletion for advanced sarcoma – A Phase I trial

In this prospective, interventional phase I study ( NCT00902044 ) for patients with advanced sarcoma, we infused autologous HER2-specific chimeric antigen receptor T-cells (HER2-CART) after lymphodepletion with cyclophosphamide (Cy) +/− fludarabine (Flu): 1×10 8 T-cells/m 2 after Flu (cohort A) or F...

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Veröffentlicht in:	Nature cancer 2024-04, Vol.5 (6), p.880-894
Hauptverfasser:	Hegde, Meenakshi, Navai, Shoba, DeRenzo, Christopher, Joseph, Sujith K., Sanber, Khaled, Wu, Mengfen, Gad, Ahmed Z., Janeway, Katherine A., Campbell, Matthew, Mullikin, Dolores, Nawas, Zeid, Robertson, Catherine, Mathew, Pretty R., Zhang, Huimin, Mehta, Birju, Bhat, Raksha R., Major, Angela, Shree, Ankita, Gerken, Claudia, Kalra, Mamta, Chakraborty, Rikhia, Thakar, Sachin G., Dakhova, Olga, Salsman, Vita S., Grilley, Bambi, Lapteva, Natalia, Gee, Adrian, Dotti, Gianpietro, Bao, Riyue, Salem, Ahmed Hamed, Wang, Tao, Brenner, Malcolm K., Heslop, Helen E., Wels, Winfried S., Hicks, M. John, Gottschalk, Stephen, Ahmed, Nabil
Format:	Artikel
Sprache:	eng
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