Residues of TRPM8 at the Lipid-Water-Interface have Coevolved with Cholesterol Interaction and are Relevant for Diverse Health Disorders

TRPM8 is a non-selective cation channel that is expressed in several tissues and cells and also has a unique property to be activated by low-temperature. In this work, we have analyzed the conservation of amino acids that are present in the lipid-water-interface (LWI) region of TRPM8, the region whi...

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Veröffentlicht in:	The Journal of membrane biology 2024-12, Vol.257 (5-6), p.345-364
Hauptverfasser:	Shikha, Deep, Dalai, Ritesh, Kumar, Shamit, Goswami, Chandan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Animals Biochemistry Biomedical and Life Sciences Cancer Cholesterol Cholesterol - chemistry Cholesterol - metabolism Cold Disorders Evolution Human Physiology Humans Ion channels Life Sciences Lipids Low temperature Microenvironments Mutation Neurodegeneration Physiological disorders Physiology Protein Binding Proteins Residues Science education Temperature Transient receptor potential proteins TRPM Cation Channels - chemistry TRPM Cation Channels - genetics TRPM Cation Channels - metabolism Water Water - chemistry Water - metabolism Water conservation
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