Cytochrome P-450 induction by clofibrate. Purification and properties of a hepatic cytochrome P-450 relatively specific for the 12- and 11-hydroxylation of dodecanoic acid (lauric acid)

Hypolipidaemic drugs induce peroxisomal proliferation in the liver and many induce the formation of the hepatic endoplasmic reticulum in general and the formation of cytochrome P-450 in particular. We have induced the formation of rat liver microsomal cytochrome P-450 by the administration of the hy...

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Veröffentlicht in:	Biochemical journal 1982-04, Vol.203 (1), p.161-168
Hauptverfasser:	Gibson, G G, Orton, T C, Tamburini, P P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzphetamine - metabolism Catalysis clofibrate Clofibrate - pharmacology cytochrome P-450 Cytochrome P-450 Enzyme System - isolation & purification Cytochrome P-450 Enzyme System - metabolism Electrophoresis, Polyacrylamide Gel Endoplasmic Reticulum - enzymology Enzyme Induction - drug effects Kinetics Lauric Acids - metabolism liver Liver - drug effects Liver - enzymology Male Metalloproteins Mixed Function Oxygenases - metabolism Phenobarbital - pharmacology purification Rats Rats, Inbred Strains
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