Harsh parenting, amygdala functional connectivity changes across childhood, and behavioral problems
Harsh parenting in early childhood is related to offspring's adverse behavioral outcomes. Due to the scarcity of longitudinal neuroimaging data, few studies have explored the neurobiological underpinnings of this association, focusing on within-person variability. This study examined the tempor...
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| creator | Koyama, Yuna Tiemeier, Henning Huang, Pei Chan, Shi Yu Sudo, Mioko Kyeong, Yena Meaney, Michael Setoh, Peipei Tan, Ai Peng |
| description | Harsh parenting in early childhood is related to offspring's adverse behavioral outcomes. Due to the scarcity of longitudinal neuroimaging data, few studies have explored the neurobiological underpinnings of this association, focusing on within-person variability. This study examined the temporal associations among harsh parenting, later behavioral problems, and the developmental trajectories of amygdala volume and amygdala resting-state functional connectivity (RSFC) profiles, using longitudinal neuroimaging data.
The study was embedded in the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort. T1-weighted (296 children, 642 scans) and resting-state functional scans (256 children, 509 scans) were collected at ages 4.5, 6, 7.5, and 10.5 years. Amygdala volume and RSFC between the amygdala and six brain regions that have leading roles in emotional regulation were extracted. Harsh parenting at 4.5 years and child behavioral problems at 10.5 years were assessed via parent-report questionnaires. Linear regression and linear mixed models were applied.
Harsh parenting was associated with more severe externalizing problems in girls (
= 0.24, 95% CI 0.08-0.40) but not boys (
= 0.07). In the overall sample, harsh parenting was associated with the developmental trajectories of amygdala-ACC, amygdala-OFC, and amygdala-DLPFC RSFC. In addition, the developmental trajectory of amygdala-ACC RSFC mediated the harsh parenting-externalizing problems association in girls (indirect effect = 0.06, 95% CI 0.01-0.14).
Harsh parenting in early childhood was associated with amygdala neurocircuitry development and behavioral problems. The developmental trajectory of amygdala-ACC RSFC is a potential neural mechanism linking harsh parenting and externalizing problems in girls. |
| doi_str_mv | 10.1017/S003329172400196X |
| format | Article |
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The study was embedded in the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort. T1-weighted (296 children, 642 scans) and resting-state functional scans (256 children, 509 scans) were collected at ages 4.5, 6, 7.5, and 10.5 years. Amygdala volume and RSFC between the amygdala and six brain regions that have leading roles in emotional regulation were extracted. Harsh parenting at 4.5 years and child behavioral problems at 10.5 years were assessed via parent-report questionnaires. Linear regression and linear mixed models were applied.
Harsh parenting was associated with more severe externalizing problems in girls (
= 0.24, 95% CI 0.08-0.40) but not boys (
= 0.07). In the overall sample, harsh parenting was associated with the developmental trajectories of amygdala-ACC, amygdala-OFC, and amygdala-DLPFC RSFC. In addition, the developmental trajectory of amygdala-ACC RSFC mediated the harsh parenting-externalizing problems association in girls (indirect effect = 0.06, 95% CI 0.01-0.14).
Harsh parenting in early childhood was associated with amygdala neurocircuitry development and behavioral problems. The developmental trajectory of amygdala-ACC RSFC is a potential neural mechanism linking harsh parenting and externalizing problems in girls.</description><identifier>ISSN: 0033-2917</identifier><identifier>ISSN: 1469-8978</identifier><identifier>EISSN: 1469-8978</identifier><identifier>DOI: 10.1017/S003329172400196X</identifier><identifier>PMID: 39479759</identifier><language>eng</language><publisher>England: Cambridge University Press</publisher><subject>Amygdala ; Associations ; Behavior problems ; Brain research ; Child development ; Childhood ; Children ; Children & youth ; Developmental delays ; Emotional behavior ; Emotional regulation ; Externalizing problems ; Functional connectivity ; Longitudinal studies ; Magnetic resonance imaging ; Medical imaging ; Mental depression ; Neural networks ; Neuroimaging ; Original ; Parents & parenting ; Regression analysis ; Resting ; Review boards ; Scarcity ; Social development</subject><ispartof>Psychological medicine, 2024-10, Vol.54 (14), p.1-3820</ispartof><rights>Copyright © The Author(s), 2024. Published by Cambridge University Press. This work is licensed under the Creative Commons Attribution – Non-Commercial – Share Alike License This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike licence (http://creativecommons.org/licenses/by-nc-sa/4.0), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the same Creative Commons licence is used to distribute the re-used or adapted article and the original article is properly cited. The written permission of Cambridge University Press must be obtained prior to any commercial use. (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2024 2024 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c310t-f6938d30f8fc0680dd7f8317ae453bab53a6e15f968178dcecaf6402ebe89cc53</cites><orcidid>0000-0001-9091-7477</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,12825,27901,27902,30976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39479759$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koyama, Yuna</creatorcontrib><creatorcontrib>Tiemeier, Henning</creatorcontrib><creatorcontrib>Huang, Pei</creatorcontrib><creatorcontrib>Chan, Shi Yu</creatorcontrib><creatorcontrib>Sudo, Mioko</creatorcontrib><creatorcontrib>Kyeong, Yena</creatorcontrib><creatorcontrib>Meaney, Michael</creatorcontrib><creatorcontrib>Setoh, Peipei</creatorcontrib><creatorcontrib>Tan, Ai Peng</creatorcontrib><title>Harsh parenting, amygdala functional connectivity changes across childhood, and behavioral problems</title><title>Psychological medicine</title><addtitle>Psychol Med</addtitle><description>Harsh parenting in early childhood is related to offspring's adverse behavioral outcomes. Due to the scarcity of longitudinal neuroimaging data, few studies have explored the neurobiological underpinnings of this association, focusing on within-person variability. This study examined the temporal associations among harsh parenting, later behavioral problems, and the developmental trajectories of amygdala volume and amygdala resting-state functional connectivity (RSFC) profiles, using longitudinal neuroimaging data.
