Chemical composition and pharmacological aspects of Malaysian stingless bee propolis: An up‑to‑date systematic review

Propolis is a sticky substance produced by stingless bees for construction and defence of their hive. It has notable anti-inflammatory, antioxidant, antibacterial, antifungal, anti-hyperglycemic, and wound healing effects. The present review summarised and examined the phytochemical properties, mode...

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Veröffentlicht in:Biomedical reports 2025-01, Vol.22 (1), p.9, Article 9
Hauptverfasser: Jusril, Nor Atiqah, Mohd, Khamsah Suryati, Abd Mutalib, Nurliana, Mohd Badiazaman, Ainur Awanis
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creator Jusril, Nor Atiqah
Mohd, Khamsah Suryati
Abd Mutalib, Nurliana
Mohd Badiazaman, Ainur Awanis
description Propolis is a sticky substance produced by stingless bees for construction and defence of their hive. It has notable anti-inflammatory, antioxidant, antibacterial, antifungal, anti-hyperglycemic, and wound healing effects. The present review summarised and examined the phytochemical properties, mode of action and current research prospects of Malaysian propolis. A database search using Google Scholar, Web of Science and ScienceDirect generated 780 references; 30 relevant articles were included in the present review, of which 23 were studies and 7 were or animal studies. Propolis demonstrated antioxidant, antibacterial, antifungal, anti-inflammatory and anti-hyperglycemic properties, indicating potential as a wound healing agent. Despite favourable findings, due to the scarcity of studies in the literature, more in-depth research and clinical validation on the synergistic effects, efficacy and optimum dosage of propolis are needed.
doi_str_mv 10.3892/br.2024.1887
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source Spandidos Publications Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central
subjects Antiinfectives and antibacterials
Antimicrobial agents
Antioxidants
Apoptosis
Beehives
Breast cancer
Chemical composition
Chemical compounds
Cytotoxicity
Drug dosages
Fungicides
In vivo methods and tests
Inflammation
Morphology
Pharmaceuticals
Propolis
Reviews
Science
Synergistic effect
Systematic review
Toxicity
Wound healing
title Chemical composition and pharmacological aspects of Malaysian stingless bee propolis: An up‑to‑date systematic review
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