Atypical sphingosine-1-phosphate metabolites—biological implications of alkyl chain length

Sphingosine-1-phosphate (S1P) is a bioactive lipid signaling molecule with pleiotropic implications by both auto- and paracrine signaling. Signaling occurs by engaging five G protein-coupled receptors (S1P 1-5 ) or intracellular pathways. While the extensively studied S1P with a chain length of 18 c...

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Veröffentlicht in:	Pflügers Archiv 2024-12, Vol.476 (12), p.1833-1843
Hauptverfasser:	Glueck, Melanie, Lucaciu, Alexandra, Subburayalu, Julien, Kestner, Roxane Isabelle, Pfeilschifter, Waltraud, Vutukuri, Rajkumar, Pfeilschifter, Josef
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Blood & organ donations Brain research Carbon Cell Biology Cell survival Enzymes Fatty acids G protein-coupled receptors Hospitals Human Physiology Humans Intracellular signalling Invited Review Kinases Lipids Lymphocytes Lysophospholipids - metabolism Medical research Metabolites Molecular Medicine Neurosciences Paracrine signalling Physiology Receptors Signal Transduction Sphingosine - analogs & derivatives Sphingosine - metabolism Sphingosine 1-phosphate
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