The P38MAPK Pathway Mediates the Destruction of the Blood–Brain Barrier in Anti-NMDAR Encephalitis Mice

The clinical manifestations of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis may be closely related to the integrity of the blood–brain barrier (BBB). The P38 mitogen-activated protein kinase (P38MAPK) pathway plays a protective role in neurodegenerative diseases. However, whether the P38M...

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Veröffentlicht in:	Neurochemical research 2025-02, Vol.50 (1), p.21, Article 21
Hauptverfasser:	Lao, Dayuan, Gong, Zhuowei, Li, Taiyan, Mo, Xuean, Huang, Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-N-Methyl-D-Aspartate Receptor Encephalitis - metabolism Biochemistry Biomedical and Life Sciences Biomedicine Blood-brain barrier Blood-Brain Barrier - metabolism Cell Biology Damage Down-regulation Encephalitis Female Gelatinase B Glial fibrillary acidic protein Glutamate receptors Imidazoles - pharmacology Immunization Kinases MAP kinase MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Matrix metalloproteinase Matrix metalloproteinases Metalloproteinase Mice N-Methyl-D-aspartic acid receptors Neurochemistry Neurodegenerative diseases Neurology Neuronal-glial interactions Neurosciences p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - metabolism Peptides Proteins Pyridines - pharmacology Structure-function relationships Tumor necrosis factor-TNF Tumor necrosis factor-α
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