An Immune‐Enhancing Injectable Hydrogel Loaded with Esketamine and DDP Promotes Painless Immunochemotherapy to Inhibit Breast Cancer Growth

Chemotherapy is the cornerstone of triple‐negative breast cancer. The poor effectiveness and severe neuropathic pain caused by it have a significant impact on the immune system. Studies confirmed that immune cells in the tumor microenvironment (TME), have critical roles in tumor immune regulation an...

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Veröffentlicht in:	Advanced healthcare materials 2024-11, Vol.13 (29), p.e2401373-n/a
Hauptverfasser:	Yin, Xiali, Ke, Yaohua, Liang, Ying, Zhang, Shuxian, Chen, Ziqi, Yu, Lixia, Jiang, Ming, Liu, Qin, Gu, Xiaoping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Anxiety - complications Anxiety - drug therapy Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - immunology Breast Neoplasms - pathology Breast Neoplasms - psychology CD25 antigen CD4 antigen CD8 antigen Cell Growth Processes - drug effects Cell Line, Tumor Chemotherapy Cisplatin Cisplatin - administration & dosage Cisplatin - pharmacology Cisplatin - therapeutic use Dendritic cells Dendritic Cells - drug effects Dendritic Cells - immunology Depression - complications Depression - drug therapy esketamine Female Foxp3 protein Human Umbilical Vein Endothelial Cells Humans Hydrogels Hydrogels - administration & dosage Hydrogels - adverse effects Immune system Immunity, Innate - drug effects Immunoregulation Immunotherapy - methods injectable hydrogel Ketamine - administration & dosage Ketamine - pharmacology Ketamine - therapeutic use local immune Lymph Nodes - drug effects Lymph Nodes - immunology Lymphocytes Lymphocytes T Mice Mice, Inbred BALB C Neuralgia Pain - immunology Pain - prevention & control Pain - psychology Poloxamer - administration & dosage Poloxamer - adverse effects Poloxamers T-Lymphocytes, Regulatory - drug effects Tumor microenvironment Tumor Microenvironment - drug effects Tumors
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