The study was embedded in the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort. T1-weighted (296 children, 642 scans) and resting-state functional scans (256 children, 509 scans) were collected at ages 4.5, 6, 7.5, and 10.5 years. Amygdala volume and RSFC between the amygdala and six brain regions that have leading roles in emotional regulation were extracted. Harsh parenting at 4.5 years and child behavioral problems at 10.5 years were assessed via parent-report questionnaires. Linear regression and linear mixed models were applied.
Harsh parenting was associated with more severe externalizing problems in girls (
= 0.24, 95% CI 0.08-0.40) but not boys (
= 0.07). In the overall sample, harsh parenting was associated with the developmental trajectories of amygdala-ACC, amygdala-OFC, and amygdala-DLPFC RSFC. In addition, the developmental trajectory of amygdala-ACC RSFC mediated the harsh parenting-externalizing problems association in girls (indirect effect = 0.06, 95% CI 0.01-0.14).
Harsh parenting in early childhood was associated with amygdala neurocircuitry development and behavioral problems. The developmental trajectory of amygdala-ACC RSFC is a potential neural mechanism linking harsh parenting and externalizing problems in girls.</description><subject>Amygdala</subject><subject>Associations</subject><subject>Behavior problems</subject><subject>Brain research</subject><subject>Child development</subject><subject>Childhood</subject><subject>Children</subject><subject>Children & youth</subject><subject>Developmental delays</subject><subject>Emotional behavior</subject><subject>Emotional regulation</subject><subject>Externalizing problems</subject><subject>Functional connectivity</subject><subject>Longitudinal studies</subject><subject>Magnetic resonance imaging</subject><subject>Medical imaging</subject><subject>Mental depression</subject><subject>Neural networks</subject><subject>Neuroimaging</subject><subject>Original</subject><subject>Parents & parenting</subject><subject>Regression analysis</subject><subject>Resting</subject><subject>Review 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changes across childhood, and behavioral problems</atitle><jtitle>Psychological medicine</jtitle><addtitle>Psychol Med</addtitle><date>2024-10-01</date><risdate>2024</risdate><volume>54</volume><issue>14</issue><spage>1</spage><epage>3820</epage><pages>1-3820</pages><issn>0033-2917</issn><issn>1469-8978</issn><eissn>1469-8978</eissn><abstract>Harsh parenting in early childhood is related to offspring's adverse behavioral outcomes. Due to the scarcity of longitudinal neuroimaging data, few studies have explored the neurobiological underpinnings of this association, focusing on within-person variability. This study examined the temporal associations among harsh parenting, later behavioral problems, and the developmental trajectories of amygdala volume and amygdala resting-state functional connectivity (RSFC) profiles, using longitudinal neuroimaging data.
The study was embedded in the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort. T1-weighted (296 children, 642 scans) and resting-state functional scans (256 children, 509 scans) were collected at ages 4.5, 6, 7.5, and 10.5 years. Amygdala volume and RSFC between the amygdala and six brain regions that have leading roles in emotional regulation were extracted. Harsh parenting at 4.5 years and child behavioral problems at 10.5 years were assessed via parent-report questionnaires. Linear regression and linear mixed models were applied.
Harsh parenting was associated with more severe externalizing problems in girls (
= 0.24, 95% CI 0.08-0.40) but not boys (
= 0.07). In the overall sample, harsh parenting was associated with the developmental trajectories of amygdala-ACC, amygdala-OFC, and amygdala-DLPFC RSFC. In addition, the developmental trajectory of amygdala-ACC RSFC mediated the harsh parenting-externalizing problems association in girls (indirect effect = 0.06, 95% CI 0.01-0.14).
Harsh parenting in early childhood was associated with amygdala neurocircuitry development and behavioral problems. The developmental trajectory of amygdala-ACC RSFC is a potential neural mechanism linking harsh parenting and externalizing problems in girls.</abstract><cop>England</cop><pub>Cambridge University Press</pub><pmid>39479759</pmid><doi>10.1017/S003329172400196X</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-9091-7477</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Amygdala Associations Behavior problems Brain research Child development Childhood Children Children & youth Developmental delays Emotional behavior Emotional regulation Externalizing problems Functional connectivity Longitudinal studies Magnetic resonance imaging Medical imaging Mental depression Neural networks Neuroimaging Original Parents & parenting Regression analysis Resting Review boards Scarcity Social development |
| title | Harsh parenting, amygdala functional connectivity changes across childhood, and behavioral problems |
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