SIAH3 is frequently epigenetically silenced in cancer and regulates mitochondrial metabolism

Of the seven in absentia homologue (SIAH) family, three members have been identified in the human genome. In contrast to the E3 ubiquitin ligase encoding SIAH1 and SIAH2, little is known on the regulation and function of SIAH3 in tumorigenesis. In this study, we reveal that SIAH3 is frequently epige...

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Veröffentlicht in:	International journal of cancer 2025-01, Vol.156 (2), p.353-367
Hauptverfasser:	Deutschmeyer, Verena E, Schlaudraff, Nico A, Walesch, Sara K, Moyer, Janine, Sokol, Anna M, Graumann, Johannes, Meissner, Wolfgang, Schneider, Marc, Muley, Thomas, Helmbold, Peter, Schwinn, Markus, Richter, Antje M, Schmitz, M Lienhard, Dammann, Reinhard H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Cancer Cell death Cell Line, Tumor Cell proliferation Cell Proliferation - genetics Cell survival Epigenesis, Genetic Epigenetics Gene Expression Regulation, Neoplastic Gene Silencing Glycolysis Glycolysis - genetics Head & neck cancer Humans Lung cancer Melanoma Metabolism Mitochondria Mitochondria - genetics Mitochondria - metabolism Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Nuclear Proteins - genetics Nuclear Proteins - metabolism Oxidative metabolism Oxidative Phosphorylation Phosphorylation RESEARCH ARTICLE Tumor suppressor genes Tumorigenesis Ubiquitin-protein ligase Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
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