High affinity binding of anti-oestrogen to the chick liver nuclear oestrogen receptor

Tamoxifen is a potent inhibitor of specific oestrogen-induced yolk protein synthesis by chicken liver. The oestradiol receptor in salt extracts of liver nuclei from oestrogen-treated chicks has a K(d) for oestradiol of 0.7+/-0.2nm. Tamoxifen and its metabolite, monohydroxytamoxifen, compete for bind...

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Veröffentlicht in:	Biochemical journal 1982-08, Vol.206 (2), p.387-394
Hauptverfasser:	Lazier, C B, Jordan, V C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Nucleus - drug effects Cell Nucleus - metabolism Cell Surfaces and Receptors Chickens Estradiol - metabolism In Vitro Techniques Kinetics Liver - drug effects Liver - metabolism Male Receptors, Estrogen - drug effects Tamoxifen - analogs & derivatives Tamoxifen - pharmacology
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